<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Клинические рекомендации Российской гастроэнтерологической ассоциации и Российского общества по изучению печени по диагностике и лечению холестаза</article-title><trans-title-group xml:lang="en"><trans-title>Clinical guidelines of the Russian gastroenterological association and the Russian society on study of the liver on diagnostics and treatment of cholestasis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Широкова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shirokova</surname><given-names>Ye. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маевская</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mayevskaya</surname><given-names>M. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>Ч. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>Ch. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шифрин</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shifrin</surname><given-names>O. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mayev</surname><given-names>I. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трухманов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhmanov</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А. И. Евдокимова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry», Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>01</day><month>05</month><year>2015</year></pub-date><volume>25</volume><issue>2</issue><fpage>41</fpage><lpage>57</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Широкова Е.Н., Маевская М.В., Павлов Ч.С., Шифрин О.С., Маев И.В., Трухманов А.С., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Широкова Е.Н., Маевская М.В., Павлов Ч.С., Шифрин О.С., Маев И.В., Трухманов А.С.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Shirokova Y.N., Mayevskaya M.V., Pavlov C.S., Shifrin O.S., Mayev I.V., Trukhmanov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1001">https://www.gastro-j.ru/jour/article/view/1001</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Авезов С. А., Мансуров Ф. Х. Эффективность совместного применения урсодезоксихолевой кислоты и гептрала в лечении первичного билиарного цирроза. Клин мед 2004; 3:55-8.</mixed-citation><mixed-citation xml:lang="en">Авезов С. А., Мансуров Ф. Х. Эффективность совместного применения урсодезоксихолевой кислоты и гептрала в лечении первичного билиарного цирроза. Клин мед 2004; 3:55-8.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Болезни печени и желчевыводящих путей. Руководство для врачей / Под ред. В. Т. Ивашкина. 2-е изд. М.: Изд. Дом «М-Вести», 2005:536 с.</mixed-citation><mixed-citation xml:lang="en">Болезни печени и желчевыводящих путей. Руководство для врачей / Под ред. В. Т. Ивашкина. 2-е изд. М.: Изд. Дом «М-Вести», 2005:536 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В. Т., Буеверов А. О. Аутоиммунные заболевания печени в практике клинициста. 2-е изд. М.: Изд. Дом «М-Вести», 2011:112 с.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В. Т., Буеверов А. О. Аутоиммунные заболевания печени в практике клинициста. 2-е изд. М.: Изд. Дом «М-Вести», 2011:112 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В. Т., Широкова Е. Н. Холестаз. Руководство для врачей. М.: СИМК, 2012:176 с.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В. Т., Широкова Е. Н. Холестаз. Руководство для врачей. М.: СИМК, 2012:176 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В. Т., Широкова Е. Н., Маевская М. В., Ешану В. С., Павлов Ч. С., Золотаревский В. Б. Клиника и лечение аутоиммунного перекреста — аутоиммунного гепатита и первичного билиарного цирроза. Рос журн гастроэнтерол гепатол колопроктол 2005; 15(5):35-40.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В. Т., Широкова Е. Н., Маевская М. В., Ешану В. С., Павлов Ч. С., Золотаревский В. Б. Клиника и лечение аутоиммунного перекреста — аутоиммунного гепатита и первичного билиарного цирроза. Рос журн гастроэнтерол гепатол колопроктол 2005; 15(5):35-40.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Лейшнер У. Аутоиммунные заболевания печени и перекрестный синдром. М.: Анахарсис, 2005:174 с.</mixed-citation><mixed-citation xml:lang="en">Лейшнер У. Аутоиммунные заболевания печени и перекрестный синдром. М.: Анахарсис, 2005:174 с.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Рациональная фармакотерапия в гепатологии / Под ред. В. Т. Ивашкина, А. О. Буеверова. М.: Литтерра, 2009:296 с.</mixed-citation><mixed-citation xml:lang="en">Рациональная фармакотерапия в гепатологии / Под ред. В. Т. Ивашкина, А. О. Буеверова. М.: Литтерра, 2009:296 с.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Шерлок Ш., Дули Дж. Заболевания печени и желчных путей: Практич. руководство: Пер. с англ. / Под. ред. З. Г. Апросиной, Н. А. Мухина. М.: Гэотар Медицина, 1999:864 с.</mixed-citation><mixed-citation xml:lang="en">Шерлок Ш., Дули Дж. Заболевания печени и желчных путей: Практич. руководство: Пер. с англ. / Под. ред. З. Г. Апросиной, Н. А. Мухина. М.: Гэотар Медицина, 1999:864 с.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Широкова Е. Н. Современные подходы к диагностике и лечению холестаза. Клин персп гастроэнтерол гепатол 2008; 4:33-9.</mixed-citation><mixed-citation xml:lang="en">Широкова Е. Н. Современные подходы к диагностике и лечению холестаза. Клин персп гастроэнтерол гепатол 2008; 4:33-9.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Широкова Е. Н. Молекулярные механизмы холестаза. Рос мед вести 2009; 1:15-22.</mixed-citation><mixed-citation xml:lang="en">Широкова Е. Н. Молекулярные механизмы холестаза. Рос мед вести 2009; 1:15-22.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Широкова Е. Н., Ивашкин К. В., Ивашкин В. Т. Аутоиммунный гепатит: новое в диагностике, патогенезе и лечении. Рос журн гастроэнтерол гепатол колопроктол 2012; 22(5):37-45.</mixed-citation><mixed-citation xml:lang="en">Широкова Е. Н., Ивашкин К. В., Ивашкин В. Т. Аутоиммунный гепатит: новое в диагностике, патогенезе и лечении. Рос журн гастроэнтерол гепатол колопроктол 2012; 22(5):37-45.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Широкова Е. Н., Кузнецова Е. Л., Маевская М. В., Павлов Ч. С., Золотаревский В. Б., Ивашкин В. Т. Эффективность урсодезоксихолевой кислоты в лечении больных холестатической формой алкогольной болезни печени и первичным билиарным циррозом. Рос журн гастроэнтерол гепатол колопроктол 2007; 17(3):52-8.</mixed-citation><mixed-citation xml:lang="en">Широкова Е. Н., Кузнецова Е. Л., Маевская М. В., Павлов Ч. С., Золотаревский В. Б., Ивашкин В. Т. Эффективность урсодезоксихолевой кислоты в лечении больных холестатической формой алкогольной болезни печени и первичным билиарным циррозом. Рос журн гастроэнтерол гепатол колопроктол 2007; 17(3):52-8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez F., Berg P. A., Bianchi F. B., et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999; 31:929.</mixed-citation><mixed-citation xml:lang="en">Alvarez F., Berg P. A., Bianchi F. B., et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999; 31:929.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Baragiotta A., James O. F.W., Craig W., et al. Autoimmune hepatitis: clinical spectrum of disease defined by revised International Autoimmune Hepatitis Group (IAHG) scoring system. J Hepatol 2002; 35(Suppl. 1):261.</mixed-citation><mixed-citation xml:lang="en">Baragiotta A., James O. F.W., Craig W., et al. Autoimmune hepatitis: clinical spectrum of disease defined by revised International Autoimmune Hepatitis Group (IAHG) scoring system. J Hepatol 2002; 35(Suppl. 1):261.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Beuers U. Hepatic overlap syndromes. J Hepatol 2005; 42(Suppl. 1):93-100.</mixed-citation><mixed-citation xml:lang="en">Beuers U. Hepatic overlap syndromes. J Hepatol 2005; 42(Suppl. 1):93-100.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Beuers U. Drug Insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006; 3(6):318-28.</mixed-citation><mixed-citation xml:lang="en">Beuers U. Drug Insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006; 3(6):318-28.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Binder T., Salaj P., Zima T., Vitek L. Randomized prospective comparative study of ursodeoxycholic acid and Ы-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinatal Med 2006; 34:383-91.</mixed-citation><mixed-citation xml:lang="en">Binder T., Salaj P., Zima T., Vitek L. Randomized prospective comparative study of ursodeoxycholic acid and Ы-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinatal Med 2006; 34:383-91.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chan C. W., Gunsar F., Feudjo M., et al. Long-term ursodeoxycholic acid therapy for primary biliary cirrhosis: a follow-up to 12 years. Aliment Pharmacol Ther 2005; 21(3):217-26.</mixed-citation><mixed-citation xml:lang="en">Chan C. W., Gunsar F., Feudjo M., et al. Long-term ursodeoxycholic acid therapy for primary biliary cirrhosis: a follow-up to 12 years. Aliment Pharmacol Ther 2005; 21(3):217-26.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Chazouilleres O., Wendum D., Serfaty L., et al. Long term outcome and response to therapy of primary biliary cirrhosis — autoimmune hepatitis overlap syndrome. J Hepatol 2006; 44(2):400-6.</mixed-citation><mixed-citation xml:lang="en">Chazouilleres O., Wendum D., Serfaty L., et al. Long term outcome and response to therapy of primary biliary cirrhosis — autoimmune hepatitis overlap syndrome. J Hepatol 2006; 44(2):400-6.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Combes B., Luketic V. A., Peters M. G. Prolonged follow-up of patients in the U.S. multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis. Am J Gastroenterol 2004; 99(2):264-8.</mixed-citation><mixed-citation xml:lang="en">Combes B., Luketic V. A., Peters M. G. Prolonged follow-up of patients in the U.S. multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis. Am J Gastroenterol 2004; 99(2):264-8.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Corpechot C., Carrat F., Bonnand A. M., et al. The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis. Hepatology 2000; 32(6):1196-9.</mixed-citation><mixed-citation xml:lang="en">Corpechot C., Carrat F., Bonnand A. M., et al. The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis. Hepatology 2000; 32(6):1196-9.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Corpechot C., Carrat F., Bahr A., et al. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005; 128(2):297-303.</mixed-citation><mixed-citation xml:lang="en">Corpechot C., Carrat F., Bahr A., et al. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005; 128(2):297-303.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Czaja A. J. Autoimmune hepatitis with incidental histologic features of bile duct injury. Hepatology 2001; 34(10):659-65.</mixed-citation><mixed-citation xml:lang="en">Czaja A. J. Autoimmune hepatitis with incidental histologic features of bile duct injury. Hepatology 2001; 34(10):659-65.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Czaja A. J. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: A foray across diagnostic boundaries. J Hepatol 2006; 44:251-2.</mixed-citation><mixed-citation xml:lang="en">Czaja A. J. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: A foray across diagnostic boundaries. J Hepatol 2006; 44:251-2.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Davit-Spraul A., Gonzales E., Baussan C., Jacquemin E. The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. Semin Liver Dis 2010; 30:134-46.</mixed-citation><mixed-citation xml:lang="en">Davit-Spraul A., Gonzales E., Baussan C., Jacquemin E. The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. Semin Liver Dis 2010; 30:134-46.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dickson E. R., Grambsch P. M., Fleming T. R., et al. Prognosis in primary biliary cirrhosis: model for decision making. Hepatology 1989; 10(1):1-7.</mixed-citation><mixed-citation xml:lang="en">Dickson E. R., Grambsch P. M., Fleming T. R., et al. Prognosis in primary biliary cirrhosis: model for decision making. Hepatology 1989; 10(1):1-7.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Durazzo M., Premoli A., Fagoonee S., Pelicano R. Overlap syndromes of autoimmune hepatitis: what as know so far. Dig Dis Sci 2003; 48(3):423-30.</mixed-citation><mixed-citation xml:lang="en">Durazzo M., Premoli A., Fagoonee S., Pelicano R. Overlap syndromes of autoimmune hepatitis: what as know so far. Dig Dis Sci 2003; 48(3):423-30.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Eriksson L. S., Olsson R., Glauman H., et al. Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis: a Swedish multicenter, double-blind, randomized controlled study. Scand J Gastroenterol 1997; 32(2):179-86.</mixed-citation><mixed-citation xml:lang="en">Eriksson L. S., Olsson R., Glauman H., et al. Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis: a Swedish multicenter, double-blind, randomized controlled study. Scand J Gastroenterol 1997; 32(2):179-86.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Gluud C., Christensen E. Ursodeoxycholic acid for primary biliary cirrhosis. The Cochrane database of systematic reviews 2001. Issue 4. Art.No.: CD000551. DOI:10.1002/14651858.CD000551.</mixed-citation><mixed-citation xml:lang="en">Gluud C., Christensen E. Ursodeoxycholic acid for primary biliary cirrhosis. The Cochrane database of systematic reviews 2001. Issue 4. Art.No.: CD000551. DOI:10.1002/14651858.CD000551.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gong Y., Huang Z., Christensen E., Gluud C. Ursodeoxycholic acid for patients with primary biliary cirrhosis: an updated systematic review and meta-analysis of randomized clinical trials using bayesian approach as sensitivity analyses. Am J Gastroenterol 2007; 102:1799-807.</mixed-citation><mixed-citation xml:lang="en">Gong Y., Huang Z., Christensen E., Gluud C. Ursodeoxycholic acid for patients with primary biliary cirrhosis: an updated systematic review and meta-analysis of randomized clinical trials using bayesian approach as sensitivity analyses. Am J Gastroenterol 2007; 102:1799-807.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Goulis J., Leandro G., Burroughs A. K. Randomised controlled trials of ursodeoxycholic acid therapy for primary biliary cirrhosis: a meta-analysis. Lancet 1999; 354(9184):1053-60.</mixed-citation><mixed-citation xml:lang="en">Goulis J., Leandro G., Burroughs A. K. Randomised controlled trials of ursodeoxycholic acid therapy for primary biliary cirrhosis: a meta-analysis. Lancet 1999; 354(9184):1053-60.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gunsar F., Akara U. S., Ersoz G., et al. Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Hepato-Gastroenterol 2002; 49:1195-2000.</mixed-citation><mixed-citation xml:lang="en">Gunsar F., Akara U. S., Ersoz G., et al. Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Hepato-Gastroenterol 2002; 49:1195-2000.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Heathcote E. J. Overlap of autoimmune hepatitis and primary biliary cirrhosis: an evalution of a modified scoring system. Am J Gastroenterol 2002; 97(5):1090-2.</mixed-citation><mixed-citation xml:lang="en">Heathcote E. J. Overlap of autoimmune hepatitis and primary biliary cirrhosis: an evalution of a modified scoring system. Am J Gastroenterol 2002; 97(5):1090-2.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Heathcote J. Diagnosis of primary biliary liver diseases, overlap syndromes and changing diagnosis. In: Dienes H.-P., Leuschner U., Lohse A. W., Manns M. P., eds. Autoimmune liver diseases. Dordrecht: Springer; 2005:171-9.</mixed-citation><mixed-citation xml:lang="en">Heathcote J. Diagnosis of primary biliary liver diseases, overlap syndromes and changing diagnosis. In: Dienes H.-P., Leuschner U., Lohse A. W., Manns M. P., eds. Autoimmune liver diseases. Dordrecht: Springer; 2005:171-9.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jones D. E. Pathogenesis of primary biliary cirrhosis. Clin Liver Dis 2008; 12 (2):305-21.</mixed-citation><mixed-citation xml:lang="en">Jones D. E. Pathogenesis of primary biliary cirrhosis. Clin Liver Dis 2008; 12 (2):305-21.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan M. M., Gershwin M. E. Primary biliary cirrhosis. N Engl J Med 2005; 353(12):1261-73.</mixed-citation><mixed-citation xml:lang="en">Kaplan M. M., Gershwin M. E. Primary biliary cirrhosis. N Engl J Med 2005; 353(12):1261-73.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Keitel V., Burdelski M., Warskulat U., et al. Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology 2005; 42(4):977-8.</mixed-citation><mixed-citation xml:lang="en">Keitel V., Burdelski M., Warskulat U., et al. Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology 2005; 42(4):977-8.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Kis J., Csepregi A., Strassburg C. P., et al. Antimitochondrial antibodies against dihydrolipoamide acyltransferases (PDC-E2 and BCKADCE2) in immunofluorescent AMA-negative rheumatoid arthritis sera. J Hepatol 2002; 36(Suppl. 1):153.</mixed-citation><mixed-citation xml:lang="en">Kis J., Csepregi A., Strassburg C. P., et al. Antimitochondrial antibodies against dihydrolipoamide acyltransferases (PDC-E2 and BCKADCE2) in immunofluorescent AMA-negative rheumatoid arthritis sera. J Hepatol 2002; 36(Suppl. 1):153.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Konstantinos N. L., Gores G. J., Lindor K. D. Ursodeoxycholic acid «mechanims of action and clinical use in hepatobiliary disorders». J Hepatol 2001; 35:134-46.</mixed-citation><mixed-citation xml:lang="en">Konstantinos N. L., Gores G. J., Lindor K. D. Ursodeoxycholic acid «mechanims of action and clinical use in hepatobiliary disorders». J Hepatol 2001; 35:134-46.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kosters A., Karpen S. The role of inflammation in cholestasis: clinical and basic aspects. Semin Liver Dis 2010; 30:186-94.</mixed-citation><mixed-citation xml:lang="en">Kosters A., Karpen S. The role of inflammation in cholestasis: clinical and basic aspects. Semin Liver Dis 2010; 30:186-94.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kuntz E., Kuntz H. Hepatology principles and practice, 2nd ed. Springer Verlag Berlin, Heiderberg, 2006:906 p.</mixed-citation><mixed-citation xml:lang="en">Kuntz E., Kuntz H. Hepatology principles and practice, 2nd ed. Springer Verlag Berlin, Heiderberg, 2006:906 p.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Lam P., Soroka C., Boyer J. The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease. Semin Liver Dis 2010; 30:125-33.</mixed-citation><mixed-citation xml:lang="en">Lam P., Soroka C., Boyer J. The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease. Semin Liver Dis 2010; 30:125-33.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Lazaridis K. N., Gores G. J., Lindor K. D. Ursodeoxycholic acid «mechanisms of action and clinical use in hepatobiliary disorders». J Hepatol 2001; 35:134-46.</mixed-citation><mixed-citation xml:lang="en">Lazaridis K. N., Gores G. J., Lindor K. D. Ursodeoxycholic acid «mechanisms of action and clinical use in hepatobiliary disorders». J Hepatol 2001; 35:134-46.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Leuschner U., Manns M. P., Eisebitt R. Ursodeoxycholic acid in the therapy for primary biliary cirrhosis: effects on progression and prognosis. Z Gastroenterol 2005; 43:1051-9.</mixed-citation><mixed-citation xml:lang="en">Leuschner U., Manns M. P., Eisebitt R. Ursodeoxycholic acid in the therapy for primary biliary cirrhosis: effects on progression and prognosis. Z Gastroenterol 2005; 43:1051-9.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Lindor K. D., Poupon R., Poupon R., et al. Ursodeoxycholic acid for primary biliary cirrhosis. Lancet 2000; 355(9204):657-8.</mixed-citation><mixed-citation xml:lang="en">Lindor K. D., Poupon R., Poupon R., et al. Ursodeoxycholic acid for primary biliary cirrhosis. Lancet 2000; 355(9204):657-8.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Lindor K. D., Talwalkar J. A., eds. Cholestatic liver disease. New Jersey: Humana Press, 2008:188 p.</mixed-citation><mixed-citation xml:lang="en">Lindor K. D., Talwalkar J. A., eds. Cholestatic liver disease. New Jersey: Humana Press, 2008:188 p.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Marschall H. U., Wagner M., Zollner G., Fickert P., et al. Rifampicin and ursodeoxycholic acid in cholestatic liver disease. Gastroenterology 2005; 129(2):476-85.</mixed-citation><mixed-citation xml:lang="en">Marschall H. U., Wagner M., Zollner G., Fickert P., et al. Rifampicin and ursodeoxycholic acid in cholestatic liver disease. Gastroenterology 2005; 129(2):476-85.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Noe J., Kullak-Ublick G.A., Jochum W., Stieger B., et al. Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. J Hepatol 2005; 43(3):536-43.</mixed-citation><mixed-citation xml:lang="en">Noe J., Kullak-Ublick G.A., Jochum W., Stieger B., et al. Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. J Hepatol 2005; 43(3):536-43.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Papatheodoridis G. V., Deutsch M., Hadziyannis E., et al. Ursodeoxycholic acid for primary biliary cirrhosis: final results of a 12-year prspective rendomised controlled trial. J Hepatol 2000; 32(Suppl. 2):40A.</mixed-citation><mixed-citation xml:lang="en">Papatheodoridis G. V., Deutsch M., Hadziyannis E., et al. Ursodeoxycholic acid for primary biliary cirrhosis: final results of a 12-year prspective rendomised controlled trial. J Hepatol 2000; 32(Suppl. 2):40A.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Pares A., Caballeria L., Rodes J., et al. Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: results of a double-blind controlled multicentric trial. UDCA-Cooperative Group from the Spanish Association for the Study of the Liver. J Hepatol 2000; 32:561-6.</mixed-citation><mixed-citation xml:lang="en">Pares A., Caballeria L., Rodes J., et al. Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: results of a double-blind controlled multicentric trial. UDCA-Cooperative Group from the Spanish Association for the Study of the Liver. J Hepatol 2000; 32:561-6.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Pares A., Caballeria L., Rodes J. Excellent long-term survival in patients with in primary biliary cirrhosis and biochemical response to ursodeoxycholic acid. Gastroenterology 2006; 130:715-20.</mixed-citation><mixed-citation xml:lang="en">Pares A., Caballeria L., Rodes J. Excellent long-term survival in patients with in primary biliary cirrhosis and biochemical response to ursodeoxycholic acid. Gastroenterology 2006; 130:715-20.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Paulusma C., Ronald P., Elferink O., Jansen P. Progressive familial intrahepatic cholestasis type 1. Semin Liver Dis 2010; 30:117-24.</mixed-citation><mixed-citation xml:lang="en">Paulusma C., Ronald P., Elferink O., Jansen P. Progressive familial intrahepatic cholestasis type 1. Semin Liver Dis 2010; 30:117-24.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Paumgartner G., Pusl T. Medical treatment of cholestatic liver disease. Clin Liver Dis 2008; 12:53-81.</mixed-citation><mixed-citation xml:lang="en">Paumgartner G., Pusl T. Medical treatment of cholestatic liver disease. Clin Liver Dis 2008; 12:53-81.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Poupon R. E. Management of primary biliary cirrhosis resistant to UDCA therapy. J Hepatol 2000; 32 (Suppl. 2):19-20.</mixed-citation><mixed-citation xml:lang="en">Poupon R. E. Management of primary biliary cirrhosis resistant to UDCA therapy. J Hepatol 2000; 32 (Suppl. 2):19-20.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Poupon R. E., Bonnard A. M., Chretien Y., et al. Tenyear survival in ursodeoxycholic acid treated patients with primary biliary cirrhosis. J Hepatol 1999; 29:1668-71.</mixed-citation><mixed-citation xml:lang="en">Poupon R. E., Bonnard A. M., Chretien Y., et al. Tenyear survival in ursodeoxycholic acid treated patients with primary biliary cirrhosis. J Hepatol 1999; 29:1668-71.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Poupon R. E., Chazouilleres O., Poupon R. Chronic сholestatic diseases. J. Hepatol 2000; 32 (Suppl 1):129-40.</mixed-citation><mixed-citation xml:lang="en">Poupon R. E., Chazouilleres O., Poupon R. Chronic сholestatic diseases. J. Hepatol 2000; 32 (Suppl 1):129-40.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Poupon R.E, Lindor K. D., Pares A. M., et al. Combined analysis of the effect of treatmet with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis. J Hepatol 2003; 39(1):12-6.</mixed-citation><mixed-citation xml:lang="en">Poupon R.E, Lindor K. D., Pares A. M., et al. Combined analysis of the effect of treatmet with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis. J Hepatol 2003; 39(1):12-6.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Roda E., Azzaroli F., Nigro G., Piazza F., Jaboli F., Ferrara F., et al. Improved liver tests and greater biliary enrichment with high dose ursodeoxycholic acid in early stage primary biliary cirrhosis. Dig Liver Dis 2002; 34:523-7.</mixed-citation><mixed-citation xml:lang="en">Roda E., Azzaroli F., Nigro G., Piazza F., Jaboli F., Ferrara F., et al. Improved liver tests and greater biliary enrichment with high dose ursodeoxycholic acid in early stage primary biliary cirrhosis. Dig Liver Dis 2002; 34:523-7.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Roncaglia N., et al. A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis. BJOG 2004; 111(1):17-21.</mixed-citation><mixed-citation xml:lang="en">Roncaglia N., et al. A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis. BJOG 2004; 111(1):17-21.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Selmi C., Zuin M., Bowlus C. L., Gershwin M. E. Antimitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis 2008; 12:173-87.</mixed-citation><mixed-citation xml:lang="en">Selmi C., Zuin M., Bowlus C. L., Gershwin M. E. Antimitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis 2008; 12:173-87.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Silveira M. G., Talwalkar J. A., Angulo P., et al. Overlap of autoimmune hepatitis and primary biliary cirrhosis: long term outcomes. Am J Gastroenterol 2007; 102(6):1244-50.</mixed-citation><mixed-citation xml:lang="en">Silveira M. G., Talwalkar J. A., Angulo P., et al. Overlap of autoimmune hepatitis and primary biliary cirrhosis: long term outcomes. Am J Gastroenterol 2007; 102(6):1244-50.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki H., Sugiyama Y. Transport of drugs across the hepatic sinusoidal membrane: Sinusoidal drug influx and efflux in the liver. Semin Liver Dis 2000; 20:251-63.</mixed-citation><mixed-citation xml:lang="en">Suzuki H., Sugiyama Y. Transport of drugs across the hepatic sinusoidal membrane: Sinusoidal drug influx and efflux in the liver. Semin Liver Dis 2000; 20:251-63.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Talwalkar J. A., Keach J. C., Angulo P., Lindor K. D. Overlap of autoimmune hepatitis and primary biliary cirrhosis: an evalution of a modified scoring system. Am J Gastroenterol 2001; 97(5):1191-7.</mixed-citation><mixed-citation xml:lang="en">Talwalkar J. A., Keach J. C., Angulo P., Lindor K. D. Overlap of autoimmune hepatitis and primary biliary cirrhosis: an evalution of a modified scoring system. Am J Gastroenterol 2001; 97(5):1191-7.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Ter Borg P. C., Schalm S. W., Hansen B. E., et al. Prognosis of ursodeoxycholic acid-treated patients with primary biliary cirrhosis: results of a 10-yr cohort study involving 297 patients. Am J Gastroenterol 2006; 101(9):2044-50.</mixed-citation><mixed-citation xml:lang="en">Ter Borg P. C., Schalm S. W., Hansen B. E., et al. Prognosis of ursodeoxycholic acid-treated patients with primary biliary cirrhosis: results of a 10-yr cohort study involving 297 patients. Am J Gastroenterol 2006; 101(9):2044-50.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Trauner M., Wagner M., Fickert P., Zollner G. Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J Clin Gastroenterol 2005; 39(4):111-24.</mixed-citation><mixed-citation xml:lang="en">Trauner M., Wagner M., Fickert P., Zollner G. Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J Clin Gastroenterol 2005; 39(4):111-24.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Vergany D., Mieli-Vergani G. Autoimmune hepatitis and PSC connection. Clin Liver Dis 2008; 12:187-203.</mixed-citation><mixed-citation xml:lang="en">Vergany D., Mieli-Vergani G. Autoimmune hepatitis and PSC connection. Clin Liver Dis 2008; 12:187-203.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Vierling J. M. Future treatment options in PBC. Semin Liver Dis 2005; 25(3):347-63.</mixed-citation><mixed-citation xml:lang="en">Vierling J. M. Future treatment options in PBC. Semin Liver Dis 2005; 25(3):347-63.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Zollner G., Trauner M. Mechanisms of cholestasis. Clin Liver Dis 2008; 12(1):1-26.</mixed-citation><mixed-citation xml:lang="en">Zollner G., Trauner M. Mechanisms of cholestasis. Clin Liver Dis 2008; 12(1):1-26.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
