gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2016-6-106-111gastro-j-101Research ArticleНОВОСТИ КОЛОПРОКТОЛОГИИNEWS OF COLOPROCTOLOGYНеинвазивные маркёры активности воспалительных заболеваний кишечникаNoninvasive markers of inflammatory bowel disease activityНикитинАнатолий ВладимировичNikitinA. V.noemail@neicon.ruВасильеваЛюдмила ВалентиновнаVasilyevaL. V.noemail@neicon.ruМатюхинАнатолий АндреевичMatiukhinAnatoly A.matiuhin-doc@yandex.ruГБОУ ВПО «Воронежская государственная медицинская академия им. Н. Н. Бурденко»; Воронежская областная клиническая больница № 1РоссияState educational state-funded institution of higher professional education «Burdenko Voronezh state medical academy»; Voronezh regional hospital No. 1Russian Federation201612082018266106111Copyright © Никитин А.В., Васильева Л.В., Матюхин А.А., 20182018Никитин А.В., Васильева Л.В., Матюхин А.А.Nikitin A.V., Vasilyeva L.V., Matiukhin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/101

Цель исследования. Изучить особенности неинвазивных маркёров активности воспалительных заболеваний кишечника (ВЗК) и оценить корреляцию между различными методами исследования для оценки клинико-эндоскопической активности язвенного колита (ЯК) и болезни Крона (БК). Материал и методы. В исследование было включено 67 человек с ЯК и БК, у которых определялась клиническая и эндоскопическая активность заболевания с гистологическим исследованием биоптатов. Проводилось исследование цитокинов крови - ИЛ-4, ИЛ-8, фактора некроза опухоли α (ФНО-α) и кальцийсвязывающего белка кала (кальпротектина). Результаты. Концентрация кальпротектина и ФНО-α значительно выше у пациентов с высокой активностью заболевания и протяженностью воспалительного процесса. Коэффициент корреляции Спирмена между эндоскопическими параметрами и показателями фекального кальпротектина (0,82) выше у пациентов с ЯК, чем между эндоскопическими параметрами и ФНО-α (0,78) у пациентов с БК. Выводы. При выборе тактики обследования и лечения следует учитывать неинвазивные маркёры активности воспалительного процесса и осуществлять диагностический поиск без применения дорогостоящих инвазивных процедур.

Aim of investigation. To study noninvasive activity markers of inflammatory bowel diseases (IBD) and to estimate correlation between various diagnostic methods for an assessment of clinical and endoscopical activity of ulcerative colitis (UC) and Crohn's disease (CD). Material and methods. Original study included 67 patients with UC and CD in whom clinical and endoscopic activity of the disease with assessed by histological investigation of biopsy specimens. Blood serum cytokines: IL-4, IL-8, tumor necrosis factor α (TNF-α) and fecal calcium binding protein (calprotectin) were assessed. Results. Fecal calprotectin and TNF-α levels were much higher in patients with high disease activity and extent of inflammatory process. Spearman correlation coefficient between endoscopic features and fecal calprotectin (0,82) was higher in the UC patients, than between endoscopic parameters and TNF-α (0,78) in CD patients. Conclusions. Noninvasive inflammatory activity markers should be taken into account and decision-making on diagnostic and treatment strategy, as well as to decrease expensive and invasive diagnostic procedures.

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The authors declare that there are no conflicts of interest present.