gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2026-36-2-104-112gastro-j-1025Research ArticleНАЦИОНАЛЬНАЯ ШКОЛА ГАСТРОЭНТЕРОЛОГИИ, ГЕПАТОЛОГИИNATIONAL COLLEGE OF GASTROENTEROLOGY, HEPATOLOGYРоль инфекции Helicobacter pylori в развитии железодефицитной и В12-дефицитной анемииThe Role of Helicobacter pylori Infection in Iron Deficiency and B12 Deficiency Anemiahttps://orcid.org/0000-0002-1395-9566ШептулинА. А.SheptulinA. A.

Шептулин Аркадий Александрович — доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии Института клинической медицины им. Н.В. Склифосовского

119991, г. Москва, ул. Погодинская, 1, стр. 1.

Arkadiy A. Sheptulin — Dr. Sci. (Med.), Professor of the De- partment of Internal Diseases Propedeutics, Gastroenterology and Hepatology, N.V. Sklyfosovsky Institute of Clinical Medicine

119991, Moscow, Pogodinskaya str., 1, build. 1.

arkalshep@gmail.comhttps://orcid.org/0000-0002-5116-2144КардашеваС. С.KardashevaS. S.

Кардашева Светлана Станиславовна — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии Института клинической медицины им. Н.В. Склифосовского

119991, г. Москва, ул. Погодинская, 1, стр. 1.

Svetlana S. Kardasheva — Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases Propedeutics, Gastroenterology and Hepatology, N.V. Sklyfosovsky Institute of Clinical Medicine

119991, Moscow, Pogodinskaya str., 1, build. 1.

svetlanakardasheva@gmail.comhttps://orcid.org/0000-0002-6154-8163КурбатоваА. А.KurbatovaA. A.

Курбатова Анастасия Александровна — кандидат медицинских наук, ассистент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии Института клинической медицины им. Н.В. Склифосовского

119991, г. Москва, ул. Погодинская, 1, стр. 1.

Anastasia A. Kurbatova — Cand. Sci. (Med.), Teaching Assistant of the Department of Internal Diseases Propedeutics, Gastroenterology and Hepatology, N.V. Sklyfosovsky Institute of Clinical Medicine

119991, Moscow, Pogodinskaya str., 1, build. 1.

maksnastia@mail.ruhttps://orcid.org/0009-0009-5912-647XБенуниН. А.BenuniN. A.

Бенуни Нона Артемовна — студентка

119991, г. Москва, ул. Трубецкая, 8, стр. 2.

Nona A. Benuni — Student

119991, Moscow, Trubetskaya str., 8, build. 2.

nona.benuni@rambler.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202621052026362104112Copyright © Шептулин А.А., Кардашева С.С., Курбатова А.А., Бенуни Н.А., 20262026Шептулин А.А., Кардашева С.С., Курбатова А.А., Бенуни Н.А.Sheptulin A.A., Kardasheva S.S., Kurbatova A.A., Benuni N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1025Цель

Цель: провести анализ современных данных литературы, касающихся возможной связи инфекции Helicobacter pylori (H. pylori) c развитием железодефицитной и В12-дефицитной анемии.

Основные положения

Основные положения. В опубликованных работах показано, что во многих случаях (особенно в педиатрической практике) железодефицитная анемия с неустановленной причиной может быть обусловлена наличием инфекции H. pylori, которая с помощью различных механизмов может приводить к нарушению всасывания железа. Эрадикация этой инфекции способствует восстановлению нормальных показателей красной крови. Кроме этого, у больных, инфицированных H. pylori, отмечается более низкий уровень витамина В12 в крови по сравнению с неинфицированными лицами. Механизмы, способствующие нарушению всасывания витамина В12 у пациентов с инфекцией H. pylori, могут быть связаны с прогрессированием мультифокального атрофического гастрита, а также с выработкой антител к париетальным клеткам и внутреннему фактору Касла. Рекомендации многих национальных гастроэнтерологических обществ и согласительных совещаний считают целесообразным проведение у пациентов, имеющих железодефицитную или В12-дефицитную анемию с неустановленной причиной, тестирования на наличие инфекции H. pylori c последующей эрадикацией.

Заключение

Заключение. Существует положительная связь между инфекцией H. pylori и возникновением железодефицитной анемии с неустановленной причиной. Проблема связи между инфекцией H. pylori и В12-дефицитной анемией изучена недостаточно и требует дальнейших исследований.

Aim

Aim: to review the current literature on the potential link between Helicobacter pylori (H. pylori) infection and iron deficiency and vitamin B12 deficiency anemia.

Key points

Key points. Published studies have shown that iron deficiency anemia of unknown cause may be due to H. pylori infection, especially in pediatric practice. This infection can lead to impaired iron absorption through various mechanisms. Eradicating H. pylori infection can contribute to restoring normal red blood cell parameters. Additionally, patients infected with H. pylori have lower blood levels of vitamin B12 compared to uninfected individuals. The mechanisms contributing to impaired vitamin B12 absorption in patients with H. pylori infection may be associated with the progression of multifocal atrophic gastritis, as well as the production of antibodies against parietal cells and intrinsic factor. Many national gastroenterology societies and consensus meetings recommend testing for H. pylori infection patients with iron deficiency anemia or B12 deficiency anemia of unknown origin and, if positive, eradicating it.

Conclusion

Conclusion. There is a positive association between H. pylori infection and the development of unexplained iron deficiency anemia. The relationship between H. pylori infection and vitamin B12 deficiency anemia has not been sufficiently studied and requires further research.

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The authors declare that there are no conflicts of interest present.