gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1040Research ArticleНОВОСТИ КОЛОПРОКТОЛОГИИNEWS OF COLOPROCTOLOGYФармакогенетические маркёры терапии колоректального рака. Новые подходы для оценки эффективности цитостатических препаратовPharmacogenetic markers of colorectal cancer treatment. New approaches for cytostatic drugs efficacy estimationЗахаржевскаяН. Б.ZakharzhevskayaN. B.КулеминН. А.KuleminN. A.БабиковаЕ. А.BabikovaYe. A.ХомяковаЕ. Б.KhomyakovaYe. B.ГенерозовЭ. В.GenerozovE. V.

Генерозов Эдуард Викторович — доцент, кандидат биологических наук, заведующий лабораторией молекулярной генетики человека

119435, Москва, ул. Малая Пироговская, д.1а

Generozov Edward V. — lecturer, cand. biol. sci. head of the laboratory of molecular human genetics

119435, Moscow, Malaya Pirogovskaya str., 1. 

generozov@gmail.comФГБУ «Федеральный научно-клинический центр физико-химической медицины Федерального медико-биологического агентства»РоссияFederal research and clinical center of physical-chemical medicine, Federal medical biological agencyRussian Federation2015301220152566776Copyright © Захаржевская Н.Б., Кулемин Н.А., Бабикова Е.А., Хомякова Е.Б., Генерозов Э.В., 20152015Захаржевская Н.Б., Кулемин Н.А., Бабикова Е.А., Хомякова Е.Б., Генерозов Э.В.Zakharzhevskaya N.B., Kulemin N.A., Babikova Y.A., Khomyakova Y.B., Generozov E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1040

Цель обзора. Проанализировать и представить данные зарубежных фармакогенетических исследований, посвященных оптимизации лекарственной терапии колоректального рака (КРР), в частности акцентированных на применении препаратов общего цитостатического действия — производных 5-фторурацила, иринотекана, препаратов платины.

Основные положения. В структуре онкозаболеваемости во всем мире КРР занимает традиционно ведущие позиции. При этом успех химиотерапии КРР во многом зависит от индивидуальных генетических особенностей пациента, влияющих как на эффективность лекарственного воздействия, так и на степень проявления побочных эффектов. Если для современных препаратов таргетной терапии, таких как цетуксимаб, эффективность и необходимость фармакогенетического обследования является уже доказанной, то в отношении широко используемых препаратов общего цитостатического действия говорится неоправданно мало.В настоящем обзоре систематизированы и обобщены сведения по наиболее информативным генетическим маркёрам, анализ которых может быть использован для оптимизации лечения пациентов с КРР при применении многокомпонентных режимов химиотерапии, таких как FOLFIRI и FOLFOX.

The aim of review. To analyze and present data of the foreign pharmacogenetic studies devoted to improvement of pharmacological therapy of colorectal cancer (CRC), in particular those, focused on the drugs with general cytostatic action: 5-fluorouracil derivatives, irinotecan and platinum agents.Summary. In the oncological diseases frequency spectrum CRC traditionally occupies the leading positions all over the world. The success of CRC chemotherapy depends significantly on the individual genetic features of the patient influencing both efficacy of pharmacological effects, and degree of side effects severity. If efficacy and necessity of pharmacogenetic investigation for such drugs of targeted therapy, as cetuximab, is already proven for the present time, it is still underestimated for the widely applied drugs of general cytostatic action. This review presents systematic and generalized data on the most informative genetic markers which analysis can be used for optimization of treatment of CRC patients at multicomponent modes of chemotherapy, such as FOLFIRI and FOLFOX.

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The authors declare that there are no conflicts of interest present.