gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1068Research ArticleГЕПАТОЛОГИЯHEPATOLOGYЭффективность терапии и жизненный прогноз при аутоиммунных заболеваниях печениTreatment response rate and life prognosis at autoimmune liver diseasesИвашкинК. В.IvashkinK. V.

Ивашкин Константин Владимирович – кандидат медицинских наук, ассистент кафедры пропедевтики внутренних болезней лечебного факультета 

119991, Москва, ул. Погодинская, д. 1, стр. 1

Ivashkin Konstantin V. — MD, assistant-professor, chair of internal diseases propedeutics

119991, Moscow, Pogodinskaya street, 1, bld 1

2135833@mail.ruШироковаЕ. Н.ShirokovaYe. N.ИвашкинВ. Т.IvashkinV. T.ГБОУ ВПО «Первый Московский государственный медицинский университет им И.М. Сеченова» Минздрава РоссииРоссияState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationRussian Federation2015301020152554656Copyright © Ивашкин К.В., Широкова Е.Н., Ивашкин В.Т., 20152015Ивашкин К.В., Широкова Е.Н., Ивашкин В.Т.Ivashkin K.V., Shirokova Y.N., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1068

Цель обзора. Провести сравнительный анализ современных исследований и охарактеризовать актуальные схемы лечения, а также сформулировать прогноз и особенности ответа на терапию у пациентов с различными аутоиммунными заболеваниями печени.Основные положения. Диагностика и лечение — наиболее сложные и не до конца изученные аспекты аутоиммунных заболеваний печени. Благодаря крупным исследованиям клиницистами выработано некоторое понимание подходов к терапии таких больных. В статье описаны современные лечебные схемы и новые препараты, на которые возлагается большая надежда, а также сложности и альтернативные варианты терапии аутоиммунных заболеваний печени.Заключение. Правильная и длительная (12–24 месяца) терапия аутоиммунных заболеваний в большинстве случаев позволяет достичь стойкого ответа и в несколько раз превосходит по эффективности короткие курсы (6–12 месяцев).

The aim of review

The aim of review. To carry out comparative analysis of modern studies, to characterize actual modes of treatment and to define prognosis and features of treatment response at various autoimmune liver diseases.

Key points

Key points. Diagnostics and treatment are the most complex and insufficiently investigated aspects of autoimmune liver diseases. Due to large studies, clinicians gain some understanding of approaches to therapy of these patients. Article presents up-to-date management algorithms and new promising agents, demonstrates complexities and alternative variants of treatment of autoimmune liver diseases.

Conclusion

Conclusion. Appropriate and long-term (for 12–24 months) therapy of autoimmune diseases in most cases allows to achieve sustained response and in several folds surpasses efficacy of short courses (6–12 months).

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The authors declare that there are no conflicts of interest present.