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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1084</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ И ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES AND REVIEWS</subject></subj-group></article-categories><title-group><article-title>H. pylori-негативная язвенная болезнь: современное состояние проблемы</article-title><trans-title-group xml:lang="en"><trans-title>H. pylori-negative peptic ulcer: state-of-the-art</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осадчук</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Osadchuk</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Осадчук Михаил Алексеевич – доктор медицинских наук, профессор, заведующий кафедрой поликлинической терапии лечебного факультета </p></bio><bio xml:lang="en"><p>Osadchuk Michael A. – MD, PhD, professor, head of the chair of polyclinic therapy, medical faculty</p><p>119991, Moscow, Pogodinskaya street, 1, bld 1.</p></bio><email xlink:type="simple">osadchuk.mikhail@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осадчук</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Osadchuk</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Осадчук Алексей Михайлович – профессор кафедры госпитальной терапии с курсом трансфузиологии </p></bio><bio xml:lang="en"><p>Osadchuk Alexey M. – professor of chair of hospital course of internal diseases with transfusiology course</p></bio><email xlink:type="simple">maxlife2004@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сибряев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sibrjaev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сибряев Андрей Анатольевич – соискатель кафедры поликлинической терапии лечебного факультета</p></bio><bio xml:lang="en"><p>Sibrjaev Andrey A. – doctoral candidate, Chair of outpatient therapy, medical faculty</p><p>119991, Moscow, Pogodinskaya street, 1, bld 1.</p></bio><email xlink:type="simple">sibryaevaa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «Самарский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Samara state medical university», Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>07</month><year>2014</year></pub-date><volume>24</volume><issue>1</issue><fpage>4</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Осадчук М.А., Осадчук А.М., Сибряев А.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Осадчук М.А., Осадчук А.М., Сибряев А.А.</copyright-holder><copyright-holder xml:lang="en">Osadchuk M.A., Osadchuk A.M., Sibrjaev A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1084">https://www.gastro-j.ru/jour/article/view/1084</self-uri><abstract><p>Цель обзора. Представить современные данные об эпидемиологии, этиологии, патогенезе, клинике, диагностике, дифференциальной диагностике и терапии H. pylori-негативной язвенной болезни.Основные положения. Продемонстрировано нарастание числа случаев выявления такой патологии. Даны основополагающие представления об этиологии и патогенезе H. pylori-негативной язвенной болезни. Подчеркивается ее ассоциация с более тяжелым течением заболевания, частым развитием осложнений и летальностью. Раскрываются подходы к диагностике, дифференциальной диагностике и лечению.Заключение. В обзоре представлены эпидемиология, этиология, патогенез, клинические особенности H. pylori-негативной язвенной болезни. Подробно описаны существующие проблемы в этой области и возможные пути их преодоления.</p></abstract><trans-abstract xml:lang="en"><sec><title>The aim of review</title><p>The aim of review. To present modern data on epidemiology, etiology, pathogenesis, clinical presentation, diagnostics, differential diagnostics and treatment of H. pylori-negative peptic ulcer.</p></sec><sec><title>Key points</title><p>Key points. Increase in number of cases of such disorders detection is demonstrated. Basic concept on etiology and pathogenesis of H. pylori-negative peptic ulcer is presented. Its association with more severe course of disease, higher morbidity and mortality rates is emphasized. Approaches to diagnostics, differential diagnostics and treatment are revealed.</p></sec><sec><title>Conclusion</title><p>Conclusion. The review presents epidemiology, etiology, pathogenesis, clinical features of H. pylorinegative peptic ulcer. Existing problems in this area and possible ways out are described in detail.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>H. pylori-негативная язвенная болезнь</kwd><kwd>эпидемиология</kwd><kwd>этиология</kwd><kwd>патогенез</kwd><kwd>клиника</kwd><kwd>диагностика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>H. pylori-negative peptic ulcer</kwd><kwd>epidemiology</kwd><kwd>etiology</kwd><kwd>pathogenesis</kwd><kwd>clinical presentation</kwd><kwd>diagnostics</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Маев И. В., Кучерявый Ю. А., Оганесян Т. С. Аллельный полиморфизм интерлейкина-1β при геликобактериозе // Рос. журн. гастроэнтерол. гепатол. колопроктол.— 2008.— Т. 18, № 5.— С. 4–11.</mixed-citation><mixed-citation xml:lang="en">Маев И. В., Кучерявый Ю. А., Оганесян Т. С. 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