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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1093</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВОСТИ КОЛОПРОКТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEWS OF COLOPROCTOLOGY</subject></subj-group></article-categories><title-group><article-title>Характер морфологических и нейрофизиологических изменений у женщин с синдромом опущения промежности</article-title><trans-title-group xml:lang="en"><trans-title>Pattern of morphological and neurophysiologic changes in women with the syndrome of the descending perineum</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>Yu. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Titov</surname><given-names>A. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шехтер</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Shekhter</surname><given-names>A. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мудров</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mudrov</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бирюков</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Birukov</surname><given-names>O. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джанаев</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhanayev</surname><given-names>Yu. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Войнов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Voynov</surname><given-names>M. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Государственный научный центр колопроктологии» Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им И.М. Сеченова» Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>07</month><year>2014</year></pub-date><volume>24</volume><issue>1</issue><fpage>71</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шелыгин Ю.А., Титов А.Ю., Шехтер А.Б., Мудров А.А., Бирюков О.М., Джанаев Ю.А., Войнов М.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Шелыгин Ю.А., Титов А.Ю., Шехтер А.Б., Мудров А.А., Бирюков О.М., Джанаев Ю.А., Войнов М.А.</copyright-holder><copyright-holder xml:lang="en">Shelygin Y.A., Titov A.Y., Shekhter A.B., Mudrov A.A., Birukov O.M., Dzhanayev Y.A., Voynov M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1093">https://www.gastro-j.ru/jour/article/view/1093</self-uri><abstract><p>Цель исследования. Проведение морфологической оценки соединительнотканных структур промежности и выявление нейрофизилогических нарушений тазового дна у пациенток с синдромом опущения промежности (СОП).Материал и методы. Объектом исследования послужили 39 женщин в возрасте от 21 года до 68 лет с СОП, имевших клинико-инструментальные признаки синдрома опущения промежности.Выполнено сравнительное исследование строения соединительных структур у 14 пациенток с СОП – основная группа и у 10 женщин без клиникоинструментальных признаков СОП – контрольная группа. У 27 пациенток с СОП исследовались проводимость по половым нервам, латентность F-волны и потенциал двигательной активности анального сфинктера.Результаты. У обследованных основной группы выявлены изменения коллагенового каркаса кожи промежности, связок таза, стенок влагалища с заметной диссоциацией, дезорганизацией и деструкцией коллагена, что сопровождалось выраженным гиперэластозом и лимфостазом в соединительнотканных структурах промежности.У 88,8% пациенток с СОП обнаружено статистически значимое нарушение проведения электрических импульсов по половым нервам, а у 70,4% – выраженная денервация нервных волокон рефлекторной дуги от крестцового отдела позвоночника до анального сфинктера.Выводы. Наряду с отчетливыми изменениями соединительнотканных структур промежности, СОП характеризуется нейрофизилогическими нарушениями тазового дна, регистрирующимися не только в зоне периферической иннервации, но и на протяжении всей рефлекторной дуги.</p></abstract><trans-abstract xml:lang="en"><sec><title>Aim of investigation</title><p>Aim of investigation. To determine morphological rating of connective tissue structures of perineum and detect neurophysiologic disorders of pelvic floor in patients with the descending perineum syndrome (DPS).</p></sec><sec><title>Material and methods</title><p>Material and methods. Original study included 39 women with DPS in the age of 21 to 68 years, with clinical and instrumental signs of descending perineum syndrome. Comparative study of pattern of connective tissue structures in 14 DPS patients that constituted main group and in 10 women without clinical and instrumental DPS signs (control group) was carried out. In 27 DPS patients conductivity of genitofemoral nerve, F-wave latency and anal sphincter motor activity potential were investigated.</p></sec><sec><title>Results</title><p>Results. In main group changes of collagen skeleton of perineal skin, pelvic ligaments, vaginal walls with significant dissociation, disorganization and breakdown of collagen was revealed that was associated by severe hyperelastosis and lymphostasis in connective tissue structures of perineum. In 88,8% of patients with DPS statistically significant disorder of electric conductivity by genitofemoral nerves, and in 70,4% - severe denervation of reflex arch from sacral region of vertebral column to anal sphincter was revealed.</p></sec><sec><title>Conclusions</title><p>Conclusions. Along with distinct changes of connective tissue structures of perineum, DPS it is characterized by neurophysiologic disorders of pelvic floor registered not only in peripheral innervation zone, but also along the whole reflex arch.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром опущения промежности</kwd><kwd>тазовый пролапс</kwd><kwd>эстроген</kwd><kwd>коллаген</kwd><kwd>соединительная ткань</kwd><kwd>дисплазия</kwd><kwd>латентность F-волны</kwd></kwd-group><kwd-group xml:lang="en"><kwd>descending perineum syndrome</kwd><kwd>pelvic prolapse</kwd><kwd>estrogen</kwd><kwd>collagen</kwd><kwd>connective tissue</kwd><kwd>dysplasia</kwd><kwd>F-wave latency</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках федеральной целевой программы «Исследования и разработки по приоритетным направлениям развития научно-технологического комплекса России на 2007–2012 годы». 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