<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Клинические рекомендации Российской гастроэнтерологической ассоциации, Ассоциации колопроктологов России по диагностике и лечению больных с синдромом раздраженного кишечника</article-title><trans-title-group xml:lang="en"><trans-title>Clinical guidelines for the diagnosis and treatment of patients with irritable bowel syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>Ju. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранская</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranskaja</surname><given-names>E. K.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belousova</surname><given-names>E. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasil'ev</surname><given-names>S. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головенко</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovenko</surname><given-names>O. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головенко</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovenko</surname><given-names>A. O.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьев</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigor'ev</surname><given-names>E. G.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костенко</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostenko</surname><given-names>N. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашников</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashnikov</surname><given-names>V. N.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликовский</surname><given-names>В. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikovskij</surname><given-names>V. F.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапина</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapina</surname><given-names>T. L.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maev</surname><given-names>I. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полуэктова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Poluektova</surname><given-names>E. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumjancev</surname><given-names>V. G.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимербулатов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Timerbulatov</surname><given-names>V. M.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonov</surname><given-names>A. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трухманов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhmanov</surname><given-names>A. S.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фоменко</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomenko</surname><given-names>O. Ju.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халиф</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalif</surname><given-names>I. L.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубезов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Hubezov</surname><given-names>D. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чашкова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Chashkova</surname><given-names>E. Ju.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чибисов</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chibisov</surname><given-names>G. I.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шептулин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheptulin</surname><given-names>A. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шифрин</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shifrin</surname><given-names>O. S.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яновой</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Janovoj</surname><given-names>V. V.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>17</day><month>08</month><year>2014</year></pub-date><volume>24</volume><issue>2</issue><fpage>92</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Шелыгин Ю.А., Баранская Е.К., Белоусова Е.А., Васильев С.В., Головенко О.В., Головенко А.О., Григорьев Е.Г., Костенко Н.В., Кашников В.Н., Куликовский В.Ф., Лапина Т.Л., Маев И.В., Полуэктова Е.А., Румянцев В.Г., Тимербулатов В.М., Тихонов А.А., Трухманов А.С., Фоменко О.Ю., Халиф И.Л., Хубезов Д.А., Чашкова Е.Ю., Чибисов Г.И., Шептулин А.А., Шифрин О.С., Яновой В.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Шелыгин Ю.А., Баранская Е.К., Белоусова Е.А., Васильев С.В., Головенко О.В., Головенко А.О., Григорьев Е.Г., Костенко Н.В., Кашников В.Н., Куликовский В.Ф., Лапина Т.Л., Маев И.В., Полуэктова Е.А., Румянцев В.Г., Тимербулатов В.М., Тихонов А.А., Трухманов А.С., Фоменко О.Ю., Халиф И.Л., Хубезов Д.А., Чашкова Е.Ю., Чибисов Г.И., Шептулин А.А., Шифрин О.С., Яновой В.В.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Shelygin J.A., Baranskaja E.K., Belousova E.A., Vasil'ev S.V., Golovenko O.V., Golovenko A.O., Grigor'ev E.G., Kostenko N.V., Kashnikov V.N., Kulikovskij V.F., Lapina T.L., Maev I.V., Poluektova E.A., Rumjancev V.G., Timerbulatov V.M., Tikhonov A.A., Trukhmanov A.S., Fomenko O.J., Khalif I.L., Hubezov D.A., Chashkova E.J., Chibisov G.I., Sheptulin A.A., Shifrin O.S., Janovoj V.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1108">https://www.gastro-j.ru/jour/article/view/1108</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Drossman D. A. The functional gastrointestinal disorders and the Rome III Process. Gastroenterology 2006; 130 (5):1377–90.</mixed-citation><mixed-citation xml:lang="en">Drossman D. A. The functional gastrointestinal disorders and the Rome III Process. Gastroenterology 2006; 130 (5):1377–90.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cash B. D., Chey W. D. Diagnosis of irritable bowel syndrome, Gastroenterology Clinics of North America</mixed-citation><mixed-citation xml:lang="en">Cash B. D., Chey W. D. Diagnosis of irritable bowel syndrome, Gastroenterology Clinics of North America</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">; 34 (2):205–20.</mixed-citation><mixed-citation xml:lang="en">; 34 (2):205–20.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Полуэктова Е. А. Некоторые особенности патогенеза, клиники, диагностики и лечения синдрома раздраженного кишечника: Диссертация канд. мед. наук. — М., 2001.</mixed-citation><mixed-citation xml:lang="en">Полуэктова Е. А. Некоторые особенности патогенеза, клиники, диагностики и лечения синдрома раздраженного кишечника: Диссертация канд. мед. наук. — М., 2001.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В. Т., Полуэктова Е. А. Сочетание синдрома функциональной диспепсии и синдрома раздраженного кишечника. // Рос. журн. гастроэнтерол., гепатологии, колопроктол.— 2011.— № 4. — С. 75–81.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В. Т., Полуэктова Е. А. Сочетание синдрома функциональной диспепсии и синдрома раздраженного кишечника. // Рос. журн. гастроэнтерол., гепатологии, колопроктол.— 2011.— № 4. — С. 75–81.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Yarandi S. S., Christie J. Functional dyspepsia in review: pathophysiology and challenges in the diagnosis and management due to coexisting gastroesophageal reflux disease and irritable bowel syndrome. Gastroenterol Res Pract; 2013.</mixed-citation><mixed-citation xml:lang="en">Yarandi S. S., Christie J. Functional dyspepsia in review: pathophysiology and challenges in the diagnosis and management due to coexisting gastroesophageal reflux disease and irritable bowel syndrome. Gastroenterol Res Pract; 2013.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Francis C.Y, Duffy J. N., Whorwell P. J., Morris J. High prevalence of irritable bowel syndrome in patients attending urological outpatient departments. Dig Dis Sci 1997 Feb; 42 (2):404–7.</mixed-citation><mixed-citation xml:lang="en">Francis C.Y, Duffy J. N., Whorwell P. J., Morris J. High prevalence of irritable bowel syndrome in patients attending urological outpatient departments. Dig Dis Sci 1997 Feb; 42 (2):404–7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jamieson D. J., Steege J. F. The prevalence of dysmenorrhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol 1996 Jan; 87(1):55–8.</mixed-citation><mixed-citation xml:lang="en">Jamieson D. J., Steege J. F. The prevalence of dysmenorrhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol 1996 Jan; 87(1):55–8.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cho H. S., Park J. M., Lim C. H., et al. Anxiety, depression and quality of life in patients with irritable bowel syndrome. Gut Liver 2011 Mar; 5(1):29–36.</mixed-citation><mixed-citation xml:lang="en">Cho H. S., Park J. M., Lim C. H., et al. Anxiety, depression and quality of life in patients with irritable bowel syndrome. Gut Liver 2011 Mar; 5(1):29–36.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Рациональная фармакотерапия заболеваний органов пищеварения: Руководство для практикующих врачей / Под общей ред. В. Т. Ивашкина. — М., Литерра 2003.— 524 с.</mixed-citation><mixed-citation xml:lang="en">Рациональная фармакотерапия заболеваний органов пищеварения: Руководство для практикующих врачей / Под общей ред. В. Т. Ивашкина. — М., Литерра 2003.— 524 с.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Макарова И. А., Новожилов Д. Г., Хадзегова Ф. Р., Лоранская И. Д. Синдром раздраженного кишечника // Леч. дело.— 2006.— № 1. — С. 4–12.</mixed-citation><mixed-citation xml:lang="en">Макарова И. А., Новожилов Д. Г., Хадзегова Ф. Р., Лоранская И. Д. Синдром раздраженного кишечника // Леч. дело.— 2006.— № 1. — С. 4–12.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Осипенко М. Ф., Холин С. И., Рыжичкина А. Н. Хроническая абдоминальная боль и синдром раздраженного кишечника // Леч. врач.— 2011.— № 2. — С. 30–4.</mixed-citation><mixed-citation xml:lang="en">Осипенко М. Ф., Холин С. И., Рыжичкина А. Н. Хроническая абдоминальная боль и синдром раздраженного кишечника // Леч. врач.— 2011.— № 2. — С. 30–4.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Шульпекова Ю. О., Баранская Е. К. Дифференциальная диагностика синдрома раздраженного кишечника и глютеновой энтеропатии // Рос. журн. гастроэнтерол., гепатол., колопроктол.— 2009. — Т. 19, № 6. — С. 39–48.</mixed-citation><mixed-citation xml:lang="en">Шульпекова Ю. О., Баранская Е. К. Дифференциальная диагностика синдрома раздраженного кишечника и глютеновой энтеропатии // Рос. журн. гастроэнтерол., гепатол., колопроктол.— 2009. — Т. 19, № 6. — С. 39–48.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В. Т., Шептулин А. А., Шифрин О. С. и др. Микроскопический колит: клинические формы, диагностика, лечение // Рос. журн. гастроэнтерол., гепатол., колопроктол.— 2006. — Т. 16, № 6. — С. 56–60.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В. Т., Шептулин А. А., Шифрин О. С. и др. Микроскопический колит: клинические формы, диагностика, лечение // Рос. журн. гастроэнтерол., гепатол., колопроктол.— 2006. — Т. 16, № 6. — С. 56–60.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pimentel M., Chow E. J., Lin H. C. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a doubleblind, randomized, placebo-controlled study. Am J Gastroenterol. 2003 Feb; 98(2):412–9.</mixed-citation><mixed-citation xml:lang="en">Pimentel M., Chow E. J., Lin H. C. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a doubleblind, randomized, placebo-controlled study. Am J Gastroenterol. 2003 Feb; 98(2):412–9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Adeniji O. A., Barnett C. B., di Palma J. A. Durability of the diagnosis of irritable bowel syndrome based on clinical criteria, Dig Dis Sci 2004. 49(4):572–4.</mixed-citation><mixed-citation xml:lang="en">Adeniji O. A., Barnett C. B., di Palma J. A. Durability of the diagnosis of irritable bowel syndrome based on clinical criteria, Dig Dis Sci 2004. 49(4):572–4.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes J. When to investigate and treat IBS symptoms, Practitioner, 1996, 240(1560):184–7.</mixed-citation><mixed-citation xml:lang="en">Barnes J. When to investigate and treat IBS symptoms, Practitioner, 1996, 240(1560):184–7.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bellini M., Tosetti C., Costa F., et al. The general practitioner’s approach to irritable bowel syndrome: from intention to practice, Dig Liver Di 2005; 37(12):934–9.</mixed-citation><mixed-citation xml:lang="en">Bellini M., Tosetti C., Costa F., et al. The general practitioner’s approach to irritable bowel syndrome: from intention to practice, Dig Liver Di 2005; 37(12):934–9.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">World Gastroenterology Organisation, 2009. Irritable bowel syndrome: the global perspective (Clinical guideline).</mixed-citation><mixed-citation xml:lang="en">World Gastroenterology Organisation, 2009. Irritable bowel syndrome: the global perspective (Clinical guideline).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Рациональная фармакотерапия заболеваний органов пищеварения: Руководство для практикующих врачей / Под общей ред. В. Т. Ивашкина. — М.: Литерра, 2003. — С. 524–5.</mixed-citation><mixed-citation xml:lang="en">Рациональная фармакотерапия заболеваний органов пищеварения: Руководство для практикующих врачей / Под общей ред. В. Т. Ивашкина. — М.: Литерра, 2003. — С. 524–5.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Jones J., Boorman J., Cann P., et al. British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome, Gut 2000; 47, Suppl 2: ii1–19.</mixed-citation><mixed-citation xml:lang="en">Jones J., Boorman J., Cann P., et al. British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome, Gut 2000; 47, Suppl 2: ii1–19.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">National Collaborating Centre for Nursing and Supportive Care, National Institute for Health and Clinical Excellence (NICE). Diagnosis and management of irritable bowel syndrome in primary care; 2008 Feb.</mixed-citation><mixed-citation xml:lang="en">National Collaborating Centre for Nursing and Supportive Care, National Institute for Health and Clinical Excellence (NICE). Diagnosis and management of irritable bowel syndrome in primary care; 2008 Feb.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Burden S. Dietary treatment of irritable bowel syndrome: Current evidence and guidelines for future practice, J Human Nutrition Dietetics, 2001; 14(3):231–41.</mixed-citation><mixed-citation xml:lang="en">Burden S. Dietary treatment of irritable bowel syndrome: Current evidence and guidelines for future practice, J Human Nutrition Dietetics, 2001; 14(3):231–41.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Aller R., de Luis D. A., Izaola O., et al. Effects of a high-fiber diet on symptoms of irritable bowel syndrome: a randomized clinical trial, Nutrition 2004; 20(9):735–7.</mixed-citation><mixed-citation xml:lang="en">Aller R., de Luis D. A., Izaola O., et al. Effects of a high-fiber diet on symptoms of irritable bowel syndrome: a randomized clinical trial, Nutrition 2004; 20(9):735–7.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Vesa T.H, Seppo L. M., Martea P. R., et al. Role of irritable bowel syndrome in subjective lactose intolerance. Am J Clin Nutrition 1998; 67(4):710–5.</mixed-citation><mixed-citation xml:lang="en">Vesa T.H, Seppo L. M., Martea P. R., et al. Role of irritable bowel syndrome in subjective lactose intolerance. Am J Clin Nutrition 1998; 67(4):710–5.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson W., Sheldon T. A., Shaath N., Whorwell P. J. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial., Gut. 2004; 53(10):1459–64.</mixed-citation><mixed-citation xml:lang="en">Atkinson W., Sheldon T. A., Shaath N., Whorwell P. J. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial., Gut. 2004; 53(10):1459–64.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">De Schryver A. M., Keulemans Y. C., Peters H. P., et al. Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation. Scandinavian J Gastroenterol 2005; 40(4):422–9.</mixed-citation><mixed-citation xml:lang="en">De Schryver A. M., Keulemans Y. C., Peters H. P., et al. Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation. Scandinavian J Gastroenterol 2005; 40(4):422–9.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bi L., Triadafilopoulos G. Exercise and gastrointestinal function and disease: an evidence based review of risks and benefits. Clinical Gastroenterol Hepatol 2003; 1(5):345–55.</mixed-citation><mixed-citation xml:lang="en">Bi L., Triadafilopoulos G. Exercise and gastrointestinal function and disease: an evidence based review of risks and benefits. Clinical Gastroenterol Hepatol 2003; 1(5):345–55.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cash B. D., Chey W. D. Irritable bowel syndrome: A systematic review, Clinics in Family Practice 2004; 6(3):647–69.</mixed-citation><mixed-citation xml:lang="en">Cash B. D., Chey W. D. Irritable bowel syndrome: A systematic review, Clinics in Family Practice 2004; 6(3):647–69.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ардатская М. Д., Минушкин О. Н. Патогенетическое лечение синдрома раздраженного кишечника // Фарматека.— 2012. – № 7. — С. 18–25.</mixed-citation><mixed-citation xml:lang="en">Ардатская М. Д., Минушкин О. Н. Патогенетическое лечение синдрома раздраженного кишечника // Фарматека.— 2012. – № 7. — С. 18–25.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Полуэктова Е. А., Кучумова С. Ю., Шептулин А. А., Ивашкин В. Т. Лечение синдрома раздраженного кишечника с позиций современных представлений о патогенезе заболевания // Рос журн гастроэнтерол гепатол колопроктол. — 2013. — Т. 23, № 1. — С. 57–65.</mixed-citation><mixed-citation xml:lang="en">Полуэктова Е. А., Кучумова С. Ю., Шептулин А. А., Ивашкин В. Т. Лечение синдрома раздраженного кишечника с позиций современных представлений о патогенезе заболевания // Рос журн гастроэнтерол гепатол колопроктол. — 2013. — Т. 23, № 1. — С. 57–65.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Осипенко М. Ф., Бикбулатова Е. А., Фролова Н. Н., Лосева Н. В. Комплексная терапия больных с синдромом раздраженного кишечника // Экспер. клин. гастроэнтерол.— 2004.— № 5. — С. 39–44.</mixed-citation><mixed-citation xml:lang="en">Осипенко М. Ф., Бикбулатова Е. А., Фролова Н. Н., Лосева Н. В. Комплексная терапия больных с синдромом раздраженного кишечника // Экспер. клин. гастроэнтерол.— 2004.— № 5. — С. 39–44.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sackett D. L., Strauss S. E., Richardson W. S., et al. Evidence-Based Medicine: How to Practice and Teach EBM. Philadelphia, Pa: Churchill-Livingstone; 2000.</mixed-citation><mixed-citation xml:lang="en">Sackett D. L., Strauss S. E., Richardson W. S., et al. Evidence-Based Medicine: How to Practice and Teach EBM. Philadelphia, Pa: Churchill-Livingstone; 2000.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ford A. C., Talley N. J., Spiegel B. M., et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis // BMJ 2008 Nov 13: 337.</mixed-citation><mixed-citation xml:lang="en">Ford A. C., Talley N. J., Spiegel B. M., et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis // BMJ 2008 Nov 13: 337.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ruepert I. et al., The Cochraine Library 2013, Issue 3.</mixed-citation><mixed-citation xml:lang="en">Ruepert I. et al., The Cochraine Library 2013, Issue 3.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Lesbros-Pantoflickova D., Michetti P., et al. Metaanalysis: the treatment of irritable bowel syndrome. Alim Pharm / Ther Dec 2004; 20, Issue 11–12: 1253–69.</mixed-citation><mixed-citation xml:lang="en">Lesbros-Pantoflickova D., Michetti P., et al. Metaanalysis: the treatment of irritable bowel syndrome. Alim Pharm / Ther Dec 2004; 20, Issue 11–12: 1253–69.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Chang F. Y., Lu C. L., Chen C. Y., Luo J. C. Efficacy of dioctahedral smectite in treating patients of diarrheapredominant irritable bowel syndrome. J Gastroenterol Hepatol 2007; 22(12):2266–72.</mixed-citation><mixed-citation xml:lang="en">Chang F. Y., Lu C. L., Chen C. Y., Luo J. C. Efficacy of dioctahedral smectite in treating patients of diarrheapredominant irritable bowel syndrome. J Gastroenterol Hepatol 2007; 22(12):2266–72.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Menees S. B., Maneerattannaporn M., Kim H. M., Chey W. D. The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta analysis. Am J Gastroenterol 2012 Jan; 107(1):28–35.</mixed-citation><mixed-citation xml:lang="en">Menees S. B., Maneerattannaporn M., Kim H. M., Chey W. D. The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta analysis. Am J Gastroenterol 2012 Jan; 107(1):28–35.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов А. И., Ручкина И. Н., Осипов Г. А. Висмута трикалия дицитрат в лечении больных постинфекционным СРК с преобладанием диареи // Рус. мед. журн.— 2006.— № 2. — Прил. «Болезни органов пищеварения». — С. 3–6.</mixed-citation><mixed-citation xml:lang="en">Парфенов А. И., Ручкина И. Н., Осипов Г. А. Висмута трикалия дицитрат в лечении больных постинфекционным СРК с преобладанием диареи // Рус. мед. журн.— 2006.— № 2. — Прил. «Болезни органов пищеварения». — С. 3–6.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Schindlbeck N. E., Müller-Lissner S. A. Dietary fiber. Indigestible dietary plant constituents and colon function. Med Monatsschr Pharm 1988 Oct; 11 (10): 331–6.</mixed-citation><mixed-citation xml:lang="en">Schindlbeck N. E., Müller-Lissner S. A. Dietary fiber. Indigestible dietary plant constituents and colon function. Med Monatsschr Pharm 1988 Oct; 11 (10): 331–6.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Ford A. C., Talley N. J., Spiegel B. M.R., et al. Effect of fibre, antispasmodics and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. Br Med J 2008; 337.</mixed-citation><mixed-citation xml:lang="en">Ford A. C., Talley N. J., Spiegel B. M.R., et al. Effect of fibre, antispasmodics and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. Br Med J 2008; 337.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Müller-Lissner S., et al. Diagnosis and treatment of chronic constipation — a European perspective. Neurogastroenterol Motil 2011 Aug; 23(8):697–710.</mixed-citation><mixed-citation xml:lang="en">Tack J., Müller-Lissner S., et al. Diagnosis and treatment of chronic constipation — a European perspective. Neurogastroenterol Motil 2011 Aug; 23(8):697–710.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller-Lissner S., Kamm M. A., et al. Multicenter, 4-week, double-blind, randomized, placebo-controlledtrial of sodium picosulfate in patients with chronic constipation Am J Gastroenterol. 2010 Apr; 105(4):897–903.</mixed-citation><mixed-citation xml:lang="en">Mueller-Lissner S., Kamm M. A., et al. Multicenter, 4-week, double-blind, randomized, placebo-controlledtrial of sodium picosulfate in patients with chronic constipation Am J Gastroenterol. 2010 Apr; 105(4):897–903.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Bengtsson M., Ohlsson B. Psychological well-being and symptoms in women with chronic constipation treated with sodium picosulphate. Gastroenterol Nurs 2005 JanFeb; 28(1):3–12.</mixed-citation><mixed-citation xml:lang="en">Bengtsson M., Ohlsson B. Psychological well-being and symptoms in women with chronic constipation treated with sodium picosulphate. Gastroenterol Nurs 2005 JanFeb; 28(1):3–12.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Delvaux M., Wingate D. Trimebutine: mechanism of action, effects on gastrointestinal function and clinical results. J Int Med Res 1997 Sep-Oct; 25(5):225–46.</mixed-citation><mixed-citation xml:lang="en">Delvaux M., Wingate D. Trimebutine: mechanism of action, effects on gastrointestinal function and clinical results. J Int Med Res 1997 Sep-Oct; 25(5):225–46.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Zhong Y. Q., et al. A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndromе. ZhonghuaNeiKeZaZhi. 2007 Nov; 46(11):899–902.</mixed-citation><mixed-citation xml:lang="en">Zhong Y. Q., et al. A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndromе. ZhonghuaNeiKeZaZhi. 2007 Nov; 46(11):899–902.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wittmann T., et al. Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome — a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2010 Mar; 31 (6):615–24.</mixed-citation><mixed-citation xml:lang="en">Wittmann T., et al. Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome — a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2010 Mar; 31 (6):615–24.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Bittner A. C., Croffut R. M., Stranahan M. C. Prescript-assist probiotic-prebiotic treatment for irritable bowel syndrome: A methodologically oriented, 2-week, randomized, placebo-controlled, double-blind clinical study, Clinical Therapeutics 2005, 27(6):755–61.</mixed-citation><mixed-citation xml:lang="en">Bittner A. C., Croffut R. M., Stranahan M. C. Prescript-assist probiotic-prebiotic treatment for irritable bowel syndrome: A methodologically oriented, 2-week, randomized, placebo-controlled, double-blind clinical study, Clinical Therapeutics 2005, 27(6):755–61.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H. J., Camilleri M., McKinzie S., et al. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoeapredominant irritable bowel syndrome. Aliment Pharmacol Ther 2003; 17(7):895–904.</mixed-citation><mixed-citation xml:lang="en">Kim H. J., Camilleri M., McKinzie S., et al. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoeapredominant irritable bowel syndrome. Aliment Pharmacol Ther 2003; 17(7):895–904.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H. J., Vazquez Roque M. I., Camilleri M., et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil 2005; 17(5):687–96.</mixed-citation><mixed-citation xml:lang="en">Kim H. J., Vazquez Roque M. I., Camilleri M., et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil 2005; 17(5):687–96.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Niedzielin K., Kordecki H., Birkenfeld B. A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 2001; 13(10):1143–7.</mixed-citation><mixed-citation xml:lang="en">Niedzielin K., Kordecki H., Birkenfeld B. A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 2001; 13(10):1143–7.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Ford A. C., Talley N. J., Schoenfeld P. S., et al. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and metaanalysis. Gut 2009 Mar; 58(3):367–78.</mixed-citation><mixed-citation xml:lang="en">Ford A. C., Talley N. J., Schoenfeld P. S., et al. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and metaanalysis. Gut 2009 Mar; 58(3):367–78.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Corney R. H., Stanton R., Newell R., et al. Behavioural psychotherapy in the treatment of irritable bowel syndrome. J Psychosomatic Res 1991; 35(4–5):461–9.</mixed-citation><mixed-citation xml:lang="en">Corney R. H., Stanton R., Newell R., et al. Behavioural psychotherapy in the treatment of irritable bowel syndrome. J Psychosomatic Res 1991; 35(4–5):461–9.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Drossman D. A., Toner B. B., Whitehead W. E., et al. Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003, 125(1):19–31.</mixed-citation><mixed-citation xml:lang="en">Drossman D. A., Toner B. B., Whitehead W. E., et al. Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003, 125(1):19–31.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Heymann-Monnikes I., Arnold R., Florin I., et al. The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowel syndrome. Am J Gastroenterol 2000; 95(4):981–94.</mixed-citation><mixed-citation xml:lang="en">Heymann-Monnikes I., Arnold R., Florin I., et al. The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowel syndrome. Am J Gastroenterol 2000; 95(4):981–94.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Forbes A., MacAuley S., Chiotakakou-Faliakou E. Hypnotherapy and therapeutic audiotape: effective in previously unsuccessfully treated irritable bowel syndrome? Int J Colorectal Dis 2000; 15(5–6):328–34.</mixed-citation><mixed-citation xml:lang="en">Forbes A., MacAuley S., Chiotakakou-Faliakou E. Hypnotherapy and therapeutic audiotape: effective in previously unsuccessfully treated irritable bowel syndrome? Int J Colorectal Dis 2000; 15(5–6):328–34.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Bergeron C. M. A comparison of cognitive stress management, progressive muscle relaxation, and biofeedback in the treatment of irritable bowel syndrome. Dis. Abstracts Int 1984; 44(10-B):3186.</mixed-citation><mixed-citation xml:lang="en">Bergeron C. M. A comparison of cognitive stress management, progressive muscle relaxation, and biofeedback in the treatment of irritable bowel syndrome. Dis. Abstracts Int 1984; 44(10-B):3186.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Blanchard E. B., Schwarz S. P., Suls J. M., et al. Two controlled evaluations of multicomponent psychological treatment of irritable bowel syndrome. Behaviour Res Ther 1992; 30(2):175–89.</mixed-citation><mixed-citation xml:lang="en">Blanchard E. B., Schwarz S. P., Suls J. M., et al. Two controlled evaluations of multicomponent psychological treatment of irritable bowel syndrome. Behaviour Res Ther 1992; 30(2):175–89.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Bogalo L., Moss-Morris R. The effectiveness of homework tasks in an irritable bowel syndrome cognitive behavioural self-management programme. New Zealand J Psychology 2006; 35(3):120–5.</mixed-citation><mixed-citation xml:lang="en">Bogalo L., Moss-Morris R. The effectiveness of homework tasks in an irritable bowel syndrome cognitive behavioural self-management programme. New Zealand J Psychology 2006; 35(3):120–5.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Forbes A., Jackson S., Walter C., et al. Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial. World J Gastroenterol 2005; 11(26):4040–4.</mixed-citation><mixed-citation xml:lang="en">Forbes A., Jackson S., Walter C., et al. Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial. World J Gastroenterol 2005; 11(26):4040–4.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Юрманова Е. Н. Отдаленные результаты лечения и прогноз пациентов с синдромом раздраженного кишечника. Дис. канд. мед. наук. — М., 2007.</mixed-citation><mixed-citation xml:lang="en">Юрманова Е. Н. Отдаленные результаты лечения и прогноз пациентов с синдромом раздраженного кишечника. Дис. канд. мед. наук. — М., 2007.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Harvey R. F., Mauad E. C., Brown A. M. Prognosis in the irritable bowel syndrome: a 5-year prospective study. Lancet 1987; 1(8539):963–5.</mixed-citation><mixed-citation xml:lang="en">Harvey R. F., Mauad E. C., Brown A. M. Prognosis in the irritable bowel syndrome: a 5-year prospective study. Lancet 1987; 1(8539):963–5.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
