gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1119Research ArticleНОВОСТИ КОЛОПРОКТОЛОГИИNEWS OF COLOPROCTOLOGYПатогенетическое значение изменений кишечной микрофлоры у больных с синдромом раздраженного кишечника и возможности их коррекцииPathogenic role of intestinal microflora changes in patients with irritable bowel syndrome and treatment optionsПолуэктоваЕ. А.PoluektovaYe. A.

Полуэктова Елена Александровна — кандидат медицинских наук, ведущий научный сотрудник НИО инновационной терапии, врач отделения хронических заболеваний кишечника и поджелудочной железы

119991, Москва, ул. Погодинская, д.1, стр. 1

Poluektova Yelena A — MD, leading research associate of Scientific Research Department of innovative therapy, doctor of department of chronic bowel and pancreatic diseases

119991, Moscow, Pogodinskaya street, 1, bld 1

polouektova@rambler.ruКучумоваС. Ю.KuchumovaS. Yu.ШифринО. С.ShifrinO. S.ШептулинА. А.SheptulinA. A.ИвашкинВ. Т.IvashkinV. T.ГБОУ ВПО «Первый  Московский  государственный  медицинский  университет» им И. М. Сеченова Минздрава РоссииРоссияState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Healthcare of RussiaRussian Federation2014170420242438997Copyright © Полуэктова Е.А., Кучумова С.Ю., Шифрин О.С., Шептулин А.А., Ивашкин В.Т., 20142014Полуэктова Е.А., Кучумова С.Ю., Шифрин О.С., Шептулин А.А., Ивашкин В.Т.Poluektova Y.A., Kuchumova S.Y., Shifrin O.S., Sheptulin A.A., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1119

Цель обзора. Провести анализ публикаций, посвященных изучению изменений качественного и количественного состава кишечной микрофлоры у больных с синдромом раздраженного кишечника (СРК) и возможностям его коррекции с применением пре-, про-, и симбиотических препаратов.Основные положения. В последние годы появляется все больше сведений, свидетельствующих о нарушении качественного и количественного состава кишечной микрофлоры в сочетании с воспалительными изменениями низкой степени активности слизистой оболочки толстой кишки у больных с СРК, что позволило пересмотреть стандартные представления о патогенезе данного функционального расстройства. Препараты, восстанавливающие баланс кишечной микрофлоры, эффективны для купирования симптомов рассматриваемого заболевания.Заключение. Анализ информации, касающейся нарушения качественного и количественного состава кишечной микрофлоры у больных с СРК, механизмов действия пре-, про и синбиотиков, позволяет существенно расширить возможности лечения данного заболевания.

The aim of review

The aim of review. To analyse of publications on qualitative and quantitative changes in pattern of intestinal microflora in patients with irritable bowel syndrome (IBS) and options of its treatment by pre-, pro-, and symbiotic drugs.

Key points

Key points. In the last years more and more data appear on changes in qualitative and quantitative spectrum of intestinal microflora in combination to low degree inflammation of colonic mucosa at IBS that allowed to reconsider standard concepts on pathogenesis of this functional disorder. Agents restoring intestinal microflora balance are effective for symptom relief of this disease.

Conclusion

Conclusion. The analysis of the information concerning disorder of qualitative and quantitative structure of intestinal microflora at IBS, mechanisms of action of pre-, pro- and synbiotics, allows to expand essentially treatment options of this disease.

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The authors declare that there are no conflicts of interest present.