gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1198Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSАутоиммунный панкреатит – особая форма хронического панкреатитаAutoimmune pancreatitis – the special form of chronic pancreatitisЦиммерманЯ. С.TsimmermanYa. S.

Циммерман Яков Саулович – заслуженный деятель науки РФ, доктор медицинских наук, профессор кафедры факультетской терапии 

614990, г. Пермь, ул. Куйбышева, 39

Tsimmerman Yacob S. – Honored scientist of the Russian Federation, MD, PhD, professor of chair of faculty therapy

614990, Perm, Kuybyshev street, 39

chief@psma.ruГБОУ ВПО «Пермская государственная медицинская академия им. Е.А. Вагнера» Минздрава РоссииРоссияState educational state-funded institution of higher professional education «Wagner Perm state medical academy», Ministry of Healthcare of the Russian FederationRussian Federation201320072013233915Copyright © Циммерман Я.С., 20132013Циммерман Я.С.Tsimmerman Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1198

Цель обзора. Представить особенности клиники, диагностики и лечения отдельной формы хронического панкреатита – аутоиммунного панкреатита (АИП).Основные положения. Этиология АИП недостаточно изучена, рассматривается роль инфекции (в частности, вирусной), антигенного повреждения панкреатических протоков и ацинарных клеток. АИП часто сочетается с другими аутоиммунными заболеваниями. Наиболее характерным серологическим маркёром АИП является повышение уровня IgG4 в сыворотке крови. В настоящее время выделяют 2 типа АИП, причем АИП второго типа требует обязательного морфологического подтверждения. АИП характеризуется хорошим ответом на терапию кортикостероидами.Заключение. Проблема АИП продолжает оставаться актуальной и требует проведения дальнейших исследований.

The aim of review

The aim of review. To present features of clinical presentation, diagnostics and treatment of special form of chronic pancreatitis – autoimmune pancreatitis (AIP).

Key points

Key points. The etiology of AIP is investigated insufficiently, the role of infection (in particular, viral), antigenic damage of pancreatic ducts and acinar cells is considered. AIP is frequently combined to other autoimmune diseases. The most typical serological marker of AIP is elevation of serum IgG4 level. Now 2 types of AIP are defined. AIP of the second type requires mandatory morphological confirmation. AIP is characterized by good treatment response by corticosteroids.

Conclusion

Conclusion. The issue of AIP remains actual and requires further studies.

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The authors declare that there are no conflicts of interest present.