gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1254Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSСаркопения как ведущий компонент синдрома раковой кахексииSarcopenia as a leading component of malignant cachexia syndromeЛядовВ. К.LyadovV. K.БулановаЕ. А.BulanovaE. A.СеряковА. П.SeryakovA. P.ФГУ «Лечебно-реабилитационный центр Минздравсоцразвития РФ»Russian Federation20121002201222148Copyright © Лядов В.К., Буланова Е.А., Серяков А.П., 20122012Лядов В.К., Буланова Е.А., Серяков А.П.Lyadov V.K., Bulanova E.A., Seryakov A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1254

Цель обзора. Проанализировать накопленные в мировой литературе данные о значении истощения скелетной мускулатуры, или саркопении, в развитии синдрома раковой кахексии, а также о диагностике и клиническом значении данного состояния.Основные положения. Синдром кахексии является одним из наиболее часто встречающихся последствий раковой болезни. В последние годы показано, что саркопения играет ведущую роль в патогенезе и развитии указанного состояния.В диагностике саркопении могут применяться различные методики, включая антропометрию, биоимпедансный анализ, двухэнергетическую рентгеновскую абсорбциометрию. Однако наибольшее значение для этой цели приобретают результаты компьютерной и магнитно-резонансной томографии.В статье подробно освещены как методические аспекты анализа состава тела с помощью лучевых методов исследования, так и различные сведения о клиническом значении саркопении. Предлагаются перспективные направления научных исследований в данной области.Заключение. Саркопения является важной составляющей синдрома раковой кахексии. Ее изучение представляется перспективным направлением клинических исследований в онкологии.

The aim of review

The aim of review. To analyze cumulative data of the global literature on skeletal musculature depletion or sarcopenia, in development of malignant cachexia syndrome, as well as diagnostics and clinical value of this state.

Original points

Original points. Cachexia syndrome is one of the most frequent consequences of malignant disease. In the last years it was demonstrated, that sarcopenia plays the leading role in pathogenesis and progression of this state. Various procedures, including anthropometry, bioimpedance analysis, dual photon X-ray absorptiometry can be applied in diagnostics of sarcopenia. However, computer and magnetic-resonance tomography have the highest value for this goal. The article presents in detail data on clinical value of sarcopenia along with academical aspects of body composition analysis by radiological methods. Perspective trends of scientific studies in this area are proposed.

Conclusion

Conclusion. Sarcopenia is the important component of malignant cachexia syndrome. Its investigation is perspective trend in clinical studies in oncology.

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The authors declare that there are no conflicts of interest present.