gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1281Research ArticleНАЦИОНАЛЬНАЯ ШКОЛА ГАСТРОЭНТЕРОЛОГОВ, ГЕПАТОЛОГОВNATIONAL COLLEGE OF GASTROENTEROLOGISTS, HEPATOLOGISTSИнфекция Helicobacter pylori и рак желудка: современное состояние проблемыInfection Helicobacter pylori and stomach cancer: state-of-the-artШептулинА. А.SheptulinA. A.Первый Московский государственный медицинский университет им. И.М. СеченоваRussian Federation2012170420122227782Copyright © Шептулин А.А., 20122012Шептулин А.А.Sheptulin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1281

Цель обзора. Провести анализ публикаций, посвященных проблеме взаимосвязи инфекции Helicobacter pylori и рака желудка (РЖ).Основные положения. Имеющиеся данные убедительно подтверждают, что инфекция Н. pylori повышает риск развития РЖ, однако в тесном взаимодействии с факторами макроорганизма – генетическими, особенностями питания и др. Эрадикация Н. pylori приводит к уменьшению выраженности атрофического гастрита, но не влияет на процессы кишечной метаплазии. В настоящее время ее проведение показано пациентам с высоким риском развития РЖ (с атрофическим гастритом, после резекций по поводу раннего РЖ, родственникам больных РЖ первой степени родства).Заключение. Патофизиологические и клинические аспекты взаимоотношений между инфекцией Н. pylori и РЖ требуют дальнейших исследований.

The aim of review

The aim of review. To carry out analysis of the publications devoted to Helicobacter pylori infection and stomach cancer (SC) interrelation.

Original positions

Original positions. Available data convincingly confirm that Н. pylori infection increases risk of SC development, however in close interaction with host factors – genetic factors, dietary habits, etc. Eradication of Н. pylori results in decrease of atrophic gastritis severity, but does not affect intestinal metaplasia process. Nowadays it is indicated for patients with high risk of SC (having atrophic gastritis, postgastrectomy patients for early SC, first-degree relatives of patients with SC).

Conclusion

Conclusion. Pathophysiological and clinical aspects of interrelations between Н. pylori infection and SC require the further studies.

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The authors declare that there are no conflicts of interest present.