gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1302Research ArticleНАЦИОНАЛЬНАЯ ШКОЛА ГАСТРОЭНТЕРОЛОГОВ, ГЕПАТОЛОГОВNATIONAL COLLEGE OF GASTROENTEROLOGISTS, HEPATOLOGISTSПробиотики и продукты функционального питанияProbiotics and functional nutrition productsШульпековаЮ. О.ShulpekovaYu. О.ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РоссииРоссияState educational government-financed institution of higher professional education Sechenov First Moscow state medical university of the Russian federation Ministry of Health and Social DevelopmentRussian Federation2012260620122237079Copyright © Шульпекова Ю.О., 20122012Шульпекова Ю.О.Shulpekova Y.О.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1302

Цель обзора. Охарактеризовать лечебно­профилактическое действие пробиотиков, понятие «функционального питания» и его значение в структуре питания человека.Основное содержание. Лечебные и профилактические эффекты пробиотиков включают повышение устойчивости к инфекционным заболеваниям кишечника и дыхательных путей, предупреждение и сокращение продолжительности диареи, улучшение переносимости лактозы, лечение запора, уменьшение наклонности к атопическим реакциям и др. Применяемые штаммы могут оказывать прямое действие на проницаемость кишечного барьера и звенья иммунитета: повышают выработку иммуноглобулина А, влияют на активность фагоцитов и натуральных киллеров, выработку цитокинов, на сигнальные внутриклеточные молекулы. Некоторые лечебные штаммы снижают риск атопических реакций.Штаммы, зарекомендовавшие себя как эффективные средства профилактики широко распространенных заболеваний, включают в состав функциональных продуктов питания. Кисломолочный продукт, обогащенный L. casei DN-114001 Imunitass, в контролируемых клинических исследованиях показал защитный эффект применительно к наиболее распространенным инфекционным заболеваниям.Пробиотический кисломолочный продукт, обогащенный B. animalis DN-173 010 (ActiRegularis), имеет весомую доказательную базу в отношении положительного влияния на частоту стула.Заключение. Применение пробиотиков имеет большие перспективы как «физиологичный» и безопасный способ стимуляции защитных резервов организма. Один из путей более широкой «эксплуатации» профилактического действия – включение в состав кисломолочных продуктов для ежедневного потребления.

The aim of review

The aim of review. To characterize treatment-andprophylactic effect of probiotics, concept of «functional nutrition» and its value in the pattern of human nutrition.

Main contents

Main contents. Medical and prophylactic effects of probiotics include increase of resistance to infectious diseases of intestine and respiratory tract, prevention and decrease of diarrhea duration, improvement of lactose tolerance, treatment of constipation, decrease of atopic reactions tendency, etc. Used strains can have direct effect on permeability of intestinal barrier and immunodefence components: increase of immunoglobulin A production, modify activity of phagocytes and natural killers, cytokine production and signaling endocellular molecules. Some medical strains reduce risk of atopic reactions. Strains, proven as effective agents for prophylaxis of widespread diseases, are added to functional nutrients. Fermented-milk product enriched by L. casei DN-114001 Imunitass, in controlled clinical studies demonstrated protective effect for the most of common infectious diseases. The probiotic fermented-milk product enriched by B. animalis DN-173 010 (ActiRegularis), has convincing evidential base for positive effect on frequency of bowel movements.

Conclusion

Conclusion. Application of probiotics has major prospects as «physiologic» and safe method of stimulation of protective body resources. One of the ways to provide wider «operation» of preventive effect – is addition to fermented-milk products for daily intake.

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The authors declare that there are no conflicts of interest present.