<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1303</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению функциональной диспепсии</article-title><trans-title-group xml:lang="en"><trans-title>Guidelines of the Russian gastroenterological association on diagnostics and treatment of functional dyspepsia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шептулин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheptulin</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапина</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapina</surname><given-names>T. L.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Картавенко</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kartavenko</surname><given-names>I. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киприанис</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiprianis</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Охлобыстина</surname><given-names>О. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Okhlobystina</surname><given-names>O. Z.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новожилов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Novozhilov</surname><given-names>N. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Health and Social Development of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>26</day><month>06</month><year>2012</year></pub-date><volume>22</volume><issue>3</issue><fpage>80</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Шептулин А.А., Лапина Т.Л., Картавенко И.М., Киприанис В.А., Охлобыстина О.З., Новожилов Н.В., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Шептулин А.А., Лапина Т.Л., Картавенко И.М., Киприанис В.А., Охлобыстина О.З., Новожилов Н.В.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Sheptulin A.A., Lapina T.L., Kartavenko I.M., Kiprianis V.A., Okhlobystina O.Z., Novozhilov N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1303">https://www.gastro-j.ru/jour/article/view/1303</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Шептулин А.А., Трухманов А.С. Эффективность применения ганатона (итоприда гидрохлорида) в лечении больных функциональной диспепсией // Фарматека. – 2009. – № 13. – С. 50–54.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В.Т., Шептулин А.А., Трухманов А.С. Эффективность применения ганатона (итоприда гидрохлорида) в лечении больных функциональной диспепсией // Фарматека. – 2009. – № 13. – С. 50–54.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Картавенко И.М. Морфофункциональная оценка двенадцатиперстной кишки у лиц с функциональной диспепсией: Автореф. дис. ... канд. мед. наук. – М., 2008. – 23 с.</mixed-citation><mixed-citation xml:lang="en">Картавенко И.М. Морфофункциональная оценка двенадцатиперстной кишки у лиц с функциональной диспепсией: Автореф. дис. ... канд. мед. наук. – М., 2008. – 23 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Охлобыстина О.З. Некоторые особенности патогенеза, клиники, диагностики и лечения синдрома функциональной диспепсии: Автореф. дис. ... канд. мед. наук. – М., 2007. – 24 с.</mixed-citation><mixed-citation xml:lang="en">Охлобыстина О.З. Некоторые особенности патогенеза, клиники, диагностики и лечения синдрома функциональной диспепсии: Автореф. дис. ... канд. мед. наук. – М., 2007. – 24 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Пюрвеева К.В., Лапина Т.Л., Ивашкин В.Л. и др. Значение сывороточных показателей пепсиногена I, пепсиногена II и гастрина-17 в диагностике атрофического гастрита // Рос. журн. гастроэнтерол. гепатол. колопроктол. – 2005. – Т. 15, № 3. – С.48–51.</mixed-citation><mixed-citation xml:lang="en">Пюрвеева К.В., Лапина Т.Л., Ивашкин В.Л. и др. Значение сывороточных показателей пепсиногена I, пепсиногена II и гастрина-17 в диагностике атрофического гастрита // Рос. журн. гастроэнтерол. гепатол. колопроктол. – 2005. – Т. 15, № 3. – С.48–51.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Allescher H.-D., Böckenhoff A., Knapp G. et al. Treatment of non-ulcer dyspepsia: a meta-analysis of placebo-controlled prospective studies // Scand. J. Gastroenterol. – 2001. – Vol. 36. – P. 934–941.</mixed-citation><mixed-citation xml:lang="en">Allescher H.-D., Böckenhoff A., Knapp G. et al. Treatment of non-ulcer dyspepsia: a meta-analysis of placebo-controlled prospective studies // Scand. J. Gastroenterol. – 2001. – Vol. 36. – P. 934–941.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Amarapurkar D.N., Rank P. Randomized, double-blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia // J. Indian Med. Assoc. – 2004. – Vol. 102. – P. 735–760.</mixed-citation><mixed-citation xml:lang="en">Amarapurkar D.N., Rank P. Randomized, double-blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia // J. Indian Med. Assoc. – 2004. – Vol. 102. – P. 735–760.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bazolli F. Choice of first line treatments to optimise eradication // H. pylori resistance and management strategies. – World Congress of Gastroenterology. – Montreal, 2005 (oral presentation).</mixed-citation><mixed-citation xml:lang="en">Bazolli F. Choice of first line treatments to optimise eradication // H. pylori resistance and management strategies. – World Congress of Gastroenterology. – Montreal, 2005 (oral presentation).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Boekema P.J., van Dam E.F., Bots M.L. et al. Associations between use of alcohol, coffee and smoking and functional bowel symptoms in the general dutch population // DDW – New Orleans, 1998. – Abstract A1070.</mixed-citation><mixed-citation xml:lang="en">Boekema P.J., van Dam E.F., Bots M.L. et al. Associations between use of alcohol, coffee and smoking and functional bowel symptoms in the general dutch population // DDW – New Orleans, 1998. – Abstract A1070.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Buckley M., O′Morain C. Prevalence of Helicobacter pylori in non-ulcer dyspepsia // Aliment. Pharmacol. Ther. – 1995. – Vol. 9. – Suppl. 2. – P. 53–58.</mixed-citation><mixed-citation xml:lang="en">Buckley M., O′Morain C. Prevalence of Helicobacter pylori in non-ulcer dyspepsia // Aliment. Pharmacol. Ther. – 1995. – Vol. 9. – Suppl. 2. – P. 53–58.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Buonavolonta R., Goccorullo P., Boccia G. et al. Familial aggregation in children affected by functional gastrointestinal disorders // Gut. – 2008. – Vol. 57. – Suppl. II. – P. 3.</mixed-citation><mixed-citation xml:lang="en">Buonavolonta R., Goccorullo P., Boccia G. et al. Familial aggregation in children affected by functional gastrointestinal disorders // Gut. – 2008. – Vol. 57. – Suppl. II. – P. 3.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Caldarella M.P., Azpiroz F., Malagelada J.-R. Antro-fundic dysfunction in functional dyspepsia // Gastroenterology. – 2003. – Vol. 124. – P. 1202–1229.</mixed-citation><mixed-citation xml:lang="en">Caldarella M.P., Azpiroz F., Malagelada J.-R. Antro-fundic dysfunction in functional dyspepsia // Gastroenterology. – 2003. – Vol. 124. – P. 1202–1229.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Camilleri M., Hasler W.I., Parkman H.P. et al. Measurement of gastrointestinal motility in the GI laboratory // Gastroenterology. – 1998. – Vol. 115. – P. 747– 762.</mixed-citation><mixed-citation xml:lang="en">Camilleri M., Hasler W.I., Parkman H.P. et al. Measurement of gastrointestinal motility in the GI laboratory // Gastroenterology. – 1998. – Vol. 115. – P. 747– 762.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Correa P. Human gastric carcinogenesis: a multistep and multifactorial process – First American Cancer Society award lecture on gastric cancer epidemiology and prevention // Cancer Res. – 1992. – Vol. 52. – P. 7635–7640.</mixed-citation><mixed-citation xml:lang="en">Correa P. Human gastric carcinogenesis: a multistep and multifactorial process – First American Cancer Society award lecture on gastric cancer epidemiology and prevention // Cancer Res. – 1992. – Vol. 52. – P. 7635–7640.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Corsetti M., Tack J. Mechanisms of functional dyspepsia and its relation to IBS // Irritable bowel syndrome. Diagnosis and treatment / Eds. M. Camilleri, M.C. Spiller, W.B. Saunders. – London. – 2002. – P. 117– 126.</mixed-citation><mixed-citation xml:lang="en">Corsetti M., Tack J. Mechanisms of functional dyspepsia and its relation to IBS // Irritable bowel syndrome. Diagnosis and treatment / Eds. M. Camilleri, M.C. Spiller, W.B. Saunders. – London. – 2002. – P. 117– 126.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">El-Omar E., Penman I., Ardill J.E. et al. A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. – Gut. – 1995. – Vol. 36. – P. 534–538.</mixed-citation><mixed-citation xml:lang="en">El-Omar E., Penman I., Ardill J.E. et al. A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. – Gut. – 1995. – Vol. 36. – P. 534–538.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Feinle-Bisset C., Vozzo R., Horowitz M., Talley N.J. Diet, food intake and disturbed physiology in the pathogenesis of symptoms in functional dyspepsia // Am. J. Gastroenterol. – 2003. – Vol. 99. – P. 170–181.</mixed-citation><mixed-citation xml:lang="en">Feinle-Bisset C., Vozzo R., Horowitz M., Talley N.J. Diet, food intake and disturbed physiology in the pathogenesis of symptoms in functional dyspepsia // Am. J. Gastroenterol. – 2003. – Vol. 99. – P. 170–181.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ford F.C. Ching E., Moayyedi P. Meta-analysis of diagnostic tests for coeliac disease in dyspepsia // Aliment. Pharmacol. Ther. – 2009. – Vol. 30. – P. 28–36.</mixed-citation><mixed-citation xml:lang="en">Ford F.C. Ching E., Moayyedi P. Meta-analysis of diagnostic tests for coeliac disease in dyspepsia // Aliment. Pharmacol. Ther. – 2009. – Vol. 30. – P. 28–36.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Führer M., Vogelsang M., Hammer J. A double blind, placebo controlled study of the oral capsaicin test in patients with functional dyspepsia // Gut. – 2008. – Vol. 57. – Suppl. II. – P. 38.</mixed-citation><mixed-citation xml:lang="en">Führer M., Vogelsang M., Hammer J. A double blind, placebo controlled study of the oral capsaicin test in patients with functional dyspepsia // Gut. – 2008. – Vol. 57. – Suppl. II. – P. 38.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Holtmann G. Understanding functional dyspepsia &amp; its treatment with itopride // Medical Tribune. – 2006. – 1–15 Nov.</mixed-citation><mixed-citation xml:lang="en">Holtmann G. Understanding functional dyspepsia &amp; its treatment with itopride // Medical Tribune. – 2006. – 1–15 Nov.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Holtmann G., Talley N.J. Hypothesis driven research and molecular mechanisms in functional dyspepsia: the beginning of a beautiful cooperation in research and practice? // Am. J. Gastroenterol. – 2006. – Vol. 101. – P. 593– 595.</mixed-citation><mixed-citation xml:lang="en">Holtmann G., Talley N.J. Hypothesis driven research and molecular mechanisms in functional dyspepsia: the beginning of a beautiful cooperation in research and practice? // Am. J. Gastroenterol. – 2006. – Vol. 101. – P. 593– 595.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Holtmann G., Talley N.J. Clinician′s manual on managing dyspepsia. – Life Science Communications. – London, 2000. – 88 p.</mixed-citation><mixed-citation xml:lang="en">Holtmann G., Talley N.J. Clinician′s manual on managing dyspepsia. – Life Science Communications. – London, 2000. – 88 p.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Holtmann G., Talley N.J., T.Liebregts et al. A placebocontrolled trial of itopride in functional dyspepsia // N. Engl. J. Med. –2006. – Vol. 354. – P. 832–840.</mixed-citation><mixed-citation xml:lang="en">Holtmann G., Talley N.J., T.Liebregts et al. A placebocontrolled trial of itopride in functional dyspepsia // N. Engl. J. Med. –2006. – Vol. 354. – P. 832–840.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson J.L., O′Malley P.G., Tomkins G. et al. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis // Am. J. Med. – 2000. – Vol. 108. – P. 65–72.</mixed-citation><mixed-citation xml:lang="en">Jackson J.L., O′Malley P.G., Tomkins G. et al. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis // Am. J. Med. – 2000. – Vol. 108. – P. 65–72.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Jones M.P., Ebert Ch.C. Bloating and somatosensory amplification in functional dyspepsia (FD) // Am. J. Gastroenterol. – 2003. – Vol. 98. – P. 63–64.</mixed-citation><mixed-citation xml:lang="en">Jones M.P., Ebert Ch.C. Bloating and somatosensory amplification in functional dyspepsia (FD) // Am. J. Gastroenterol. – 2003. – Vol. 98. – P. 63–64.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kadota K., Takeshima F., Yoda A. et al. Effect of smoking cessation on gastric emptying in smokers // Gut. –2008. – Vol. 57. – Suppl. II. – P. 2.</mixed-citation><mixed-citation xml:lang="en">Kadota K., Takeshima F., Yoda A. et al. Effect of smoking cessation on gastric emptying in smokers // Gut. –2008. – Vol. 57. – Suppl. II. – P. 2.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kanath S. Comparative evaluation of the efficacy and tolerability of itopride and metaclopramide in patients with non-ulcer dyspepsia // JAMA-India. – 2003. – Vol. 2. – P. 95–98.</mixed-citation><mixed-citation xml:lang="en">Kanath S. Comparative evaluation of the efficacy and tolerability of itopride and metaclopramide in patients with non-ulcer dyspepsia // JAMA-India. – 2003. – Vol. 2. – P. 95–98.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Keohane J., Quigley E.M.M. Functional dyspepsia: The role of visceral hypersensitivity in its pathogenesis // World J. Gastoenterol. – 2006. – Vol. 12. – P. 2672–2676.</mixed-citation><mixed-citation xml:lang="en">Keohane J., Quigley E.M.M. Functional dyspepsia: The role of visceral hypersensitivity in its pathogenesis // World J. Gastoenterol. – 2006. – Vol. 12. – P. 2672–2676.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Knill-Jones R.P. Geographical differences in the prevalence of dyspepsia // Scand. J. Gastroenterol. – 1991– Vol. 26. – Suppl. 182. – P. 17–24.</mixed-citation><mixed-citation xml:lang="en">Knill-Jones R.P. Geographical differences in the prevalence of dyspepsia // Scand. J. Gastroenterol. – 1991– Vol. 26. – Suppl. 182. – P. 17–24.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Koloski N.A., Talleу N.J., Boyce Ph.M. Epidemiology and health care seeking in the functional GI disorders: a population-based study // Am. J. Gastroenterol. – 2002. – Vol. 97. – P. 2290–2299.</mixed-citation><mixed-citation xml:lang="en">Koloski N.A., Talleу N.J., Boyce Ph.M. Epidemiology and health care seeking in the functional GI disorders: a population-based study // Am. J. Gastroenterol. – 2002. – Vol. 97. – P. 2290–2299.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lapidus L., Andersson S., Bengtsson G., Kilander A. Prognosis of dyspepsia in women – a 24-year follow-up of a population sample // Gut. – 2002. – Vol. 34. – Suppl. II. – P. 106.</mixed-citation><mixed-citation xml:lang="en">Lapidus L., Andersson S., Bengtsson G., Kilander A. Prognosis of dyspepsia in women – a 24-year follow-up of a population sample // Gut. – 2002. – Vol. 34. – Suppl. II. – P. 106.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lin Z., Eaker E.Y., Sarosiek I., McCallum R. Gastric myoelectrical activity and gastric emptying in patients with functional dyspepsia // Am. J. Gastoenterol. – 1999. – Vol. 94. – P. 2384–2389.</mixed-citation><mixed-citation xml:lang="en">Lin Z., Eaker E.Y., Sarosiek I., McCallum R. Gastric myoelectrical activity and gastric emptying in patients with functional dyspepsia // Am. J. Gastoenterol. – 1999. – Vol. 94. – P. 2384–2389.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Locke G.R., Weaver A.L., Melton L.J., Talley N.J. Phsychological factors are linked to functional gastrointestinal disorders: a population based nasted case-control study. – Am. J. Gastroenterol. – 2004. – Vol. 99. – P. 350–357.</mixed-citation><mixed-citation xml:lang="en">Locke G.R., Weaver A.L., Melton L.J., Talley N.J. Phsychological factors are linked to functional gastrointestinal disorders: a population based nasted case-control study. – Am. J. Gastroenterol. – 2004. – Vol. 99. – P. 350–357.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">McQuaid K.R. Dyspepsia // Sleisenger and Fordtran′s gastrointestinal and liver disease / Ed. M. Feldman et al., 7th ed. – Philadelphia–London–Toronto–Montreal– Sydney–Tokyo, 2002. – P. 102–118.</mixed-citation><mixed-citation xml:lang="en">McQuaid K.R. Dyspepsia // Sleisenger and Fordtran′s gastrointestinal and liver disease / Ed. M. Feldman et al., 7th ed. – Philadelphia–London–Toronto–Montreal– Sydney–Tokyo, 2002. – P. 102–118.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Moayyedi P., Deeks J., Talley N.J. et al. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepance between systematic reviews // Am. J. Gastroenterol. – 2003. – Vol. 98. – P. 2621–2626.</mixed-citation><mixed-citation xml:lang="en">Moayyedi P., Deeks J., Talley N.J. et al. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepance between systematic reviews // Am. J. Gastroenterol. – 2003. – Vol. 98. – P. 2621–2626.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Moayyedi P., Delaney B.C., Vakil N. The efficacy of proton pump inhibitors in non-ulcer dyspepsia: a systematic review and economic analysis // Gastroenterology. – 2004. – Vol. 127. – P. 1329–1337.</mixed-citation><mixed-citation xml:lang="en">Moayyedi P., Delaney B.C., Vakil N. The efficacy of proton pump inhibitors in non-ulcer dyspepsia: a systematic review and economic analysis // Gastroenterology. – 2004. – Vol. 127. – P. 1329–1337.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Moayyedi P., Soo S., Deeks J. et al. Systemic review: Antacids, H2-receptor antagonists, prokinetiks, bismuth and sucralfate therapy for non-ulcer dyspepsia // Aliment. Pharmacol. Ther. – 2003. – Vol. 17. – P. 1215–1227.</mixed-citation><mixed-citation xml:lang="en">Moayyedi P., Soo S., Deeks J. et al. Systemic review: Antacids, H2-receptor antagonists, prokinetiks, bismuth and sucralfate therapy for non-ulcer dyspepsia // Aliment. Pharmacol. Ther. – 2003. – Vol. 17. – P. 1215–1227.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Mönkemüller K., Malfertheiner P. Drug treatment of functional dyspepsia // World J. Gastroenterol. – 2006. – Vol. 12. – P. 2694–2700.</mixed-citation><mixed-citation xml:lang="en">Mönkemüller K., Malfertheiner P. Drug treatment of functional dyspepsia // World J. Gastroenterol. – 2006. – Vol. 12. – P. 2694–2700.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Müller-Lissner S., Koelz H.R. Dyspepsiefibel. – Berlin– Heidelberg–New York. – 1991. – 67 s.</mixed-citation><mixed-citation xml:lang="en">Müller-Lissner S., Koelz H.R. Dyspepsiefibel. – Berlin– Heidelberg–New York. – 1991. – 67 s.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Nimmuan C., Rabe-Hesketh S., Wessely S., Hotopf M. How many functional somatic syndromes? // J. Phychosom. Res. – 2001. – Vol. 51. – P. 549–557.</mixed-citation><mixed-citation xml:lang="en">Nimmuan C., Rabe-Hesketh S., Wessely S., Hotopf M. How many functional somatic syndromes? // J. Phychosom. Res. – 2001. – Vol. 51. – P. 549–557.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Nyren O., Adami H.-O, Gustavsson S. et al. Social economic effects of non-ulcer dyspepsia // Scand. J. Gastroenterol. – 1985. – Vol. 20. – Suppl. 109. – P. 41–45.</mixed-citation><mixed-citation xml:lang="en">Nyren O., Adami H.-O, Gustavsson S. et al. Social economic effects of non-ulcer dyspepsia // Scand. J. Gastroenterol. – 1985. – Vol. 20. – Suppl. 109. – P. 41–45.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">O′Morain C. Indications for Helicobacter pylori infection erdication // Maastricht-3 Guidelines for Helicobacter pylori infection. – 13. United European Gastroenterology Week. – Copenhagen, 2005 (oral presentation).</mixed-citation><mixed-citation xml:lang="en">O′Morain C. Indications for Helicobacter pylori infection erdication // Maastricht-3 Guidelines for Helicobacter pylori infection. – 13. United European Gastroenterology Week. – Copenhagen, 2005 (oral presentation).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Peura D. Meeting expectations in FD: clinical and regulatory objectives. Clinician′s viewpoint // Functional dyspepsia: current evidence and cutting edge outcomes. – Abstract book. – Montreal, 2005. – P. 16–18.</mixed-citation><mixed-citation xml:lang="en">Peura D. Meeting expectations in FD: clinical and regulatory objectives. Clinician′s viewpoint // Functional dyspepsia: current evidence and cutting edge outcomes. – Abstract book. – Montreal, 2005. – P. 16–18.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Samson M., Verhagen M.A., van BergeHenegouwen G.P. et al. Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients // Gastroenterology. – 1999. – Vol. 116. – P. 515–520.</mixed-citation><mixed-citation xml:lang="en">Samson M., Verhagen M.A., van BergeHenegouwen G.P. et al. Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients // Gastroenterology. – 1999. – Vol. 116. – P. 515–520.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sarnelli G., Caenepeel Ph., Geypens B. et al. Symptoms associated with impared gastric emptying of solids and liquids in functional dyspepsia // Am. J. Gastroenterol. – 2003. – Vol. 98. – P. 783–788.</mixed-citation><mixed-citation xml:lang="en">Sarnelli G., Caenepeel Ph., Geypens B. et al. Symptoms associated with impared gastric emptying of solids and liquids in functional dyspepsia // Am. J. Gastroenterol. – 2003. – Vol. 98. – P. 783–788.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sarnelli G., De Giorgi F., Atteo E. et al. Frequency, symptom evolution and pathophysiological correlates in prospectively identified patients with postinfectious dyspepsia // DDW – New Orleans, 2010. – Abstract M2010.</mixed-citation><mixed-citation xml:lang="en">Sarnelli G., De Giorgi F., Atteo E. et al. Frequency, symptom evolution and pathophysiological correlates in prospectively identified patients with postinfectious dyspepsia // DDW – New Orleans, 2010. – Abstract M2010.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sawant P., Das H.S., Desai N. et al. Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non-ulcer dyspepsia // JAPI. – 2004. – Vol. 52. – P. 626–628.</mixed-citation><mixed-citation xml:lang="en">Sawant P., Das H.S., Desai N. et al. Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non-ulcer dyspepsia // JAPI. – 2004. – Vol. 52. – P. 626–628.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Soo Sh., Forman D., Delaney C., Moayyedi P. A systemic review of psychological therapies for nonulcer duspepsia // Am. J. Gastroenterol. – 2004. – Vol. 99. – P. 1817–1822.</mixed-citation><mixed-citation xml:lang="en">Soo Sh., Forman D., Delaney C., Moayyedi P. A systemic review of psychological therapies for nonulcer duspepsia // Am. J. Gastroenterol. – 2004. – Vol. 99. – P. 1817–1822.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Stanghellini V., Tosetti C., Paternico A. et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia // Gastroenterology. – 1996. – Vol. 110. – P. 1036–1042.</mixed-citation><mixed-citation xml:lang="en">Stanghellini V., Tosetti C., Paternico A. et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia // Gastroenterology. – 1996. – Vol. 110. – P. 1036–1042.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J. New therapeutic targets for FD: what, how and whom? // Functional dyspepsia: current evidence and cutting edge outcomes . – Abstract book. – Montreal, 2005. – P. 22–24.</mixed-citation><mixed-citation xml:lang="en">Tack J. New therapeutic targets for FD: what, how and whom? // Functional dyspepsia: current evidence and cutting edge outcomes . – Abstract book. – Montreal, 2005. – P. 22–24.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Caenepeel P., Fischler B. et al. Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia // Gastroenterology. – 2001. – Vol. 121. – P. 526–535</mixed-citation><mixed-citation xml:lang="en">Tack J., Caenepeel P., Fischler B. et al. Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia // Gastroenterology. – 2001. – Vol. 121. – P. 526–535</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Piessevaux H., Coulie B. et al. Role of impaired gastric accommodation to a meal in functional dyspepsia // Gastroenterology. – 1998. – Vol. 115. – P. 1346– 1352.</mixed-citation><mixed-citation xml:lang="en">Tack J., Piessevaux H., Coulie B. et al. Role of impaired gastric accommodation to a meal in functional dyspepsia // Gastroenterology. – 1998. – Vol. 115. – P. 1346– 1352.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Talley N.J., Camilleri M. et al. Functional gastroduodenal disorders // Gastroenterology. – 2006.– Vol. 130. – P. 1466–1479.</mixed-citation><mixed-citation xml:lang="en">Tack J., Talley N.J., Camilleri M. et al. Functional gastroduodenal disorders // Gastroenterology. – 2006.– Vol. 130. – P. 1466–1479.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Talley N.J. and the working team for functional gastroduodenal disorders. Functional gastroduodenal disorders // The functional gastrointestinal disorders. – Boston – New York–Toronto–London, 1994. – P. 71–113.</mixed-citation><mixed-citation xml:lang="en">Talley N.J. and the working team for functional gastroduodenal disorders. Functional gastroduodenal disorders // The functional gastrointestinal disorders. – Boston – New York–Toronto–London, 1994. – P. 71–113.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Talley N.J., Helgeson S.L., Zinsmeister A.R. et al. Gastrointestinal tract symptoms and self-reported abuse: a population-based-study // Gastroenterology. – 1994. – Vol. 107. – P. 1040–1049.</mixed-citation><mixed-citation xml:lang="en">Talley N.J., Helgeson S.L., Zinsmeister A.R. et al. Gastrointestinal tract symptoms and self-reported abuse: a population-based-study // Gastroenterology. – 1994. – Vol. 107. – P. 1040–1049.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Talley N.J., Janssens L., Lauritsen K. et al. Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 month follow up // Br. Med. J. – 1999. – Vol. 318. – P. 833–837.</mixed-citation><mixed-citation xml:lang="en">Talley N.J., Janssens L., Lauritsen K. et al. Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 month follow up // Br. Med. J. – 1999. – Vol. 318. – P. 833–837.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Talley N.J., Meineche-Schmidt V., Pare P. et al. Eficacy of omeprazole im functional dyspepsia: doubleblind, randomized, placebo-controlled trials (the Bond and Opera studies) // Aliment. Pharnacol. Ther. – 1998. – Vol. 12. – P. 1055–1065.</mixed-citation><mixed-citation xml:lang="en">Talley N.J., Meineche-Schmidt V., Pare P. et al. Eficacy of omeprazole im functional dyspepsia: doubleblind, randomized, placebo-controlled trials (the Bond and Opera studies) // Aliment. Pharnacol. Ther. – 1998. – Vol. 12. – P. 1055–1065.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Talley N.J., Stanghellini V., Heading R.C. et al. Functional gastroduodenal disorders // Rome II. The Functional Gastrointestinal Disorders / Ed. D.A. Drossman, 2th Ed. – Allen Press. – 2000. – P. 299–350.</mixed-citation><mixed-citation xml:lang="en">Talley N.J., Stanghellini V., Heading R.C. et al. Functional gastroduodenal disorders // Rome II. The Functional Gastrointestinal Disorders / Ed. D.A. Drossman, 2th Ed. – Allen Press. – 2000. – P. 299–350.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Tominaga K., Suzuki H., Umegaki E. et al. Rabeprazole imprоves the symptoms of functional dyspepsia – a double-blind randomized placebo-controlled multi-center trial in Japan: The CAESAR study // DDW – New Orleans, 2010. – Abstract 383.</mixed-citation><mixed-citation xml:lang="en">Tominaga K., Suzuki H., Umegaki E. et al. Rabeprazole imprоves the symptoms of functional dyspepsia – a double-blind randomized placebo-controlled multi-center trial in Japan: The CAESAR study // DDW – New Orleans, 2010. – Abstract 383.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Van Lelyveld N., Scheffer R., Mundt M., Samson M. Partial gastric volumes and upper abdominal sensations in functional dyspeptic and GERD patients: a 3D ultrasonographic study // Am. J. Gastroenterol. – 2006. – Vol. 101. – P. 1845–1852.</mixed-citation><mixed-citation xml:lang="en">Van Lelyveld N., Scheffer R., Mundt M., Samson M. Partial gastric volumes and upper abdominal sensations in functional dyspeptic and GERD patients: a 3D ultrasonographic study // Am. J. Gastroenterol. – 2006. – Vol. 101. – P. 1845–1852.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Warrwewijk C.J., van Oijen M.G.H., Paloheimo L.I. et al. Influence of gastric mucosal status on successs of stepwise acid suppressive therapy for dyspepsia // Aliment. Pharmacol. Ther. – 2009. – Vol. 30. – P. 82–89.</mixed-citation><mixed-citation xml:lang="en">Warrwewijk C.J., van Oijen M.G.H., Paloheimo L.I. et al. Influence of gastric mucosal status on successs of stepwise acid suppressive therapy for dyspepsia // Aliment. Pharmacol. Ther. – 2009. – Vol. 30. – P. 82–89.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Wilhelmsen I., Haug T., Sipponen P., Berstad A. Helicobacter pylori in functional dyspepsia // Scand. J. Gastroenterol. – 1994. – Vol. 29. – P. 522–527.</mixed-citation><mixed-citation xml:lang="en">Wilhelmsen I., Haug T., Sipponen P., Berstad A. Helicobacter pylori in functional dyspepsia // Scand. J. Gastroenterol. – 1994. – Vol. 29. – P. 522–527.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
