gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1337Research ArticleНОВОСТИ КОЛОПРОКТОЛОГИИNEWS OF COLOPROCTOLOGYСемейный аденоматоз толстой кишки: хирургическое лечение с применением клеточной трансплантацииFamilial adenomatosis coli: surgical treatment with cellular transplantationШелыгинЮ. А.ShelyginYu. A.КузьминовА. М.KuzminovA. M.ВышегородцевД. В.VyshegorodtsevD. V.КапуллерЛ. Л.KapullerL. L.СухихГ. Т.SukhikhG. T.2012011120122265358Copyright © Шелыгин Ю.А., Кузьминов А.М., Вышегородцев Д.В., Капуллер Л.Л., Сухих Г.Т., 20122012Шелыгин Ю.А., Кузьминов А.М., Вышегородцев Д.В., Капуллер Л.Л., Сухих Г.Т.Shelygin Y.A., Kuzminov A.M., Vyshegorodtsev D.V., Kapuller L.L., Sukhikh G.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1337

Цель исследования. Создание реконструированной слизистой оболочки прямой кишки с целью улучшения результатов хирургического лечения семейного аденоматоза толстой кишки (САТК).Материал и методы. 27 больным САТК проведено хирургическое лечение, включающее колэктомию, демукозацию прямой кишки и аллогенную клеточную трансплантацию фетальными клетками кишечного эпителия и мезенхимы различного происхождения с целью создания реконструированной слизистой оболочки. У 5 больных сформирован илеоректальный анастомоз, у 22 – тонкокишечные резервуары.Результаты. За период от 4 до 12 нед у всех пациентов отмечено формирование слизистой оболочки в прямой кишке. При наблюдении от 1 года до 5 лет роста полипов не выявлено у 26 (96,3%) пациентов.Выводы. Для создания реконструированной слизистой оболочки прямой кишки может успешно применяться клеточная трансплантация. Сохранение части прямой кишки после колэктомии и формирование тонкокишечного резервуара позволяет сохранить естественный кишечный пассаж с хорошими функциональными результатами.

Aim of investigation

Aim of investigation. To develop reconstructed mucosa of the rectum for improvement results of surgical treatment of familial adenomatosis polyposis coli (FAP).

Material and methods

Material and methods. Overall 27 patients with FAP underwent surgical treatment including colectomy, demucosation of rectum and allogenic transplantation of fetal intestinal epithelium cells and mesenchyma of various origin to develop reconstructed mucosa. In 5 patients the ileorectal anastomosis, in 22 – small-intestinal reservoirs were created.

Results

Results. During period from 4 to 12 wks development of rectal mucosa was observed in all patients. At follow-up from 1 year to 5 years no proliferation of polyps was revealed in 26 (96,3%) patients.

Conclusions

Conclusions. Cell transplantation can successfully be applied for development of reconstructed rectal mucosa. Keeping part of rectum after colectomy and formation of smallintestinal reservoir allows to keep natural intestinal passage with good functional results.

семейный аденоматоз толстой кишкиклеточная трансплантациямезенхимакишечный эпителийfamilial adenomatosis polyposis colicell transplantationmesenchymaintestinal epitheliumReferencesВоробьев Г.И. Основы колопроктологии: Учебное пособие. – Ростов н/Д: «Феникс», 2001. – С. 320–332.Воробьев Г.И. Основы колопроктологии: Учебное пособие. – Ростов н/Д: «Феникс», 2001. – С. 320–332.Barton J.G., Paden M.A., Lane M., Postier R.G. Comparison of postoperative outcomes in ulcerative colitis and familial polyposis patients after ileoanal pouch operations // Am. J. Surg. – 2001. – Vol. 182. – P. 616–620.Barton J.G., Paden M.A., Lane M., Postier R.G. Comparison of postoperative outcomes in ulcerative colitis and familial polyposis patients after ileoanal pouch operations // Am. J. Surg. – 2001. – Vol. 182. – P. 616–620.Behrends J., Jerchow B.A., Wurtele M. et al. Functional interaction of an axon homolog, conductin, with b-catenin, APC, and GSK3 // Science. – 1998. – Vol. 280. – P. 596–599.Behrends J., Jerchow B.A., Wurtele M. et al. Functional interaction of an axon homolog, conductin, with b-catenin, APC, and GSK3 // Science. – 1998. – Vol. 280. – P. 596–599.Bulow S. Familial polyposis // Dan. Med. Bull. – 1987. – Vol. 34. – P. 1–15.Bulow S. Familial polyposis // Dan. Med. Bull. – 1987. – Vol. 34. – P. 1–15.Bussey H.J.R., Eyers A.A., Ritchie S.M., Thomson J.P.S. The rectum in adenomatous polyposis: The St-Mark`s policy // Br. J. Surg. – 1985. – Vol. 72 (suppl.). – P. 29–31.Bussey H.J.R., Eyers A.A., Ritchie S.M., Thomson J.P.S. The rectum in adenomatous polyposis: The St-Mark`s policy // Br. J. Surg. – 1985. – Vol. 72 (suppl.). – P. 29–31.Campos F.G., Perez R.O., Imperiale A.R. et. al. Surgical treatment of familial adenomatous polyposis: ileorectal anastomosis or restorative proctocolectomy? // Arq. Gastroenterol. – Vol. 46, N 4. – P. 294–299.Campos F.G., Perez R.O., Imperiale A.R. et. al. Surgical treatment of familial adenomatous polyposis: ileorectal anastomosis or restorative proctocolectomy? // Arq. Gastroenterol. – Vol. 46, N 4. – P. 294–299.Choi R.S., Reiqler M., Pothoulakis C. et al. Studies of brush border enzymes, basement membrane components, and electrophysiology of tissue-engineered neointestine // J. Pediatr. Surg. – 1998. – Vol. 33. – P. 991–997.Choi R.S., Reiqler M., Pothoulakis C. et al. Studies of brush border enzymes, basement membrane components, and electrophysiology of tissue-engineered neointestine // J. Pediatr. Surg. – 1998. – Vol. 33. – P. 991–997.Grikscheit T.C. et al. Tissue-engineered colon exhibits function in vivo // Surgery. – 2002. – Vol. 32. – P. 200–204.Grikscheit T.C. et al. Tissue-engineered colon exhibits function in vivo // Surgery. – 2002. – Vol. 32. – P. 200–204.Grikscheit T.C., Vacanti J.P. Tissue-engineered stomach from autologous and syngeneic tissue // J. Surg. Res. – 2002. – Vol. 107. – P. 277–288.Grikscheit T.C., Vacanti J.P. Tissue-engineered stomach from autologous and syngeneic tissue // J. Surg. Res. – 2002. – Vol. 107. – P. 277–288.Groden J., Thliveris A., Samowitz W. et al. Identification and characterization of the familial adenomatous polyposis coli gene // Cell. – 1991. – Vol. 66. – P. 589–600.Groden J., Thliveris A., Samowitz W. et al. Identification and characterization of the familial adenomatous polyposis coli gene // Cell. – 1991. – Vol. 66. – P. 589–600.Kaihara S. et al. Long-term follow-up of tissue-engineered intestine after anastomosis to native small bowel // Transplantation. – 2000. – Vol. 69. – P. 1927–1932.Kaihara S. et al. Long-term follow-up of tissue-engineered intestine after anastomosis to native small bowel // Transplantation. – 2000. – Vol. 69. – P. 1927–1932.Kasraoui M., Cohen R., Nicholls J. Results of surgical of the pouch after failed restorative proctocolectomy // Dis. Colon. Rectum. – 2004. – Vol. 47. – P. 869–675.Kasraoui M., Cohen R., Nicholls J. Results of surgical of the pouch after failed restorative proctocolectomy // Dis. Colon. Rectum. – 2004. – Vol. 47. – P. 869–675.Kinzler K.W., Nilbert M.C., Su L.K. et al. Identification of FAP locus genes from chromosome 5q21 // Science. – 1991. – Vol. 253. – P. 661–665.Kinzler K.W., Nilbert M.C., Su L.K. et al. Identification of FAP locus genes from chromosome 5q21 // Science. – 1991. – Vol. 253. – P. 661–665.Miyoshi Y., Ando H., Nagase H. et al. Germline mutations of the APC gene in 53 familial adenomatous polyposis patients // Proc. Natl. Acad. Sci. USA. – 1992. – Vol. 89. – P. 4452–4456.Miyoshi Y., Ando H., Nagase H. et al. Germline mutations of the APC gene in 53 familial adenomatous polyposis patients // Proc. Natl. Acad. Sci. USA. – 1992. – Vol. 89. – P. 4452–4456.Nishisho I., Nakamura Y., Miyoshi Y. et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients // Science. – 1991. – Vol. 253. – P. 665–669.Nishisho I., Nakamura Y., Miyoshi Y. et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients // Science. – 1991. – Vol. 253. – P. 665–669.Oded Zmora, Jonathan E. Efron, Juan J. Nogueras et al. Reoperative abdominal and perineal surgery in ileoanal pouch patients // Dis. Colon Rectum. – 2001. – Vol. 44, N 9. – P. 1310–1314.Oded Zmora, Jonathan E. Efron, Juan J. Nogueras et al. Reoperative abdominal and perineal surgery in ileoanal pouch patients // Dis. Colon Rectum. – 2001. – Vol. 44, N 9. – P. 1310–1314.Pars Y.R., Olschwang S., Desaint B. et al. Familial adenomatous: prevalence of adenomas in the ileal pouch after restorative proctocolectomy // Ann. Surg. – 2001. – Vol. 233. – P. 360–364.Pars Y.R., Olschwang S., Desaint B. et al. Familial adenomatous: prevalence of adenomas in the ileal pouch after restorative proctocolectomy // Ann. Surg. – 2001. – Vol. 233. – P. 360–364.Soravia C., Cohen Z. Familial adenomatous polyposis // Current therapy in colon and rectum surgery / Eds. Fazio V.N., Church J.M., Delaney C.P. – 2nd ed. – Philadelphia: Elsevier-Mosby, 2004. – P. 349–353.Soravia C., Cohen Z. Familial adenomatous polyposis // Current therapy in colon and rectum surgery / Eds. Fazio V.N., Church J.M., Delaney C.P. – 2nd ed. – Philadelphia: Elsevier-Mosby, 2004. – P. 349–353.Tavakkolizaden A. et al. Tissue-engineered neomucosa: morphology, enterocyte dynamics, and SGLT – 1 expression topography // Transplantation. – 2003. – Vol. 75. – P. 181–185.Tavakkolizaden A. et al. Tissue-engineered neomucosa: morphology, enterocyte dynamics, and SGLT – 1 expression topography // Transplantation. – 2003. – Vol. 75. – P. 181–185.Thompson-Fawcett M.W., Marcus V.A., Redston M. et al. Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous poliposis // Dis. Colon Rectum. – 2001. – Vol. 44, N 3. – P. 347–353.Thompson-Fawcett M.W., Marcus V.A., Redston M. et al. Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous poliposis // Dis. Colon Rectum. – 2001. – Vol. 44, N 3. – P. 347–353.Varesco L., Gismondi V., James R. et al. Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis // Am. J. Hum. Genet. – 1993. – Vol. 52. – P. 280–285.Varesco L., Gismondi V., James R. et al. Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis // Am. J. Hum. Genet. – 1993. – Vol. 52. – P. 280–285.White R.L. Tumor suppressing pathways // Cell. – 1998. – Vol. 92. – P. 591–592.White R.L. Tumor suppressing pathways // Cell. – 1998. – Vol. 92. – P. 591–592.

The authors declare that there are no conflicts of interest present.