<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1369</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВОСТИ КОЛОПРОКТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEWS OF COLOPROCTOLOGY</subject></subj-group></article-categories><title-group><article-title>Мультидисциплинарный подход в периоперационном ведении больных колоректальным раком в старческом возрасте</article-title><trans-title-group xml:lang="en"><trans-title>The multidisciplinary approach in perioperative management of senile patients with colorectal cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маркарьян</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Markar'yan</surname><given-names>D. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никода</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikoda</surname><given-names>V. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Царьков</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsarkov</surname><given-names>P. V.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>21</day><month>02</month><year>2011</year></pub-date><volume>21</volume><issue>1</issue><fpage>50</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маркарьян Д.Р., Никода В.В., Царьков П.В., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Маркарьян Д.Р., Никода В.В., Царьков П.В.</copyright-holder><copyright-holder xml:lang="en">Markar'yan D.V., Nikoda V.V., Tsarkov P.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1369">https://www.gastro-j.ru/jour/article/view/1369</self-uri><abstract><p>Цель обзора. Предоставить данные о хирургическом лечении больных колоректальным раком старческого возраста, оценить основные причины неудовлетворительных результатов.Основные положения. Согласно данным литературы, сегодня уровень помощи гериатрическим больным колоректальным раком недостаточен во всем мире, в том числе и в России. В последние десятилетия научное сообщество единогласно во мнении, что результаты хирургического лечения рака прямой и ободочной кишки при тщательной периоперационной оценке и трансдисциплинарной подготовке не зависят от возраста больных.Заключение. Мультидисциплинарный подход в подготовке и периоперационном ведении пациентов старческого возраста, страдающих колоректальным раком, позволяет выполнить радикальное хирургическое вмешательство без увеличения летальности, что приводит к снижению процента экстренных операций и тем самым улучшает выживаемость. Если больной при мультидисциплинарной оценке периоперационного риска признан операбельным, стандартная хирургическая тактика с соблюдением онкологических принципов может выполняться без значительного повышения риска хирургических осложнений.</p></abstract><trans-abstract xml:lang="en"><sec><title>The aim of review</title><p>The aim of review. To present data on surgical treatment of patients of senile age with colorectal cancer, to estimate principal causes of unsatisfactory results.</p></sec><sec><title>Original positions</title><p>Original positions. According to literature data, the present level of medical care for geriatric patients with colorectal cancer is insufficient all over the world, including in Russia. In last decades scientific community was unanimous in opinion, that results of surgical treatment of cancer of the rectum and colon at careful perioperative evaluation and transdisciplinary preparation do not depend on patients’ age.</p></sec><sec><title>Conclusion</title><p>Conclusion. Multidisciplinary approach in preparation and perioperative management of senile patient with colorectal cancer, allows to carry out radical surgical treatment without increase of mortality that results in decrease of urgent surgery rate and therefore improves survival rate. If patient at multidisciplinary evaluation of perioperative risk is recognized as resectable, standard surgical approach based on oncologic principles can be carried out without substantial increase of risk of surgical complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>колоректальный рак</kwd><kwd>старческий возраст</kwd><kwd>мультидисциплинарный подход</kwd><kwd>радикальное оперативное вмешательство</kwd></kwd-group><kwd-group xml:lang="en"><kwd>colorectal cancer</kwd><kwd>senile age</kwd><kwd>multidisciplinary approach</kwd><kwd>radical surgical intervention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Атуи А.А. Хирургическая тактика при осложненном колоректальном раке у больных пожилого возраста. // Автореферат дис. ... канд. мед. наук. – Ростов-н/Д., 2001.</mixed-citation><mixed-citation xml:lang="en">Атуи А.А. Хирургическая тактика при осложненном колоректальном раке у больных пожилого возраста. // Автореферат дис. ... канд. мед. наук. – Ростов-н/Д., 2001.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Барсуков Ю.А., Кныш В.И. Современные возможности лечения колоректального рака // Современная онкология. – 2006. – Т. 8, № 2. – С. 7–16.</mixed-citation><mixed-citation xml:lang="en">Барсуков Ю.А., Кныш В.И. Современные возможности лечения колоректального рака // Современная онкология. – 2006. – Т. 8, № 2. – С. 7–16.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев В.В. Клиническая оценка сфинктерсохраняющих операций при раке прямой кишки у больных пожилого возраста. //Автореферат дис. ... канд. мед. наук. – Ростов-на-Дону. – 2000.</mixed-citation><mixed-citation xml:lang="en">Воробьев В.В. Клиническая оценка сфинктерсохраняющих операций при раке прямой кишки у больных пожилого возраста. //Автореферат дис. ... канд. мед. наук. – Ростов-на-Дону. – 2000.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев Г.И. Непосредственные результаты передней резекции прямой кишки по поводу рака у лиц пожилого и старческого возраста (история вопроса и собственные данные) // Клин. геронтология. – 2002. – Т. 8, № 12.– С. 13–18.</mixed-citation><mixed-citation xml:lang="en">Воробьев Г.И. Непосредственные результаты передней резекции прямой кишки по поводу рака у лиц пожилого и старческого возраста (история вопроса и собственные данные) // Клин. геронтология. – 2002. – Т. 8, № 12.– С. 13–18.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2004 г. // Вестн. Рос. онкол. науч. центра им. Н.Н. Блохина РАМН. – 2006. – Т. 17, № 3.</mixed-citation><mixed-citation xml:lang="en">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2004 г. // Вестн. Рос. онкол. науч. центра им. Н.Н. Блохина РАМН. – 2006. – Т. 17, № 3.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2007 г. // Вестн. Рос. онкол. науч. центра им. Н.Н. Блохина РАМН. – 2009. – Т. 20, № 3 (прил. 1).</mixed-citation><mixed-citation xml:lang="en">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2007 г. // Вестн. Рос. онкол. науч. центра им. Н.Н. Блохина РАМН. – 2009. – Т. 20, № 3 (прил. 1).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дмитриев М.О. Хирургическое лечение осложненного колоректального рака у лиц пожилого и старческого возраста. // Автореф. дис. ... канд. мед. наук. – Владивосток. – 2007.</mixed-citation><mixed-citation xml:lang="en">Дмитриев М.О. Хирургическое лечение осложненного колоректального рака у лиц пожилого и старческого возраста. // Автореф. дис. ... канд. мед. наук. – Владивосток. – 2007.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Карпенко В.В. Возможности хирургического метода в медицинской реабилитации пожилых больных при осложненном раке толстой кишки. // Автореф. дис. ... канд. мед. наук. – Ростов-н/Д. – 2007.</mixed-citation><mixed-citation xml:lang="en">Карпенко В.В. Возможности хирургического метода в медицинской реабилитации пожилых больных при осложненном раке толстой кишки. // Автореф. дис. ... канд. мед. наук. – Ростов-н/Д. – 2007.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Мартынюк В.В. Пути улучшения результатов хирургического лечения рака прямой кишки у больных пожилого и старческого возраста // Избранные вопросы онкологии. – 1999. – С. 299–301.</mixed-citation><mixed-citation xml:lang="en">Мартынюк В.В. Пути улучшения результатов хирургического лечения рака прямой кишки у больных пожилого и старческого возраста // Избранные вопросы онкологии. – 1999. – С. 299–301.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Пузин В.Н. Особенности хирургического лечения осложненных форм колоректального рака у пациентов пожилого и старческого возраста // Мед. помощь. – 2006. – № 6. – С. 24–26.</mixed-citation><mixed-citation xml:lang="en">Пузин В.Н. Особенности хирургического лечения осложненных форм колоректального рака у пациентов пожилого и старческого возраста // Мед. помощь. – 2006. – № 6. – С. 24–26.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Сулейман Т.А. Хирургическое лечение рака прямой кишки у больных пожилого и старческого возраста. // Автореф дис. ... канд. мед. наук. – Спб. – 2000.</mixed-citation><mixed-citation xml:lang="en">Сулейман Т.А. Хирургическое лечение рака прямой кишки у больных пожилого и старческого возраста. // Автореф дис. ... канд. мед. наук. – Спб. – 2000.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Царюк В.Ф. Возможности хирургического лечения рака прямой кишки у лиц пожилого возраста // Медицинские проблемы пожилых. – 1999.</mixed-citation><mixed-citation xml:lang="en">Царюк В.Ф. Возможности хирургического лечения рака прямой кишки у лиц пожилого возраста // Медицинские проблемы пожилых. – 1999.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Audisio R.A. et al. Preoperative assessment of surgical risk in oncogeriatric patients // Oncologist. – 2005. – Vol. 10, N 4. – P. 262–268.</mixed-citation><mixed-citation xml:lang="en">Audisio R.A. et al. Preoperative assessment of surgical risk in oncogeriatric patients // Oncologist. – 2005. – Vol. 10, N 4. – P. 262–268.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Audisio R.A. et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study // Crit. Rev. Oncol. Hematol. – 2008. – Vol. 65, N 2. – P. 156–163.</mixed-citation><mixed-citation xml:lang="en">Audisio R.A. et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study // Crit. Rev. Oncol. Hematol. – 2008. – Vol. 65, N 2. – P. 156–163.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Audisio R.A. et al. The surgical management of elderly cancer patients; recommendations of the SIOG surgical task force // Eur. J. Cancer. – 2004. – Vol. 40, N 7. – P. 926–938.</mixed-citation><mixed-citation xml:lang="en">Audisio R.A. et al. The surgical management of elderly cancer patients; recommendations of the SIOG surgical task force // Eur. J. Cancer. – 2004. – Vol. 40, N 7. – P. 926–938.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Basili G. et al. Colorectal cancer in the elderly. Is there a role for safe and curative surgery? // ANZ J. Surg. – 2008. – Vol. 78, N 6. – P. 466–470.</mixed-citation><mixed-citation xml:lang="en">Basili G. et al. Colorectal cancer in the elderly. Is there a role for safe and curative surgery? // ANZ J. Surg. – 2008. – Vol. 78, N 6. – P. 466–470.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Christensen K. et al. Ageing populations: the challenges ahead // Lancet. – 2009. – Vol. 374 (9696). – P. 1196–1208.</mixed-citation><mixed-citation xml:lang="en">Christensen K. et al. Ageing populations: the challenges ahead // Lancet. – 2009. – Vol. 374 (9696). – P. 1196–1208.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Diggs J.C. et al. Failure to screen: predictors and burden of emergency colorectal cancer resection // Am. J. Manag. Care. – 2007. – Vol. 13, N 3. – P. 157–164.</mixed-citation><mixed-citation xml:lang="en">Diggs J.C. et al. Failure to screen: predictors and burden of emergency colorectal cancer resection // Am. J. Manag. Care. – 2007. – Vol. 13, N 3. – P. 157–164.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ellis G., Langhorne P. Comprehensive geriatric assessment for older hospital patients // Br. Med. Bull. – 2004. – Vol. 71. – P. 45–59.</mixed-citation><mixed-citation xml:lang="en">Ellis G., Langhorne P. Comprehensive geriatric assessment for older hospital patients // Br. Med. Bull. – 2004. – Vol. 71. – P. 45–59.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Faivre J. et al. Management and survival of colorectal cancer in the elderly in population-based studies // Eur. J. Cancer. – 2007. – Vol. 43, N 15. – P. 2279–2284.</mixed-citation><mixed-citation xml:lang="en">Faivre J. et al. Management and survival of colorectal cancer in the elderly in population-based studies // Eur. J. Cancer. – 2007. – Vol. 43, N 15. – P. 2279–2284.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Fried L.P. et al. Association of comorbidity with disability in older women: the Women’s Health and Aging Study // J. Clin. Epidemiol. – 1999. – Vol. 52, N 1. – P. 27–37.</mixed-citation><mixed-citation xml:lang="en">Fried L.P. et al. Association of comorbidity with disability in older women: the Women’s Health and Aging Study // J. Clin. Epidemiol. – 1999. – Vol. 52, N 1. – P. 27–37.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Golfinopoulos V., Pentheroudakis G., Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature // Cancer Treat. Rev. – 2006. – Vol. 32, N 1. – P. 1–8.</mixed-citation><mixed-citation xml:lang="en">Golfinopoulos V., Pentheroudakis G., Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature // Cancer Treat. Rev. – 2006. – Vol. 32, N 1. – P. 1–8.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gosney M. Letter to the Editor. Age Ageing, 2006.</mixed-citation><mixed-citation xml:lang="en">Gosney M. Letter to the Editor. Age Ageing, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Helwick C. Information for patients. HER2+ early breast cancer: understanding adjuvant treatment // Oncology (Williston Park). – 2009. – Vol. 23 (11 Suppl Nurse Ed.). – P. 8a–8b.</mixed-citation><mixed-citation xml:lang="en">Helwick C. Information for patients. HER2+ early breast cancer: understanding adjuvant treatment // Oncology (Williston Park). – 2009. – Vol. 23 (11 Suppl Nurse Ed.). – P. 8a–8b.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Isbister W.H., Al-Sanea N. POSSUM: a re-evaluation in patients undergoing surgery for rectal cancer. The Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity // ANZ J. Surg. – 2002. – Vol. 72, N 6. – P. 421–425.</mixed-citation><mixed-citation xml:lang="en">Isbister W.H., Al-Sanea N. POSSUM: a re-evaluation in patients undergoing surgery for rectal cancer. The Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity // ANZ J. Surg. – 2002. – Vol. 72, N 6. – P. 421–425.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jones H.J., de Cossart L. Risk scoring in surgical patients // Br. J. Surg. – 1999. – Vol. 86, N 2. – P. 149–157.</mixed-citation><mixed-citation xml:lang="en">Jones H.J., de Cossart L. Risk scoring in surgical patients // Br. J. Surg. – 1999. – Vol. 86, N 2. – P. 149–157.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Jones H.J. et al. Value of a surgical high-dependency unit // Br. J. Surg. – 1999. – Vol. 86, N 12. – P. 1578–1582.</mixed-citation><mixed-citation xml:lang="en">Jones H.J. et al. Value of a surgical high-dependency unit // Br. J. Surg. – 1999. – Vol. 86, N 12. – P. 1578–1582.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Latkauskas T. et al. The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment // BMC Cancer. – 2005. – Vol. 5. – P. 153.</mixed-citation><mixed-citation xml:lang="en">Latkauskas T. et al. The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment // BMC Cancer. – 2005. – Vol. 5. – P. 153.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Li S. et al. Screening and early diagnosis of colorectal cancer in China: a 12 year retrospect (1994-2006) // J. Cancer Res. Clin. Oncol. – 2007. – Vol. 133, N 10. – P. 679–686.</mixed-citation><mixed-citation xml:lang="en">Li S. et al. Screening and early diagnosis of colorectal cancer in China: a 12 year retrospect (1994-2006) // J. Cancer Res. Clin. Oncol. – 2007. – Vol. 133, N 10. – P. 679–686.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Manfredi S. et al. Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population // Br. J. Surg. – 2006. – Vol. 93, N 9. – P. 1115–1122.</mixed-citation><mixed-citation xml:lang="en">Manfredi S. et al. Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population // Br. J. Surg. – 2006. – Vol. 93, N 9. – P. 1115–1122.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Marik P.E. Management of the critically ill geriatric patient // Crit. Care Med. – 2006. – Vol. 34, N 9 (suppl.). – P. 176–182.</mixed-citation><mixed-citation xml:lang="en">Marik P.E. Management of the critically ill geriatric patient // Crit. Care Med. – 2006. – Vol. 34, N 9 (suppl.). – P. 176–182.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Martin-Martorell P. et al. Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy: results of a phase II single institution trial // Br. J. Cancer. – 2008. – Vol. 99, N 3. – P. 455–458.</mixed-citation><mixed-citation xml:lang="en">Martin-Martorell P. et al. Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy: results of a phase II single institution trial // Br. J. Cancer. – 2008. – Vol. 99, N 3. – P. 455–458.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mastracci T.M. et al. The impact of surgery for colorectal cancer on quality of life and functional status in the elderly // Dis. Colon Rectum. – 2006. – Vol. 49, N 12. – P. 1878–1884.</mixed-citation><mixed-citation xml:lang="en">Mastracci T.M. et al. The impact of surgery for colorectal cancer on quality of life and functional status in the elderly // Dis. Colon Rectum. – 2006. – Vol. 49, N 12. – P. 1878–1884.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mathias J.M. Scoring fire risk for surgical patients // OR Manager. – 2006. – Vol. 22, N 1. – P. 19–20.</mixed-citation><mixed-citation xml:lang="en">Mathias J.M. Scoring fire risk for surgical patients // OR Manager. – 2006. – Vol. 22, N 1. – P. 19–20.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Monfardini S. et al. Vulnerable and frail elderly: an approach to the management of the main tumour types // Eur. J. Cancer. – 2008. – Vol. 44, N 4. – P. 488–493.</mixed-citation><mixed-citation xml:lang="en">Monfardini S. et al. Vulnerable and frail elderly: an approach to the management of the main tumour types // Eur. J. Cancer. – 2008. – Vol. 44, N 4. – P. 488–493.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mongan J. et al Management of colorectal cancer in the еlderly // Clin. Geriatrics. – 2010. – Vol. 18 (Issue 1).</mixed-citation><mixed-citation xml:lang="en">Mongan J. et al Management of colorectal cancer in the еlderly // Clin. Geriatrics. – 2010. – Vol. 18 (Issue 1).</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Papamichael D. et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations // Ann. Oncol. – 2009. – Vol. 20, N 1. – P. 5–16.</mixed-citation><mixed-citation xml:lang="en">Papamichael D. et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations // Ann. Oncol. – 2009. – Vol. 20, N 1. – P. 5–16.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Pope D. et al. Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery // Surg. Oncol. – 2006. – Vol. 15, N 4. – P. 189–197.</mixed-citation><mixed-citation xml:lang="en">Pope D. et al. Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery // Surg. Oncol. – 2006. – Vol. 15, N 4. – P. 189–197.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ramesh H.S. et al. Optimising surgical management of elderly cancer patients // World J. Surg. Oncol. – 2005. – Vol. 3, N 1. – P. 17.</mixed-citation><mixed-citation xml:lang="en">Ramesh H.S. et al. Optimising surgical management of elderly cancer patients // World J. Surg. Oncol. – 2005. – Vol. 3, N 1. – P. 17.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Sanoff H.K., Goldberg R.M. Colorectal cancer treatment in older patients // Gastrointest. Cancer Res. – 2007. – Vol. 1, N 6. – P. 248–253.</mixed-citation><mixed-citation xml:lang="en">Sanoff H.K., Goldberg R.M. Colorectal cancer treatment in older patients // Gastrointest. Cancer Res. – 2007. – Vol. 1, N 6. – P. 248–253.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Sun W. Management and outcome of colorectal cancer in elderly patients // Clin. Colorectal. Cancer. – 2003. – Vol. 3, N 3. – P. 172–173.</mixed-citation><mixed-citation xml:lang="en">Sun W. Management and outcome of colorectal cancer in elderly patients // Clin. Colorectal. Cancer. – 2003. – Vol. 3, N 3. – P. 172–173.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tan K.Y. et al. Colorectal surgery in octogenarian patients--outcomes and predictors of morbidity // Int. J. Colorectal. Dis. – 2009. – Vol. 24, N 2. – P. 185–189.</mixed-citation><mixed-citation xml:lang="en">Tan K.Y. et al. Colorectal surgery in octogenarian patients--outcomes and predictors of morbidity // Int. J. Colorectal. Dis. – 2009. – Vol. 24, N 2. – P. 185–189.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Ugolini G. et al. Can elderly patients with colorectal cancer tolerate planned surgical treatment? A practical approach to a common dilemma // Colorectal. Dis. – 2009. – Vol. 11, N 7. – P. 750–755.</mixed-citation><mixed-citation xml:lang="en">Ugolini G. et al. Can elderly patients with colorectal cancer tolerate planned surgical treatment? A practical approach to a common dilemma // Colorectal. Dis. – 2009. – Vol. 11, N 7. – P. 750–755.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Van Schaik P.M. et al. Micro-metastases in stages I and II colon cancer are a predictor of the development of distant metastases and worse disease-free survival // Eur. J. Surg. Oncol. – 2009. – Vol. 35, N 5. – P. 492–496.</mixed-citation><mixed-citation xml:lang="en">Van Schaik P.M. et al. Micro-metastases in stages I and II colon cancer are a predictor of the development of distant metastases and worse disease-free survival // Eur. J. Surg. Oncol. – 2009. – Vol. 35, N 5. – P. 492–496.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Vather R. et al. Comparison of the possum, P-POSSUM and Cr-POSSUM scoring systems as predictors of postoperative mortality in patients undergoing major colorectal surgery // ANZ J. Surg. – 2006. – Vol. 76, N 9. – P. 812–816.</mixed-citation><mixed-citation xml:lang="en">Vather R. et al. Comparison of the possum, P-POSSUM and Cr-POSSUM scoring systems as predictors of postoperative mortality in patients undergoing major colorectal surgery // ANZ J. Surg. – 2006. – Vol. 76, N 9. – P. 812–816.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
