gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1376Research ArticleНАЦИОНАЛЬНАЯ ШКОЛА ГАСТРОЭНТЕРОЛОГОВ, ГЕПАТОЛОГОВNATIONAL COLLEGE OF GASTROENTEROLOGISTS, HEPATOLOGISTSMALT-лимфома желудка: клиника, диагностика и лечениеMALT-lymphoma of the stomach: clinical presentation, diagnostics and treatmentЛединЕ. В.LedinYe. V.СеряковА. П.SeryakovA. P.АсташовВ. Л.AstashovV. L.ФГУ «Главный военный клинический госпиталь им. Н.Н. Бурденко Минобороны России»Russian Federation2011210220112116978Copyright © Ледин Е.В., Серяков А.П., Асташов В.Л., 20112011Ледин Е.В., Серяков А.П., Асташов В.Л.Ledin Y.V., Seryakov A.P., Astashov V.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1376

Цель обзора. Предоставить современные материалы о диагностике и лечении MALT-лимфомы желудка и опыте ГВКГ им. Н.Н. Бурденко в лечении пациентов с данной патологией.Основные положения. Не так давно в ВОЗ-классификацию опухолей, происходящих из кроветворной и лимфоидной тканей, включена ассоциированная со слизистыми оболочками лимфоидная опухоль, которая терминологически определена как экстранодальная маргинальной зоны В-клеточная лимфома MALT-типа. Доказано, что приблизительно 90% случаев МАLT-лимфом желудка связано с инфицированием H. pylori.Несмотря на большое количество сведений, полученных за два последних десятилетия о клинических и патоморфологических свойствах этого заболевания, его молекулярно-генетических особенностях, оптимального лечебного подхода для данной нозологической формы пока не разработано. Особенно это актуально для местно распространенных стадий заболевания. В статье сделан акцент именно на терапевтические аспекты: на зависимость вида лечения от стадии заболевания, инфицирования Н. pylori, на роль эрадикационной и лучевой терапии, хирургического метода и химиотерапии. Основываясь на полученных данных, мы разработали алгоритм лечения, который рекомендуем к применению в клинической практике для оказания пациенту оптимального объема медицинской помощи.Заключение. Открытия в области биологии MALT-лимфом позволили внедрить в практику новые научно-практические разработки, касающиеся лечения рассматриваемой категории больных.

The aim of review

The aim of review. To present up-to-date data on diagnostics and treatment of MALT-lymphoma of the stomach and experience of N.N.Burdenko Chief military clinical hospital in treatment of patients with this disease.

Original positions

Original positions. Not so long ago mucosa-associated lymphoid tumor was included in WHO classification of hemopoietic and lymphoid tissues tumors, which is terminologically determined as extranodal marginal zone В-cellular lymphoma of the MALT-type. It is proved, that approximately 90% of cases of stomach МАLT-lymphomas are related to H. pylori infection. Despite the extensive data obtained for the last two decades on clinical and pathomorphologic properties of this disease, its molecular genetic features, optimal medical approach for this nosological entity it is not developed yet. It is especially actual for regional stages of disease. The article stresses therapeutic aspects: correspondence of treatment approach to disease stage, presence of Н. pylori infection, role of eradication and radiation therapy, surgery and chemotherapy. Basing on obtained data, original treatment algorithm was developed, which is proposed to application in clinical practice to provide optimal amount of medical care to the patient.

Conclusion

Conclusion. Findings in MALT-lymphoma biology allowed to introduce new scientific and practical treatment projects in practice.

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The authors declare that there are no conflicts of interest present.