gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1437Research ArticleГЕПАТОЛОГИЯHEPATOLOGYДинамическое определение количественного содержания HBsAg в крови в сопоставлении с уровнем вирусной нагрузки у пациентов с хронической HBV-моноинфекциейQuantitative dynamic evaluation HBsAg in blood in comparison to viral load level in patients with chronic HBV-monoinfectionДудинаК. Р.DudinaK. R.ЗнойкоО. О.ZnoykoO. O.ШутькоС. А.ShutkoS. A.КлимоваЕ. А.KlimovaYe. A.КузинаЛ. Е.KuzinaL. Ye.БрагинскийД. М.BraginskyD. M.БлохинаН. П.BlokhinaN. P.ЮщукН. Д.YushchukN. D.2011060620112143742Copyright © Дудина К.Р., Знойко О.О., Шутько С.А., Климова Е.А., Кузина Л.Е., Брагинский Д.М., Блохина Н.П., Ющук Н.Д., 20112011Дудина К.Р., Знойко О.О., Шутько С.А., Климова Е.А., Кузина Л.Е., Брагинский Д.М., Блохина Н.П., Ющук Н.Д.Dudina K.R., Znoyko O.O., Shutko S.A., Klimova Y.A., Kuzina L.Y., Braginsky D.M., Blokhina N.P., Yushchuk N.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1437

Цель исследования. Анализ количественного содержания HBsAg в крови в зависимости от уровня виремии HBV у пациентов с различными вариантами естественного течения хронической HBV-инфекции при динамическом обследовании в течение 1,5–2 лет.Материал и методы. В исследование включено135 пациентов с хронической HBV-моноинфекцией, у которых в динамике проводилось определение уровня виремии HBV методом полимеразной цепной реакции и количественное определение HBsAg в крови методом хемилюминесценции.Результаты. Концентрация HBsAg в крови значимо различается между НВе-позитивной и НВе-негативной фазами хронической HBV-инфекции. При анализе колебаний серологического уровня HBsAg у больных НВе-негативным хроническим гепатитом В при динамическом наблюдении в течение 1,5–2 лет не выявлено связи концентрации HBsAg с уровнем виремии HBV. Полученные данные о низкой концентрации HBsAg у части неактивных носителей HBV позволяют рассматривать определение количественного содержания HBsAg в качестве теста, дающего дополнительный критерий диагноза «неактивное носительство вируса гепатита В».

Aim of investigation

Aim of investigation. Quantitative analysis of HBsAg contents in the blood in relation to HBV viremia level in patients with various variants of natural course of chronic HBV-infection at dynamic evaluation within 1,5–2 years.

Material and methods

Material and methods. Overall 135 patients with chronic HBV-monoinfection were included in original study. Dynamic assessment of HBV viremia level by polymerase chain reaction and quantitative assessment of blood HBsAg by chemiluminescence was carried out.

Results

Results. Blood HBsAg concentration significantly differed between НВе-positive and НВе-negative phases of chronic HBV-infection. At analysis of serum HBsAg fluctuations in НВе-negative chronic hepatitis B patients no correlation of HBsAg concentration with the level of HBV viremia was revealed at dynamic observation for 1,5 to 2 years. Received data on low HBsAg concentration in a part of inactive HBV carriers allow to consider, that quantitative assessment of HBsAg contents as a supplemental criterion for diagnosis of «hepatitis B virus inactive carriage».

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The authors declare that there are no conflicts of interest present.