gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1469Research ArticleРЕДАКЦИОННАЯEDITORIALПерспективы и проблемы применения стволовых клеток в гастроэнтерологииStem cells in gastroenterology: prospects and problemsБуеверовА. О.BuyeverovA. O.ИвашкинВ. Т.IvashkinV. T.Государственное образовательное учреждение высшего профессионального образования «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минзравсоцразвития РФRussian Federation201125122011216411Copyright © Буеверов А.О., Ивашкин В.Т., 20112011Буеверов А.О., Ивашкин В.Т.Buyeverov A.O., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1469

Цель обзора. Обобщить накопленные сведения о роли стволовых клеток (СК) в лечении заболеваний гастроэнтерологического профиля.Основные положения. Клеточная терапия – относительно новое и, вероятно, многообещающее направление в лечении многих тяжелых заболеваний, при которых традиционными методами не удается достичь должных результатов. В терапевтическом аспекте патологии желудочно-кишечного тракта и печени наиболее перспективными на данном этапе представляются воспалительные заболевания кишечника, колоректальный рак и декомпенсированный цирроз печени.Вместе с тем клиническое применение СК сопряжено с рядом серьезных проблем: иммунное отторжение и реакция «трансплантат против хозяина», трансформация в опухолевые клетки, а также этические и религиозные ограничения.Заключение. Применение СК в клинической гастроэнтерологии на сегодняшний день преждевременно. Их эффективность и безопасность требует подтверждения в мультицентровых рандомизированных исследованиях.

The aim of review

The aim of review. To generalize cumulative data on the role of stem cells (SC) in treatment of gastroenterological diseases.

Original positions

Original positions. Cell-based treatment is rather new and, probably, promising trend in treatment of many severe diseases in which traditional methods fail to achieve due results. In therapeutic aspect of gastrointestinal and liver diseases inflammatory bowel diseases, colorectal cancer and decompensated liver cirrhosis seem to be most perspective at the present stage. At the same time clinical application of SC is associated to array of serious problems: immune rejection and «graft-versus-host» response, neoplastic transformation as well as ethical and religious restrictions.

Conclusion

Conclusion. Application SC in clinical gastroenterology is premature today. Their efficacy and safety requires confirmation in multicenter randomized trials.

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The authors declare that there are no conflicts of interest present.