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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1478</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВОСТИ КОЛОПРОКТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEWS OF COLOPROCTOLOGY</subject></subj-group></article-categories><title-group><article-title>Эффективность илеостомии при болезни Крона толстой кишки с перианальными поражениями</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy of ileostomy in Crohn's disease of the large intestine with perianal involvement</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>Yu. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашников</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashnikov</surname><given-names>V. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болихов</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bolikhov</surname><given-names>K. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варданян</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vardanyan</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халиф</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalif</surname><given-names>I. L.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГУ «ГНЦ колопроктологии» Минздравсоцразвития России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2011</year></pub-date><volume>21</volume><issue>6</issue><fpage>64</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шелыгин Ю.А., Кашников В.Н., Болихов К.В., Варданян А.В., Халиф И.Л., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Шелыгин Ю.А., Кашников В.Н., Болихов К.В., Варданян А.В., Халиф И.Л.</copyright-holder><copyright-holder xml:lang="en">Shelygin Y.A., Kashnikov V.N., Bolikhov K.V., Vardanyan A.V., Khalif I.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1478">https://www.gastro-j.ru/jour/article/view/1478</self-uri><abstract><p>Цель исследования. Оценить эффективность илеостомии у пациентов с болезнью Крона толстой кишки с перианальными поражениями.Материал и методы. В исследование включено 43 пациента с болезнью Крона толстой кишки с перианальными поражениями, которым за период с января 1998 г. по июль 2009 г. в ГНЦ колопроктологии выполнялась операция – илеостомия. По распространенности воспалительного процесса больные распределились следующим образом: у 4 (9,3%) – проктосигмоидит, у 15 (34,8%) – левостороннее поражение и у 24 (55,9%) – тотальное поражение толстой кишки. Перианальные поражения представлены следующими видами: язвы-трещины анального канала – у 6 (14%) пациентов, свищи прямой кишки – у 12 (27,9%), стриктуры анального канала – у 3 (6,9%), сочетания двух и трех видов перианальных поражений встречались у 22 (51,2%) больных.Результаты. Прослежено 35 (81,3%) из 43 пациентов в сроки от 1 до 12 мес (М=5,5±2,6). Местное консервативное лечение проходили 24 (68,5%) из 35 больных в период от 1 до 6 мес (М=4,1±1,1), заживления удалось добиться в 11 случаях к 2,8±1,4 месяцу. Хирургическое лечение перианальных поражений выполнялось у 11 (31,5%) пациентов в период от 2 до 12 мес (М=5,9±3,6), заживление отмечалось у 9 больных в среднем к 4,5±2,2 месяцу в сроки от 2 до 9 мес.Заключение. При наличии тотального поражения толстой кишки в сочетании с двумя и более видами перианальных поражений, сопровождающихся выраженными метаболическими нарушениями, илеостомия должна применяться как первый этап хирургического лечения.</p></abstract><trans-abstract xml:lang="en"><sec><title>Aim of investigation</title><p>Aim of investigation. To estimate efficacy of ileostomy in patients with Crohn's disease of the large intestine with perianal involvement.</p></sec><sec><title>Material and methods</title><p>Material and methods. Overall 43 patients with Crohn's disease of the large intestine with perianal involvement who underwent ileostomy in January, 1998 to July, 2009 in The State scientific center of coloproctology were included in original study. According to the spread of inflammatory process patients were distributed as follows: in 4 patients (9,3%) – proctosigmoiditis, in 15 (34,8%) – left-side lesion and in 24 (55,9%) – total involvement of the large intestine. Perianal lesions were presented by following types: ulcers-anal fissures – in 6 (14%) patients, rectal fistulas – in 12 (27,9%), strictures of anal canal – in 3 (6,9%), combinations of two and three types of perianal lesions were present in 22 (51,2%) patients. Results. Thirty five of 43 patients (81,3%) were monitored in terms from 1 to 12 months (М=5,5±2,6). Twenty four of 35 (68,5%) patients underwent local conservative treatment in period from 1 to 6 months (М=4,1±1,1), that provided healing in 11 cases to 2,8±1,4 month. Surgical treatment of perianal lesions was performed in 11 (31,5%) patients in terms from 2 to 12 months (М=5,9±3,6), healing was obtained in 9 patients on average up to 4,5±2,2 month in terms from 2 to 9 months.</p></sec><sec><title>Conclusion</title><p>Conclusion. At total involvement of the large intestine in combination to two and more types of the perianal lesions along with severe metabolic disorders, ileostomy should be applied as the first-line surgical treatment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Крона</kwd><kwd>перианальные поражения</kwd><kwd>илеостомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Crohn's disease</kwd><kwd>perianal lesions</kwd><kwd>ileostomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Адлер Г. Болезнь Крона и язвенный колит. – М.: «Гэотар-Мед», 2001.</mixed-citation><mixed-citation xml:lang="en">Адлер Г. Болезнь Крона и язвенный колит. – М.: «Гэотар-Мед», 2001.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусова Е.А. Биологическая стратегия в лечении воспалительных заболеваний кишечника // Фарматека. – 2006. – № 6. – C. 14–16.</mixed-citation><mixed-citation xml:lang="en">Белоусова Е.А. Биологическая стратегия в лечении воспалительных заболеваний кишечника // Фарматека. – 2006. – № 6. – C. 14–16.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев Г.И., Михайлова Т.Л., Фролов С.А. и др. Лапароскопическая илеостомия в лечении воспалительных заболеваний толстой кишки: Пособие для врачей, 2004.</mixed-citation><mixed-citation xml:lang="en">Воробьев Г.И., Михайлова Т.Л., Фролов С.А. и др. Лапароскопическая илеостомия в лечении воспалительных заболеваний толстой кишки: Пособие для врачей, 2004.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Athanasiadis S., Girona J. Neue Behandlungsmethoden der perianalen Fisteln bei Morbus Crohn // Langenbecks Arch. Chir. – 1983. – Vol. 360. – S. 119–132.</mixed-citation><mixed-citation xml:lang="en">Athanasiadis S., Girona J. Neue Behandlungsmethoden der perianalen Fisteln bei Morbus Crohn // Langenbecks Arch. Chir. – 1983. – Vol. 360. – S. 119–132.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fammer R.G., Hawk W.A., Turnbull R.B. Clinical patterns in Crohn’s disease: a statistical of 615 cases // Gastroenterology. – 1975. – Vol. 68. – P. 627–635.</mixed-citation><mixed-citation xml:lang="en">Fammer R.G., Hawk W.A., Turnbull R.B. Clinical patterns in Crohn’s disease: a statistical of 615 cases // Gastroenterology. – 1975. – Vol. 68. – P. 627–635.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fichera A., Michelassi F. Surgical treatment of Crohn’s disease // J. Gastrointest. Surg. – 2007. – Vol. 11, N 6. – P. 791–803.</mixed-citation><mixed-citation xml:lang="en">Fichera A., Michelassi F. Surgical treatment of Crohn’s disease // J. Gastrointest. Surg. – 2007. – Vol. 11, N 6. – P. 791–803.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon P.H. Santhat Nivatvongs Principles and practice of surgery for the colon, rectum, and anus / 3rd ed., 2007.</mixed-citation><mixed-citation xml:lang="en">Gordon P.H. Santhat Nivatvongs Principles and practice of surgery for the colon, rectum, and anus / 3rd ed., 2007.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Greenstein A.J., Sachar D.B., Greenstein R.J. et al. Intra-abdominal abscess in Crohn’s (ileo) colitis // Am. J. Surg. – 1985. – Vol. 143. – P. 27–37.</mixed-citation><mixed-citation xml:lang="en">Greenstein A.J., Sachar D.B., Greenstein R.J. et al. Intra-abdominal abscess in Crohn’s (ileo) colitis // Am. J. Surg. – 1985. – Vol. 143. – P. 27–37.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">McClane S.J., Rombeau J.L. Anorectal Crohn’s disease // Surg. Clin. North Am. – 2001. – Vol. 81, N 1. – P. 169–183.</mixed-citation><mixed-citation xml:lang="en">McClane S.J., Rombeau J.L. Anorectal Crohn’s disease // Surg. Clin. North Am. – 2001. – Vol. 81, N 1. – P. 169–183.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Michelassi F., Balestracci T., Chappell R. et al. Primary and recurrent Crohn’s disease. Experience with 1379 patients // Ann. Surg. – 1991. – Vol. 214. – P. 230– 238.</mixed-citation><mixed-citation xml:lang="en">Michelassi F., Balestracci T., Chappell R. et al. Primary and recurrent Crohn’s disease. Experience with 1379 patients // Ann. Surg. – 1991. – Vol. 214. – P. 230– 238.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Michelassi F., Melis M., Rubin M., Hurst R.D. Surgical treatment of anorectal complications in Crohn’s disease // Surgery. – 2000. – Vol. 128, N 4. – P. 597–603.</mixed-citation><mixed-citation xml:lang="en">Michelassi F., Melis M., Rubin M., Hurst R.D. Surgical treatment of anorectal complications in Crohn’s disease // Surgery. – 2000. – Vol. 128, N 4. – P. 597–603.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller M.H., Geis M., Glatzle J. et al. Risk of fecal diversion in complicated perianal Crohn’s disease // J. Gastrointest. Surg. – 2007. – Vol. 11, N 4. – P. 529–537.</mixed-citation><mixed-citation xml:lang="en">Mueller M.H., Geis M., Glatzle J. et al. Risk of fecal diversion in complicated perianal Crohn’s disease // J. Gastrointest. Surg. – 2007. – Vol. 11, N 4. – P. 529–537.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Whiteford M.H., Kilkenny J., Hyman N. et al. Practice parameters for the treatment of perianal abscess and fistula-in-ano (revised) // Dis. Colon Rectum. – 2005. – Vol. 48, N 7. – P. 1337–1342.</mixed-citation><mixed-citation xml:lang="en">Whiteford M.H., Kilkenny J., Hyman N. et al. Practice parameters for the treatment of perianal abscess and fistula-in-ano (revised) // Dis. Colon Rectum. – 2005. – Vol. 48, N 7. – P. 1337–1342.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
