The aim of review

gastro-j

Российский журнал гастроэнтерологии, гепатологии, колопроктологии

Russian Journal of Gastroenterology, Hepatology, Coloproctology

1382-43762658-6673

«Gastro» LLC

gastro-j-1485

Research Article

ЛЕКЦИИ И ОБЗОРЫ

LECTURES AND REVIEWS

Основные причины лихорадки у пациентов с нарушением функции печени

Leading causes of fever in patients with liver function disorders

Ивашкин

В. Т.

Ivashkin

V. T.

Морозова

М. А.

Morozova

M. A.

Маевская

М. В.

Mayevskaya

M. V.

Московская медицинская академия им. И.М. СеченоваRussian Federation

2010

02022010

2012129

2010

Ивашкин В.Т., Морозова М.А., Маевская М.В.

Ivashkin V.T., Morozova M.A., Mayevskaya M.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gastro-j.ru/jour/article/view/1485

Цель обзора. Анализ данных литературы, касающихся возможных причин лихорадки у больных с нарушением функции печени. В статье освещены патофизиологические механизмы развития лихорадки. Представлен алгоритм обследования пациента с нарушением функции печени и лихорадкой.Основные положения. Лихорадка у пациентов с печеночной недостаточностью может быть вызвана как инфекционными, так и неинфекционными причинами. Наиболее частыми причинами лихорадки при нарушении функции печени служат инфекционные осложнения, что объясняется иммунодефицитным состоянием данной категории больных. Немаловажную роль в развитии лихорадки у пациентов с циррозом печени играют развивающийся у них синдром избыточного бактериального роста, процессы бактериальной транслокации и, как следствие, эндотоксемия. В случае невыявления очага инфекции следует помнить о вероятности развития неинфекционной лихорадки в рамках ответа острой фазы, неопластического процесса или реакции на применяемые медикаментозные средства.Заключение. При развитии лихорадки у пациентов с печеночной недостаточностью необходимо проведение дифференциальной диагностики причин повышения температуры, что позволит разработать более дифференцированные подходы к лечению.

The aim of review

The aim of review. Analysis of literature data on the possible causes of fever at patients with disorders of liver function. Article presents pathophysiological mechanisms of development of fever. The algorithm of assessment of patient with disorder of liver function and fever is submitted.

Original positions

Original positions. Fever in patients with liver failure can be caused both by infectious and non-infectious causes. Infections are the most frequent causes of fever at disorder of the liver function, that accounts for immunodeficiency state at this category of patients. An important role in development of fever at patients with liver cirrhosis is bacterial overgrowth syndrome, bacterial translocation processes and, as a consequence, endotoxemia. If the site of infection is not detected, it is necessary to keep in mind the option of development of non-infectious fever within acute phase reaction, neoplastic process or reaction to applied pharmaceutical agents.

Conclusion

Conclusion. At development of fever at patients with liver failure carrying out differential diagnostics of the causes of body temperature elevation is necessary that allows more differentiated approaches to treatment.

лихорадкацирроз печенипеченочная недостаточностьинфекционные осложненияэндотоксемия

feverliver cirrhosisliver disfuntioninfectionendotoxemia

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The authors declare that there are no conflicts of interest present.