The aim of review

gastro-j

Российский журнал гастроэнтерологии, гепатологии, колопроктологии

Russian Journal of Gastroenterology, Hepatology, Coloproctology

1382-43762658-6673

«Gastro» LLC

gastro-j-1506

Research Article

ЛЕКЦИИ И ОБЗОРЫ

LECTURES AND REVIEWS

Экспериментальные методы изучения портальной гипертензии

Experimental methods of portal hypertension studying

Гарбузенко

Д. В.

Garbuzenko

D. V.

Челябинская государственная медицинская академияRussian Federation

2010

30042010

202412

2010

Гарбузенко Д.В.

Garbuzenko D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gastro-j.ru/jour/article/view/1506

Цель обзора. Представить методы изучения портальной гипертензии и способы ее медикаментозной коррекции в эксперименте.Основные положения. Для изучения сложных патофизиологических нарушений, свойственных портальной гипертензии, используются различные экспериментальные модели, которые позволяют дать им комплексную оценку и разработать способы адекватной коррекции. В настоящее время на лабораторных животных детализированы механизмы развития гипердинамического циркуляторного статуса, исследования ex vivo дали физиологическую характеристику медиаторам, вызывающим спланхническую вазодилатацию и увеличение сосудистого тонуса в цирротически измененной печени, а методы молекулярной биологии идентифицировали дефекты в сигнализирующих путях, ответственных за нарушение метаболизма этих веществ.Заключение. В последние годы применение различных экспериментальных моделей портальной гипертензии способствовало прогрессу не только в понимании лежащих в ее основе патофизиологических механизмов, но и разработке новых перспективных методов лечения. Дальнейшие рандомизированные контролируемые клинические испытания дадут возможность определить их безопасность и эффективность при сравнении с традиционными способами терапии.

The aim of review

The aim of review. To present methods of studying of portal hypertension and means of its pharmacological treatment in experiment settings.

Original positions

Original positions. To study complex pathophysiological disorders, innate to portal hypertension, various pilot models providing complex evaluation and development of adequate treatment methods are used. Nowadays mechanisms of hyperdynamic circulatory status development are detailed on laboratory animals. Ex vivo studies gave physiological characteristic to the mediators causing splanchnic vasodilation and increasing of vascular tension in cirrhotic liver, and methods of molecular biology identified defects in signalling routes responsible for disorders of metabolism of these substances.

Conclusion

Conclusion. In the last years application of various pilot models of portal hypertension promoted progress not only in understanding of pathophysiological mechanisms laying in its basis, but also development of new perspective methods of treatment. The further randomized controlled clinical studies will help to determine their safety and efficacy comparing to traditional treatment methods.

портальная гипертензиямоделированиепатогенезтерапия

portal hypertensionmodelingpathogenesistreatment

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The authors declare that there are no conflicts of interest present.