<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1509</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Распространенность инфекции H. pylori среди населения Москвы</article-title><trans-title-group xml:lang="en"><trans-title>Prevalence of infection H. pylori in Moscow population</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герман</surname><given-names>C. В.</given-names></name><name name-style="western" xml:lang="en"><surname>German</surname><given-names>S. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зыкова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Zykova</surname><given-names>I. Ye.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Модестова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Modestova</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермаков</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yermakov</surname><given-names>N. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГУ НИИ экологии человека и гигиены окружающей среды им. А.Н. Сысина РАМН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>30</day><month>04</month><year>2010</year></pub-date><volume>20</volume><issue>2</issue><fpage>25</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Герман C.В., Зыкова И.Е., Модестова А.В., Ермаков Н.В., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Герман C.В., Зыкова И.Е., Модестова А.В., Ермаков Н.В.</copyright-holder><copyright-holder xml:lang="en">German S.V., Zykova I.Y., Modestova A.V., Yermakov N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1509">https://www.gastro-j.ru/jour/article/view/1509</self-uri><abstract><p>Цель исследования. Изучить распространенность пилорической геликобактерной инфекции среди трудоспособного населения г. Москвы.Материал и методы. Диагностика инфекции Н. pylori проводилась у 863 работающих жителей мегаполиса. В сыворотке крови иммуноферментным методом определяли антигеликобактерные антитела класса IgG. У 264 человек с диагностированной инфекцией Н. pylori изучалось наличие антител к CagA­антигену. Путем случайной выборки было взято интервью по разработанной нами анкете у 634 человек.Результаты. Обнаружена чрезвычайно высокая распространенность инфекции – 88%. Выявлены факторы риска инфицирования среди жителей города: возраст, недостаточное образование, плохие жилищные условия (проживание в общежитии или в коммунальной квартире), отсутствие канализации, контакт со сточными водами. Не отмечено зависимости распространенности инфекции от пола обследованных, употребления некипяченой московской водопроводной воды для питья и от контакта с домашними животными.Заключение. Москва относится к городам с чрезвычайно высокой распространенностью Н. pylori­-инфекции, с преобладанием вирулентных штаммов бактерии. Установлены факторы риска инфицирования Н. pylori в мегаполисе.</p></abstract><trans-abstract xml:lang="en"><sec><title>Aim of investigation</title><p>Aim of investigation. To study the prevalence of H. pylori infection among able-bodied population of Moscow.</p></sec><sec><title>Material and methods</title><p>Material and methods. Diagnostics of Н. pylori infection was implemented at 863 working inhabitants of megacity. Antihelicobacter IgG antibodies were determined in blood serum by immunoenzyme method. In 264 persons with diagnosed Н. pylori infection antiCagA-antibodies were studied. Interview of 634 persons have been taken using original questionnaire by random sample.</p></sec><sec><title>Results</title><p>Results. Extremely high prevalence of infection – 88% was found. Risk factors of infection among population of the town were revealed: age, poor education, bad living conditions (residing at hostel or in shared apartment), absence of the water drain and contact with sewage. No relation of infection prevalence to gender, drinking of non-boiled Moscow tap water and contact with domestic animals was marked.</p></sec><sec><title>Conclusion</title><p>Conclusion. Moscow falls into group of cities with extremely high Н.pylori-infection prevalence, with predominance of virulent bacteria strains. Risk factors of Н. pylori infection in megacity were revealed.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекция Н. pylori</kwd><kwd>распространенность инфицирования</kwd><kwd>антитела против Н. pylori</kwd><kwd>факторы риска</kwd><kwd>рак желудка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Н. pylori infection</kwd><kwd>infection prevalence</kwd><kwd>anti-Н.pylori antibodies</kwd><kwd>risk factors</kwd><kwd>stomach cancer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Положенцев С.Д., Султанов В.К. и др. О патогенной роли Helicobacter pylori // Тер. арх. – 1993. – № 2. – С. 11–13.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В.Т., Положенцев С.Д., Султанов В.К. и др. О патогенной роли Helicobacter pylori // Тер. арх. – 1993. – № 2. – С. 11–13.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Исаков В.А., Доморадский И.В. Хеликобактериоз. – М.: Медпрактика, 2003. – 411 с.</mixed-citation><mixed-citation xml:lang="en">Исаков В.А., Доморадский И.В. Хеликобактериоз. – М.: Медпрактика, 2003. – 411 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Калинин А.Д., Спесивцев В.Н., Скворцов С.В., Лыцарь Б.Н. Инфицированность Helicobacter pylori различных групп больных многопрофильного стационара и доноров крови // Клин. мед. – 1993. – № 3. – С. 38–39.</mixed-citation><mixed-citation xml:lang="en">Калинин А.Д., Спесивцев В.Н., Скворцов С.В., Лыцарь Б.Н. Инфицированность Helicobacter pylori различных групп больных многопрофильного стационара и доноров крови // Клин. мед. – 1993. – № 3. – С. 38–39.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Курилович С.А., Решетников О.В., Шлыкова Л.Г. Некоторые итоги и перспективы изучения Helicobacter pylori-инфекции в Западной Сибири // Педиатрия. – 2002. – № 2 (приложение). – С. 65–71.</mixed-citation><mixed-citation xml:lang="en">Курилович С.А., Решетников О.В., Шлыкова Л.Г. Некоторые итоги и перспективы изучения Helicobacter pylori-инфекции в Западной Сибири // Педиатрия. – 2002. – № 2 (приложение). – С. 65–71.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Abasivanik M.F., Tunc M., Salih B.A. Enzyme immunoassay and immunoblotting analysis of Helicobacter pylori infection in Turkish asymptomatic subjects // Diagn. Microbiol. Infect. Dis. – 2004. – Vol. 50, N 3. – P. 173–177.</mixed-citation><mixed-citation xml:lang="en">Abasivanik M.F., Tunc M., Salih B.A. Enzyme immunoassay and immunoblotting analysis of Helicobacter pylori infection in Turkish asymptomatic subjects // Diagn. Microbiol. Infect. Dis. – 2004. – Vol. 50, N 3. – P. 173–177.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Brown L.M. Helicobacter pylori: Epidemiology and routes of transmission // Epidemiol. Rev. – 2000. – Vol. 22. – P. 283–297.</mixed-citation><mixed-citation xml:lang="en">Brown L.M. Helicobacter pylori: Epidemiology and routes of transmission // Epidemiol. Rev. – 2000. – Vol. 22. – P. 283–297.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Celinski K., Kurzeja-Miroslaw A., Slomka M. et al. The effects of environmental factors on the prevalence of Helicobacter pylori infection in inhabitants of Lublin province // Ann. Agric. Environ. Med. – 2006. – Vol. 13. – P. 185–191.</mixed-citation><mixed-citation xml:lang="en">Celinski K., Kurzeja-Miroslaw A., Slomka M. et al. The effects of environmental factors on the prevalence of Helicobacter pylori infection in inhabitants of Lublin province // Ann. Agric. Environ. Med. – 2006. – Vol. 13. – P. 185–191.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Crew K.D., Neugut A.I. Epidemioilogy of gastric cancer // World J. Gastroenterol. – 2006. – Vol. 12, N 3. – P. 354–362.</mixed-citation><mixed-citation xml:lang="en">Crew K.D., Neugut A.I. Epidemioilogy of gastric cancer // World J. Gastroenterol. – 2006. – Vol. 12, N 3. – P. 354–362.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">The EUROGAST Study Group. An international association between Helicobacter pylori infection and gastric cancer (no authors listed) // Lancet. – 1993. – Vol. 341, N 8861. – P. 1668.</mixed-citation><mixed-citation xml:lang="en">The EUROGAST Study Group. An international association between Helicobacter pylori infection and gastric cancer (no authors listed) // Lancet. – 1993. – Vol. 341, N 8861. – P. 1668.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Fan X.G., Chua A., Li T.G. et al. Survival of Helicobacter pylori in milk and tap water // J. Gastroenterol. Hepatol. – 1998. – Vol. 13, N 11. – P. 1096–1098.</mixed-citation><mixed-citation xml:lang="en">Fan X.G., Chua A., Li T.G. et al. Survival of Helicobacter pylori in milk and tap water // J. Gastroenterol. Hepatol. – 1998. – Vol. 13, N 11. – P. 1096–1098.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fawcett J.P., Barbezat G.O., Poulton R. et al. Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26 // World J. Gastroenterol. – 2005. – Vol. 11, N 21. – P. 3273–3276.</mixed-citation><mixed-citation xml:lang="en">Fawcett J.P., Barbezat G.O., Poulton R. et al. Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26 // World J. Gastroenterol. – 2005. – Vol. 11, N 21. – P. 3273–3276.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Friis L., Engstrand L., Edling C. Prevalence of Helico­bacter pylori infection among sewage workers // Scand. J. Work Environ. Health. – 1996. – Vol. 22. – P. 364–368.</mixed-citation><mixed-citation xml:lang="en">Friis L., Engstrand L., Edling C. Prevalence of Helico­bacter pylori infection among sewage workers // Scand. J. Work Environ. Health. – 1996. – Vol. 22. – P. 364–368.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Jeggli S., Steiner D., Joller H. et al. Hepatitis E. Helicobacter pylori? And gastrointestinal symptoms in workers exposed to waste water // Occup. Environ. Med. – 2004. – Vol. 61. – P. 622–627.</mixed-citation><mixed-citation xml:lang="en">Jeggli S., Steiner D., Joller H. et al. Hepatitis E. Helicobacter pylori? And gastrointestinal symptoms in workers exposed to waste water // Occup. Environ. Med. – 2004. – Vol. 61. – P. 622–627.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jemal A., Thomas A., Murray T., Thun M. Cancer statistic, 2002 // CA Cancer J. Clin. – 2002. – Vol. 52. – P. 23–47.</mixed-citation><mixed-citation xml:lang="en">Jemal A., Thomas A., Murray T., Thun M. Cancer statistic, 2002 // CA Cancer J. Clin. – 2002. – Vol. 52. – P. 23–47.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kato M., Asako M., Nakamura T. et al. Helicobacter pylori eradication prevents the development of gastric cancer – results of a long-term retrospective study in Japan // Aliment. Pharmacol. Ther. – 2006. – Vol. 24 (suppl. 4). – P. 203–206.</mixed-citation><mixed-citation xml:lang="en">Kato M., Asako M., Nakamura T. et al. Helicobacter pylori eradication prevents the development of gastric cancer – results of a long-term retrospective study in Japan // Aliment. Pharmacol. Ther. – 2006. – Vol. 24 (suppl. 4). – P. 203–206.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kikuchi S., Yagyu K., Obata Y. et al. Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in JACC study // J. Epidemiol. – 2005. – Vol. 15. – N 5. – P. 197–204.</mixed-citation><mixed-citation xml:lang="en">Kikuchi S., Yagyu K., Obata Y. et al. Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in JACC study // J. Epidemiol. – 2005. – Vol. 15. – N 5. – P. 197–204.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kokkola A., Louhimo J., Puolakkainen P. Helicobacter pylori infection and low serum pepsinogen 1 level as risk factors for gastric carcinoma // World J. Gastroenterol. – 2005. – Vol. 21. – Vol. 11, N 7. – P. 1032–1036.</mixed-citation><mixed-citation xml:lang="en">Kokkola A., Louhimo J., Puolakkainen P. Helicobacter pylori infection and low serum pepsinogen 1 level as risk factors for gastric carcinoma // World J. Gastroenterol. – 2005. – Vol. 21. – Vol. 11, N 7. – P. 1032–1036.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Mitipat N., Siripermpool P., Jadwattanakul T., Chaunt­hongkum S. The prevalence of Helicobacter pylori infection in patients with gastrointestinal symptoms in Chon Buri, Thailand // Southeast Asian J. Trop. Med. Public Health. – 2005. – Vol. 36, N 2. – P. 341–346.</mixed-citation><mixed-citation xml:lang="en">Mitipat N., Siripermpool P., Jadwattanakul T., Chaunt­hongkum S. The prevalence of Helicobacter pylori infection in patients with gastrointestinal symptoms in Chon Buri, Thailand // Southeast Asian J. Trop. Med. Public Health. – 2005. – Vol. 36, N 2. – P. 341–346.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Parkin D.M. International variation // Oncogene. – 2001. – Vol. 23. – P. 6329–6340.</mixed-citation><mixed-citation xml:lang="en">Parkin D.M. International variation // Oncogene. – 2001. – Vol. 23. – P. 6329–6340.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Plonka M., Konturek P.C., Bielinski W. et al. Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children // Aliment. Pharmacol. Ther. – 2006. – Vol. 24 (suppl. 4). – P. 160–168.</mixed-citation><mixed-citation xml:lang="en">Plonka M., Konturek P.C., Bielinski W. et al. Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children // Aliment. Pharmacol. Ther. – 2006. – Vol. 24 (suppl. 4). – P. 160–168.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Plummer M., Franceschi S., Munos N. Epidemiology of gastric cancer // IARC Sci. Publ. – 2004. – Vol. 157. – P. 311–326.</mixed-citation><mixed-citation xml:lang="en">Plummer M., Franceschi S., Munos N. Epidemiology of gastric cancer // IARC Sci. Publ. – 2004. – Vol. 157. – P. 311–326.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Shi R., Xu S., Zhang H. et al. Prevalence and risk factors for Helicobacter pylori infection in Chinese populations // Helicobacter. – 2008. – Vol. 13, N 2. – P. 157–165.</mixed-citation><mixed-citation xml:lang="en">Shi R., Xu S., Zhang H. et al. Prevalence and risk factors for Helicobacter pylori infection in Chinese populations // Helicobacter. – 2008. – Vol. 13, N 2. – P. 157–165.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sipponen P., Marshall B.J. Gastritis and gastric cancer. Western countries // Gastroenterol. Clin. North Am. – 2000. – Vol. 29. – P. 579–592.</mixed-citation><mixed-citation xml:lang="en">Sipponen P., Marshall B.J. Gastritis and gastric cancer. Western countries // Gastroenterol. Clin. North Am. – 2000. – Vol. 29. – P. 579–592.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
