gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1520Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSГастроинтестинальные миофибробласты – роль в регуляции физиологической активности и репарации желудочно-кишечного трактаGastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tractБариновЭ. Ф.BarinovE. F.СулаеваО. Н.SulayevaO. N.Донецкий национальный медицинский университет им. М. ГорькогоUkraine201030062010203918Copyright © Баринов Э.Ф., Сулаева О.Н., 20102010Баринов Э.Ф., Сулаева О.Н.Barinov E.F., Sulayeva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1520

Цель обзора. Проанализировать органоспецифические особенности гастроинтестинальных миофибробластов, функциональные свойства, роль в эмбриогенезе и заживлении язвенных дефектов стенки желудочно-кишечного тракта (ЖКТ).Основные положения. Обсуждается морфология, маркёры, источники и стимуляторы формирования миофибробластов, их участие в формировании микрониши для эпителиальных стволовых клеток, кинетике покровного эпителия, ангиогенезе, контроле сосудистой проницаемости. Эти функции связаны с широким спектром секреторных продуктов миофибробластов, образующих молекулы базальной мембраны, компоненты матрикса и факторы роста. Интестинальные миофиброласты являются пейсмеккерами для гладких миоцитов ЖКТ, модулируют нейротрансмиссию, участвуют в модуляции иммунного ответа, играя критическую роль в репарации эрозий и язв ЖКТ.

The aim of review

The aim of review. To analyze organ-specific features of gastrointestinal myofibroblasts, functional properties, role in embryogenesis and healing of ulcers of gastro-intestinal tract (GIT).

Original positions

Original positions. Morphology, markers, origin and stimulators of development of myofibroblasts, their involvement in formation of microniche for epithelial stem cells, kinetics of tegmental epithelium, angiogenesis, control of vascular permeability is discussed. Thesefunctions are related to wide spectrum of myofibroblast secretory products, producing molecules of basal membrane, components of matrix and growth factors. Intestinal myofibroblasts are pacemakers for smooth myocytes of GIT, they modulate neurotransmission, participate in modulation of immune response, playing a critical role in reparation of erosions and ulcers of GIT.

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The authors declare that there are no conflicts of interest present.