gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2017-27-3-11-17gastro-j-153Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSРоль микробиома в развитии заболеваний поджелудочной железыMicrobiome role in pancreatic diseases developmentЕвсютинаЮ. В.EvsyutinaYu. V.uselina@mail.ruИвашкинВ. Т.IvashkinV. T.noemail@neicon.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова»РоссияFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityRussian Federation2017120820182731117Copyright © Евсютина Ю.В., Ивашкин В.Т., 20182018Евсютина Ю.В., Ивашкин В.Т.Evsyutina Y.V., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/153

Цель обзора. Представить современные данные о механизмах развития заболеваний поджелудочной железы и роли микробиомажелудочно-кишечноготракта(ЖКТ) и ротовой полости в патогенезе панкреатита. Основные положения. Для острого панкреатита характерны дисфункция кишечного барьера, избыточный бактериальный рост и эндотоксинемия. Важную роль в этих процессах играют образраспознающие (толл и нодподобные) рецепторы и микроорганизмассоциированные молекулярные паттерны. Получены данные об изменении микробиома ЖКТ и ротовой полости у пациентов с патологией поджелудочной железы. Так, инфекцияHelicobacterpyloriможет играть роль в развитии аутоиммунного панкреатита и рака поджелудочной железы,PorphyromonasgingivalisиAggregatibacter actinomycetemcomitans- в развитии рака поджелудочной железы. Заключение. Результаты проведенных исследований свидетельствуют об изменении микробиома ЖКТ и ротовой полости у пациентов с патологией поджелудочной железы. Учитывая способность пробиотиков стимулировать продукцию антимикробных пептидов, нормализовать барьерную функцию эпителия, ограничивать бактериальную транслокацию, их применение может быть перспективным в лечении пациентов с заболеваниями поджелудочной железы.

Aim of review. To present the modern concept on the mechanisms of pancreatic disease development and role of intestinal and oral microbiome in pancreatitis pathogenesis. Summary. Intestinal barrier dysfunction, bacterial overgrowth syndrome and endotoxinemia are features of acute pancreatitis. Image-recognition systems (toll-like and NOD-like receptors) and microorganism-associated molecular patterns play important role in these processes. Obtained data indicate the presence of oral and gastrointestinal microbial changes at pancreatic diseases. Subsequently,Helicobacterpyloriinfection may play a role in development of autoimmune pancreatitis and pancreatic cancer,PorphyromonasgingivalisandAggregatibacteractinomycetemcomitans- in pancreatic cancer development. Conclusion. Original study results indicate the presence of oral and bowel microbial changes in pancreatic diseases. Taking into account the ability of probiotics to stimulate production of antimicrobial peptides, normalize epithelial barrier function, limit bacterial translocation, their the application may be promising for pancreatic diseases treatment.

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The authors declare that there are no conflicts of interest present.