gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1563Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL ARTICLESПродолжительность жизни больных и прогностическое значение проявлений и осложнений цирроза печениLifetime of patients and prognostic value of manifestations and complications of liver cirrhosisМироджовГ. К.MirodzhovG. K.АвезовС. А.AvezovS. A.ТухтаеваН. С.TukhtayevaN. S.БахтибековА.BakhtibekovA.ГиясовМ. М.GiyasovM. M.2010021120102052732Copyright © Мироджов Г.К., Авезов С.А., Тухтаева Н.С., Бахтибеков А., Гиясов М.М., 20102010Мироджов Г.К., Авезов С.А., Тухтаева Н.С., Бахтибеков А., Гиясов М.М.Mirodzhov G.K., Avezov S.A., Tukhtayeva N.S., Bakhtibekov A., Giyasov M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1563

Цель исследования. Изучение распространенности цирроза печени (ЦП) в Таджикистане, выживаемости, продолжительности жизни и основных причин смерти больных, а также оценка прогностического значения проявлений и осложнений ЦП.Материал и методы. Обследованы 1374 больных ЦП. Основными этиологическими факторами развития заболевания были: вирус гепатита В, вирус гепатита С, алкоголь.Результаты. Заболеваемость вирусным ЦП в Таджикистане не отличается от показателей в России и некоторых западных странах и составляет 2,32 на 10 000 взрослого населения. Алкогольный ЦП и первичный билиарный цирроз встречаются соответственно более чем в 10 и 5 раз реже. Продолжительность жизни и 3-летняя выживаемость пациентов зависят от степени компенсации цирротического процесса. Наиболее высокая 3-летняя выживаемость пациентов с момента установления диагноза была при ЦП класса А: 79% против 28% при ЦП класса С. У 89% больных причина смерти была непосредственно связана с осложнениями цирроза. Печеночная энцефалопатия и кровотечение служат достоверными критериями прогноза выживаемости больных ЦП. Гепаторенальный синдром, бактериальный перитонит и тромбоз воротной вены также являются независимыми факторами риска летальных исходов.Выводы. Прогноз выживаемости наиболее неблагоприятный при печеночной энцефалопатии по сравнению с другими осложнениями ЦП. Наличие более одного осложнения увеличивает вероятность смерти больных более чем в 2,5 раза. Относительный риск гибели больше у больных с классами В и С по сравнению с классом А.

Aim of investigation

Aim of investigation. Studying of liver cirrhosis (LC) prevalence in Tajikistan, survival rates, lifetimes and principal causes of death of patients, and evaluation of prognostic value of manifestations and complications of LC.

Material and methods

Material and methods. 1374 patients of the LC were investigated. Main etiological factors of development of disease were: hepatitis virus B, hepatitis virus C, alcohol.

 Results

 Results. The incidence of viral LC in Tajikistan does not differ from that in Russia and some western countries and makes 2,32 per 10 000 of adult populations. Alcohol-induced LC and primary biliary cirrhosis are over 10 and 5 times less frequent respectively. Lifetime and 3-year survival rate of patients depend on a phase of cirrhotic process compensation. The highest 3-years survival rate of patients from the moment of establishment of the diagnosis was 79% at class A LC vs 28% at class C LC. At 89% of patients the cause of death has been directly related to complications of cirrhosis. Hepatic encephalopathy and bleeding serve as certain criteria of survival rate prognosis of LC patients. Hepatorenal syndrome, bacterial peritonitis and portal vein thrombosis are independent risk factors of lethal outcomes.

Conclusions

Conclusions. Prognosis of survival is most unfavorable at hepatic encephalopathy in comparison to other complications of the LC. Presence more than one complication increases probability of death of patients more than 2,5 times. The relative risk of death is higher at patients with class B and C in comparison to class A.

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The authors declare that there are no conflicts of interest present.