gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1588Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSБезопасное лечение запоров при беременностиConstipation treatment safety at pregnancyОхлобыстинаО. З.OkhlobystinaO. Z.ГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»Russian Federation2010021220102067075Copyright © Охлобыстина О.З., 20102010Охлобыстина О.З.Okhlobystina O.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1588

Цель обзора. Предоставить данные литературы об особенностях возникновения и лечения запоров при беременности.Основные положения. Беременные женщины, страдающие запорами, употребляют в пищу меньше продуктов, содержащих растительные волокна, и меньше воды. Предполагается, что высокий уровень прогестерона во время беременности приводит к повышенной продукции ренина, нарастающая активность ренин-ангиотензин-альдостероновой системы вызывает повышенную абсорбцию воды в толстой кишке. На поздних сроках беременности толстая кишка оказывается оттеснена и сдавлена увеличенной маткой, что может нарушать продвижение каловых масс и провоцировать запор. Слабительные, содержащие полиэтиленгликоль, рекомендованы как безопасные и предпочтительные для лечения запоров у беременных и кормящих женщин. Макрогол 4000 не метаболизируется и не всасывается, вследствие чего не оказывает вредного влияния на плод.Заключение. Лечение запора во время беременности должно начинаться с немедикаментозных методов. Однако если правильное питание, соблюдение режима и умеренные физические нагрузки не приводят к желаемому результату, возникает необходимость назначения лекарственных препаратов. Макрогол 4000 эффективен и безопасен даже при длительном приеме при беременности.

 

 

The aim of review

The aim of review. To present literature data on development and treatment of constipation at pregnancy.

Original positions

Original positions. Pregnant women, who suffer of constipation, ingest less amount of products, containing plant fibers and less water. It is supposed, that high progesteron level during pregnancy results in increased production of renin, activation of rennin-angiotensinaldosterone system causes increased absorption of water in the large intestine. In late pregnancy the large intestine is pushed aside and compressed by enlarged uterus that can impair passage of fecal masses and provoke constipation. Polyethylene glycol-containing laxatives, are safe and recommended as treatment of choice in constipation at pregnant and breast-feeding women. Macrogol-4000 is not metabolized and not absorbed, having therefore no undesirable effect on fetus.

Conclusion

Conclusion. Treatment of constipation during pregnancy should begin with nonpharmaceutical methods. However, if sure nutrition, keeping of proper lifestyle and moderate physical activity do not result in desirable effect, drugs should be prescribed. Macrogol 4000 is effective and safe at pregnancy even at long-term intake.

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The authors declare that there are no conflicts of interest present.