<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2024-1374-3638</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1599</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Новая техника первично-забрюшинного доступа к верхним брыжеечным сосудам при малоинвазивном хирургическом лечении рака правой половины ободочной кишки с D3-лимфодиссекцией. Методика и первые результаты</article-title><trans-title-group xml:lang="en"><trans-title>Primary Retroperitoneal Approach to the Superior Mesenteric Vessels in Minimally Invasive Surgical Treatment of Right Colon Cancer with D3 Lymph Node Dissection. Technique and First Short-Term Outcomes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0283-2217</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефетов</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Efetov</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефетов Сергей Константинович — кандидат медицинских наук, доцент кафедры факультетской хирургии № 2 им. Г.И. Лукомского, Институт клинической медицины им. Н.В. Склифосовского, заведующий хирургическим отделением № 2 Университетской клинической больницы № 4.</p><p>119048, Москва, ул. Доватора, 15</p></bio><bio xml:lang="en"><p>Sergey K. Efetov — Cand. Sci. (Med.), Associate Professor at the Department of Faculty Surgery No. 2 named after G.I. Lukomsky, N.V. Sklifosovsky Institute of Clinical Medicine, Head of the Surgical Department No. 2 of the University Clinical Hospital No. 4.</p><p>119048, Moscow, Dovatora str., 15</p></bio><email xlink:type="simple">efetov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-0459-2574</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семченко</surname><given-names>Б. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Semchenko</surname><given-names>B. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семченко Богдан Сергеевич — хирург-ординатор кафедры факультетской хирургии № 2 им. Г.И. Лукомского, Институт клинической медицины им. Н.В. Склифосовского.</p><p>119048, Москва, ул. Доватора, 15</p></bio><bio xml:lang="en"><p>Bogdan S. Semchenko — Surgical Resident at the Department of Faculty Surgery No. 2 named after G.I. Lukomsky, N.V. Sklifosovsky Institute of Clinical Medicine.</p><p>119048, Moscow, Dovatora str., 15</p></bio><email xlink:type="simple">bogdansemchenko99@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5809-8948</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рычкова</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Rychkova</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рычкова Арина Кирилловна — хирург-ординатор кафедры факультетской хирургии № 2 им. Г.И. Лукомского, Институт клинической медицины им. Н.В. Склифосовского.</p><p>119048, Москва, ул. Доватора, 15</p></bio><bio xml:lang="en"><p>Arina K. Rychkova — Surgical Resident at the Department of Faculty Surgery No. 2 named after G.I. Lukomsky, N.V. Sklifosovsky Institute of Clinical Medicine.</p><p>119048, Moscow, Dovatora str., 15</p></bio><email xlink:type="simple">ockun.riba@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2024</year></pub-date><volume>34</volume><issue>5</issue><fpage>75</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ефетов С.К., Семченко Б.С., Рычкова А.К., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ефетов С.К., Семченко Б.С., Рычкова А.К.</copyright-holder><copyright-holder xml:lang="en">Efetov S.K., Semchenko B.S., Rychkova A.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1599">https://www.gastro-j.ru/jour/article/view/1599</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: разработать и описать технику первично-забрюшинного доступа к верхним брыжеечным сосудам для выполнения D3-лимфодиссекции при малоинвазивном хирургическом лечении рака правой половины ободочной кишки. Оценить непосредственные результаты первой серии пациентов, оперированных по данной методике.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включены пациенты с аденокарциномой правых отделов ободочной кишки. Разработанная техника первично-забрюшинного доступа заключалась в выполнении мобилизации правых отделов ободочной кишки по задней поверхности в направлении верхних брыжеечных сосудов, D3-лимфодиссекции с пересечением питающих сосудов со стороны забрюшинного пространства с помощью однопортовой системы единого доступа и состояла из последовательного выполнения пяти этапов. На последнем этапе операции лапароскопическим способом выполнялось пересечение брюшины и оставшейся части брыжейки до намеченных границ резекции кишки. Операционный препарат извлекался через отверстие для установки монопорта, после чего формировался анастомоз экстракорпорально. Конечными точками исследования стали непосредственные результаты хирургического лечения.</p></sec><sec><title>Результаты</title><p>Результаты. В исследовании представлены данные первых 5 пациентов с аденокарциномой правых отделов ободочной кишки, которым проведено хирургическое лечение с D3-лимфодиссекцией путем первично-забрюшинного доступа к верхним брыжеечным сосудам. Длительность забрюшинного этапа составила в среднем 110 (90–140) мин. Средняя кровопотеря составила 62 (10–100) мл. Первым двум пациентам было выполнено три этапа забрюшинной части операции. Остальные три пациента были успешно прооперированы первично-забрюшинным доступом с осуществлением всех пяти этапов операции. Число удаленных регионарных лимфоузлов при D3-лимфодиссекции составило в среднем 36 (18–57), апикальных — 6 (4–5), метастатических регионарных — 3 (2–4). У одного пациента развилось осложнение 1-го класса по классификации Клавьена — Диндо, что не потребовало изменения тактики лечения. Средний послеоперационный койко-день составил 8 (5–12) суток.</p></sec><sec><title>Выводы</title><p>Выводы. Впервые описана техника первично-забрюшинного доступа к верхним брыжеечным сосудам для выполнения D3-лимфодиссекции при раке правых отделов ободочной кишки. Полученные результаты продемонстрировали возможность применения данного доступа для малоинвазивного радикального лечения рака правой половины ободочной кишки.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: to develop and describe the technique of primary retroperitoneal approach to the superior mesenteric vessels for D3 lymph node dissection in minimally invasive surgical treatment of the right colon cancer; to evaluate the shortterm results of the first series of patients operated by this technique.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Patients with adenocarcinoma of the right colon were included in the study. The technique of primary retroperitoneal approach consisted in mobilization of the right mesocolon along the posterior surface in the direction of the superior mesenteric vessels, D3 lymph node dissection with crossing of the feeding vessels from the retroperitoneal side using a single-port access system and consisted of five consecutive steps. At the last step of the procedure the peritoneum and the remaining part of the mesentery were crossed laparoscopically to the intended borders of the colon resection. The specimen was extracted through the incision for the single port, followed by the formation of an anastomosis extracorporeally. The endpoints of the study were the short-term results of surgical treatment.</p></sec><sec><title>Results</title><p>Results. The study presents data of the first 5 patients with adenocarcinoma of the right colon who underwent surgical treatment with D3 lymph node dissection using primary retroperitoneal approach to the superior mesenteric vessels. The duration of the retroperitoneal step averaged 110 (90–140) min. The average blood loss was 62 (10–100) mL. The first two patients underwent a three-stage retroperitoneal portion of the surgery. The other three patients were successfully operated by primary retroperitoneal approach with performing of all five steps of the operation. The number of removed regional lymph nodes was on average 36 (18–57), apical lymph nodes — 6 (4–5), metastatic regional lymph nodes — 3 (2–4). One patient developed a Class 1 Clavien — Dindo complication, which did not require a change in treatment tactics. The average postoperative hospital stay was 8 (5–12) days.</p></sec><sec><title>Conclusion</title><p>Conclusion. The technique of primary retroperitoneal approach to the superior mesenteric vessels to perform D3 lymph node dissection was described for the first time. The obtained results demonstrated the possibility of using this method for minimally invasive radical treatment of right colon cancer.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак ободочной кишки</kwd><kwd>лапароскопия</kwd><kwd>первично-забрюшинный доступ</kwd><kwd>D3-лимфодиссекция</kwd><kwd>правосторонняя гемиколэктомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>colorectal cancer</kwd><kwd>laparoscopy</kwd><kwd>retroperitoneal approach</kwd><kwd>right colon</kwd><kwd>D3 lymph node dissection</kwd><kwd>right hemicolectomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34. DOI: 10.3322/caac.21551</mixed-citation><mixed-citation xml:lang="en">Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34. DOI: 10.3322/caac.21551</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs M., Verdeja J.C., Goldstein H.S. Minimally invasive colon resection (laparoscopic colectomy). Surg Laparosc Endosc. 1991;1(3):144–50.</mixed-citation><mixed-citation xml:lang="en">Jacobs M., Verdeja J.C., Goldstein H.S. Minimally invasive colon resection (laparoscopic colectomy). Surg Laparosc Endosc. 1991;1(3):144–50.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Veldkamp R., Kuhry E., Hop W.C., Jeekel J., Kazemier G., Bonjer H.J., et al.; COlon cancer Laparoscop ic or Open Resection Study Group (COLOR). Laparoscopic surgery versus open surgery for colon cancer: Short-term outcomes of a randomised trial. Lancet Oncol. 2005;6(7):477–84. DOI: 10.1016/S1470-2045(05)70221-7</mixed-citation><mixed-citation xml:lang="en">Veldkamp R., Kuhry E., Hop W.C., Jeekel J., Kazemier G., Bonjer H.J., et al.; COlon cancer Laparoscop ic or Open Resection Study Group (COLOR). Laparoscopic surgery versus open surgery for colon cancer: Short-term outcomes of a randomised trial. Lancet Oncol. 2005;6(7):477–84. DOI: 10.1016/S1470-2045(05)70221-7</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hewett P.J., Allardyce R.A., Bagshaw P.F., Frampton C.M., Frizelle F.A., Rieger N.A., et al. Short term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: The ALCCaS tri al. Ann Surg. 2008;248(5):728–38. DOI: 10.1097/SLA.0b013e31818b7595</mixed-citation><mixed-citation xml:lang="en">Hewett P.J., Allardyce R.A., Bagshaw P.F., Frampton C.M., Frizelle F.A., Rieger N.A., et al. Short term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: The ALCCaS tri al. Ann Surg. 2008;248(5):728–38. DOI: 10.1097/SLA.0b013e31818b7595</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bonjer H.J., Hop W.C., Nelson H., Sargent D.J., Lacy A.M., Castells A., et al.; Transatlantic Laparoscopically Assisted vs Open Colectomy Trials Study Group. Laparoscopically assisted vs open colectomy for colon cancer: A meta-analysis. Arch Surg. 2007;142(3):298–303. DOI: 10.1001/archsurg.142.3.298</mixed-citation><mixed-citation xml:lang="en">Bonjer H.J., Hop W.C., Nelson H., Sargent D.J., Lacy A.M., Castells A., et al.; Transatlantic Laparoscopically Assisted vs Open Colectomy Trials Study Group. Laparoscopically assisted vs open colectomy for colon cancer: A meta-analysis. Arch Surg. 2007;142(3):298–303. DOI: 10.1001/archsurg.142.3.298</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jayne D.G., Guillou P.J., Thorpe H., Quirke P., Copeland J., Smith A.M., et al.; UK MRC CLASICC Trial Group. Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol. 2007;25(21):3061– 8. DOI: 10.1200/JCO.2006.09.7758</mixed-citation><mixed-citation xml:lang="en">Jayne D.G., Guillou P.J., Thorpe H., Quirke P., Copeland J., Smith A.M., et al.; UK MRC CLASICC Trial Group. Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol. 2007;25(21):3061– 8. DOI: 10.1200/JCO.2006.09.7758</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Deijen C.L., Vasmel J.E., de Lange-de Klerk E.S.M., Cuesta M.A., Coene P.L.O., Lange J.F., et al.; COLOR (COlon cancer Laparoscopic or Open Resection) study group. Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer. Surg Endosc. 2017;31(6):2607–15. DOI: 10.1007/s00464-016-5270-6</mixed-citation><mixed-citation xml:lang="en">Deijen C.L., Vasmel J.E., de Lange-de Klerk E.S.M., Cuesta M.A., Coene P.L.O., Lange J.F., et al.; COLOR (COlon cancer Laparoscopic or Open Resection) study group. Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer. Surg Endosc. 2017;31(6):2607–15. DOI: 10.1007/s00464-016-5270-6</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ефетов С.К., Зубайраева А.А., Семченко Б.С., Пано ва П.Д., Волгин М.В., Рычкова А.К. Первично-забрюшинный доступ для сосудосберегающей лимфодиссекции в лечении рака левой половины ободочной и прямой кишки — первый российский опыт. Хирургия. Журнал им. Н.И. Пирогова. 2023;(12):26–33. DOI: 10.17116/hirurgia202312126</mixed-citation><mixed-citation xml:lang="en">Efetov S.K., Zubayraeva A.A., Semchenko B.S., Panova P.D., Volgin M.V., Rychkova A.K. Primary retroperitoneal approach for vessel-sparing D3-lymph node dissection in left colonic and rectal cancer resections — the first Russian experience. Pirogov Russian Journal of Surgery. 2023;(12):26–33. (In Russ., In Engl.). DOI: 10.17116/hirurgia202312126</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Efetov S.K., Zubayraeva A.A., Panova P.D. The retroperitoneal approach to vessel-sparing D3 lymph node dissection in left-sided colorectal cancer resections: A video vignette. Colorectal Dis. 2023;25(9):1940–1. DOI: 10.1111/codi.16705</mixed-citation><mixed-citation xml:lang="en">Efetov S.K., Zubayraeva A.A., Panova P.D. The retroperitoneal approach to vessel-sparing D3 lymph node dissection in left-sided colorectal cancer resections: A video vignette. Colorectal Dis. 2023;25(9):1940–1. DOI: 10.1111/codi.16705</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bell S., Kong J.C., Carne P.W.G., Chin M., Simpson P., Farmer C., et al. Oncological safety of laparoscopic versus open colorectal cancer surgery in obesity: A systematic review and meta-analysis. ANZ J Surg. 2019;89(12):1549– 55. DOI: 10.1111/ans.15081</mixed-citation><mixed-citation xml:lang="en">Bell S., Kong J.C., Carne P.W.G., Chin M., Simpson P., Farmer C., et al. Oncological safety of laparoscopic versus open colorectal cancer surgery in obesity: A systematic review and meta-analysis. ANZ J Surg. 2019;89(12):1549– 55. DOI: 10.1111/ans.15081</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kim I.Y., Kim B.R., Kim Y.W. Impact of prior abdominal surgery on rates of conversion to open surgery and shortterm outcomes after laparoscopic surgery for colorectal cancer. PLoS One. 2015;10(7):e0134058. DOI: 10.1371/journal.pone.0134058</mixed-citation><mixed-citation xml:lang="en">Kim I.Y., Kim B.R., Kim Y.W. Impact of prior abdominal surgery on rates of conversion to open surgery and shortterm outcomes after laparoscopic surgery for colorectal cancer. PLoS One. 2015;10(7):e0134058. DOI: 10.1371/journal.pone.0134058</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Franko J., O'Connell B.G., Mehall J.R., Harper S.G., Nejman J.H., Zebley D.M., et al. The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery. JSLS. 2006;10(2):169–75.</mixed-citation><mixed-citation xml:lang="en">Franko J., O'Connell B.G., Mehall J.R., Harper S.G., Nejman J.H., Zebley D.M., et al. The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery. JSLS. 2006;10(2):169–75.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Jakimowicz J., Stultiëns G., Smulders F. Laparoscop ic insufflation of the abdomen reduces portal venous flow. Surg Endosc. 1998;12(2):129–32. DOI: 10.1007/s004649900612</mixed-citation><mixed-citation xml:lang="en">Jakimowicz J., Stultiëns G., Smulders F. Laparoscop ic insufflation of the abdomen reduces portal venous flow. Surg Endosc. 1998;12(2):129–32. DOI: 10.1007/s004649900612</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen N.T., Wolfe B.M. The physiologic effects of pneumoperitoneum in the morbidly obese. Ann Surg. 2005;241(2):219– 26. DOI: 10.1097/01.sla.0000151791.93571.70</mixed-citation><mixed-citation xml:lang="en">Nguyen N.T., Wolfe B.M. The physiologic effects of pneumoperitoneum in the morbidly obese. Ann Surg. 2005;241(2):219– 26. DOI: 10.1097/01.sla.0000151791.93571.70</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zuckerman R.S., Heneghan S. The duration of hemodynamic depression during laparoscopic cholecystectomy. Surg Endosc. 2002;16(8):1233–6. DOI: 10.1007/s00464001-9152-0</mixed-citation><mixed-citation xml:lang="en">Zuckerman R.S., Heneghan S. The duration of hemodynamic depression during laparoscopic cholecystectomy. Surg Endosc. 2002;16(8):1233–6. DOI: 10.1007/s00464001-9152-0</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
