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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2025-35-6-35-41</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-1648</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Камни в желчных протоках после панкреатодуоденальной резекции: причины и лечение</article-title><trans-title-group xml:lang="en"><trans-title>Bile Ducts Stones After Pancreatoduodenal Resection: Risk Factors and Treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6603-1390</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егоров</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егоров Василий Иванович — кандидат медицинских наук, ассистент кафедры онкологии, лучевой диагностики и лучевой терапии; врач-онколог</p><p>420021, г. Казань, ул. Бутлерова, 49 </p></bio><bio xml:lang="en"><p>Vasiliy I. Egorov — Cand. Sci. (Med.), Teaching Assistant of the Department of Oncology, Radiation Therapy; Oncologist</p><p>420000, Kazan, Butlerova str., 49 </p></bio><email xlink:type="simple">drvasiliy21@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Министерства здравоохранения Российской Федерации ; ГАУЗ «Республиканский клинический онкологический диспансер» Министерства здравоохранения Республики Татарстан</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University ; Republican Clinical Oncological Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>23</day><month>02</month><year>2026</year></pub-date><volume>35</volume><issue>6</issue><fpage>35</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Егоров В.И., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Егоров В.И.</copyright-holder><copyright-holder xml:lang="en">Egorov V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/1648">https://www.gastro-j.ru/jour/article/view/1648</self-uri><abstract><p>Панкреатодуоденальная резекция (ПДР) является основным методом хирургического лечения злокачественных новообразований периампулярной зоны. Поздние осложнения после ПДР встречаются в 31,5 % случаев. Наиболее серьезными из них являются стриктуры билиодигестивного анастомоза и образование камней в желчных протоках (билиарные осложнения), частота которых может достигать 10,2 %.</p><p>Цель данного обзора — анализ литературы, посвященной причинам развития билиарных осложнений, включая образование камней в желчных протоках после ПДР, и методам лечения таких пациентов.</p><sec><title>Основные положения</title><p>Основные положения. К предрасполагающим факторам камнеобразования после ПДР относятся застой желчи (вследствие стриктуры анастомоза), остатки шовного материала или клипс, инфекция и рефлюкс кишечного содержимого в желчные протоки. Выбор малоинвазивного метода лечения пациентов с камнями желчных протоков после ПДР зависит от квалификации специалистов и технической оснащенности медицинского учреждения. Эндоскопический доступ характеризуется быстрым достижением клинического успеха и меньшей продолжительностью госпитализации, однако обладает более низкой частотой технического успеха в условиях измененной анатомии. Чрескожный доступ представляет собой высокоэффективный метод малоинвазивного лечения поздних билиарных осложнений, может применяться в качестве первого этапа или у пациентов после неудачного эндоскопического вмешательства. Использование рассасывающегося шовного материала, минимизация количества швов при формировании анастомоза, применение различных вариантов гепатикопластики и предотвращение излишней мобилизации желчного протока могут служить мерами профилактики камнеобразования после панкреатодуоденальной резекции.</p></sec><sec><title>Заключение</title><p>Заключение. Камни желчных протоков как осложнение позднего послеоперационного периода ПДР требуют оказания высококвалифицированной хирургической помощи, в том числе малоинвазивной. Необходимы дальнейшие исследования с целью поиска возможных путей профилактики и совершенствования методов лечения билиарных осложнений ПДР</p></sec></abstract><trans-abstract xml:lang="en"><p>Pancreaticoduodenectomy (PDR) is the primary surgical treatment for periampullary malignancies. Late complications after PDR occur in 31.5 % of cases. The most serious of these are biliary anastomotic strictures and bile duct stone formation (biliary complications), which can occur in up to 10.2 %.</p><sec><title>Aim</title><p>Aim: to analyze the literature concerning the causes of biliary complications, particularly stone formation in the bile ducts after PDR, and the treatment methods for these patients.</p></sec><sec><title>Key points</title><p>Key points. Predisposing factors for stone formation after PDR include bile stasis (due to anastomotic stricture), remnants of suture material or clips, infection, and reflux of intestinal contents into the bile ducts. The choice of a minimally invasive treatment method for patients with bile duct stones after PDR depends on the qualifications of specialists and the technical resources of the medical institution. The endoscopic approach is characterized by rapid clinical success and shorter hospitalization but has a lower technical success rate due to altered anatomy. Percutaneous access is a highly effective minimally invasive treatment for late biliary complications, which can be used as a firstline option or in cases where endoscopic intervention has failed. The use of absorbable suture material, minimizing the number of anastomotic sutures, various hepaticoplasty techniques, and avoiding excessive bile duct mobilization may help prevent stone formation after pancreaticoduodenectomy.</p></sec><sec><title>Conclusion</title><p>Conclusion. Bile duct stones as a complication of the late postoperative period of PDR require highly qualified surgical care, including minimally invasive techniques. Further research is needed to identify possible ways to prevent and improve treatment methods for biliary complications of postpartum biliary reflux.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>панкреатодуоденальная резекция</kwd><kwd>камни желчных протоков</kwd><kwd>холангит</kwd><kwd>стриктуры билиодигестивного анастомоза</kwd><kwd>механическая желтуха</kwd><kwd>рак головки поджелудочной железы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreatoduodenectomy</kwd><kwd>bile duct stones</kwd><kwd>cholangitis</kwd><kwd>biliodigestive anastomosis stricture</kwd><kwd>mechanical jaundice</kwd><kwd>pancreatic head cancer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yoon Y.S., Lee W., Kang C.M., Hong T., Shin S.H., Lee J.W., et al.; for Korean Study Group on Minimally Invasive Pancreatic Surgery (K-MIPS). 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