gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1725Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSЭссенциальные фосфолипиды: старые природные субстанции – новые технологии производства лекарственных препаратовEssential phospholipids: old physical substances – new production technologyУспенскийЮ. П.UspenskyYu. P.2009051020091952428Copyright © Успенский Ю.П., 20092009Успенский Ю.П.Uspensky Y.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1725

Цель обзора. Представление технологических инноваций в производстве новых лекарственных препаратов на основе эссенциальных фосфолипидов (ЭФЛ).Основные положения. Положительное влияние, оказываемое ЭФЛ, известно свыше 100 лет, более 50 лет применяются коммерческие лекарственные препараты на основе ЭФЛ, эффективность которых доказана в многочисленных клинических и экспериментальных исследованиях. Однако традиционно используемые при производстве препаратов технологии обработки субстанций ЭФЛ активным кислородом не оптимальны, поскольку сопровождаются образованием гидроперекисей, обладающих потенциальной токсичностью. Альтернативный способ, применяемый при производстве нового препарата на основе ЭФЛ – Резалют Про, предусматривает обработку фосфолипидных субстанций жидким азотом, что позволяет сохранить полезные свойства природного (нативного) продукта.Заключение. Новая технология, использованная при производстве препарата на основе ЭФЛ Резалют Про, является прогрессивной, способствующей улучшению профиля безопасности и ожидаемого клинического эффекта при применении в клинической практике.

The aim of review

The aim of review. To present technological innovations in production of new drugs on the basis of essential phospholipids (EPL)

Original positions

Original positions. The positive effect of EPL is known for over 100 years. For over 50 years commercial drugs on a basis EPL are applied, their efficacy is proven by numerous clinical and experimental studies. However, traditionally used technologies of treatment of EPL substance by active oxygen at production effecting drugs are not optimal, as they are accompanied by formation of hydroperoxides having potential toxicity. The alternative method used at production of new drug on EPL basis (RESALUT Pro), provides treatment of phospholipid substances by liquid nitrogen that allows to keep beneficial properties of natural (native) product.

Conclusion

Conclusion. The new technology utilised by treatment of agent on EPL basis (RESALUT Pro), is progressive, promoting improvement of safety profile and expected clinical effect.

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The authors declare that there are no conflicts of interest present.