gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1777Research ArticleОБМЕН ОПЫТОМEXCHANG OF EXPERIENCEСовременные принципы лечения запоровModern principles of constipation treatmentЛивзанМ. А.LivzanM. A.2009050320091927074Copyright © Ливзан М.А., 20092009Ливзан М.А.Livzan M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1777

Цель обзора. Представить современные подходы к назначению слабительных препаратов при лечении запоров.Основные положения. Слабительные средства обладают различным механизмом действия. При эпизодически возникающих запорах наиболее эффективны стимулирующие слабительные. Наличие рН­зависимой оболочки, благодаря которой действующее вещество доставляется к толстой кишке, а также предсказуемый по времени наступления эффект и профиль безопасности выделяют дульколакс (бисакодил) среди средств этой группы. При хронических запорах с необходимостью длительной терапии лучшие результаты лечения отмечаются при применении осмотических слабительных, которые в случае резистентных запоров назначаются в сочетании со стимулирующим слабительным.Заключение. Слабительные препараты должны назначаться дифференцированно с учетом различий в механизмах их действия.

The aim of review

The aim of review. To present up-to-date approach to prescription of laxatives at treatment of constipation.

Original positions

Original positions. The laxatives are agents with the various mode of action. At incidentally developing constipation stimulative laxatives are most effective. Presence of рН-dependent coating due to which the active substance is delivered to the large intestine, and also predictive time of the effect onset and safety profile make dulcolax (Bisacodyl) an agent of choice among drugs of this group. At chronic constipation with necessity of prolonged treatment the best results of treatment are obtained at application of osmotic laxatives which in case of resistant constipation are prescribed in combination with stimulative purging.

Conclusion

Conclusion. Laxatives prescription should be differentiated with account of differences in mechanisms of their action.

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The authors declare that there are no conflicts of interest present.