gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2017-27-5-65-68gastro-j-182Research ArticleГЕПАТОЛОГИЯHEPATOLOGYУспешное лечение вирусного гепатита С даклатасвиром и асунапревиром у двух реципиентов донорских легкихEfficacy of daclatasvir and asunaprevir for viral hepatitis С in two donor lung recipientsАбдурахмановД. Т.AbdurakhmanovD. T.abdjamal@mail.ruСидороваЕ. .SidorovaYe. .noemail@neicon.ruТихоновИ. Н.TikhonovI. N.noemail@neicon.ruМухинН. А.MukhinN. A.noemail@neicon.ruИвашкинВ. Т.IvashkinV. T.noemail@neicon.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»РоссияFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityRussian FederationМосковский государственный университет им. М.В. ЛомоносоваРоссияFederal state educational government-financed institution of higher education «Lomonosov Moscow State University»Russian Federation2017120820182756568Copyright © Абдурахманов Д.Т., Сидорова Е..., Тихонов И.Н., Мухин Н.А., Ивашкин В.Т., 20182018Абдурахманов Д.Т., Сидорова Е..., Тихонов И.Н., Мухин Н.А., Ивашкин В.Т.Abdurakhmanov D.T., Sidorova Y..., Tikhonov I.N., Mukhin N.A., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/182

Цель. Оценить эффективность и безопасность терапии гепатита С препаратами прямого противовирусного действия у больных после трансплантации легких. Основные положения. Представлены первые в отечественной литературе и одни из первых в мире наблюдения лечения гепатита С препаратами прямого противовирусного действия у пациентов после трансплантации легких. В результате комбинированной терапии асунапревиром и даклатасвиром в течение 24 нед достигнут устойчивый вирусологический ответ. Клинически значимых нежелательных явлений и межлекарственных взаимодействий, за исключением незначительного и управляемого изменения концентрации такролимуса в крови, не отмечено. Заключение. Комбинацию даклатасвира и асунапревира можно рассматривать как эффективный и безопасный вариант терапии гепатита С у пациентов после трансплантации паренхиматозных органов.

Aim. To estimate efficacy and safety of direct antiviral drugs for hepatitis C treatment in donor lung recipients. Key points. The first cases in Russian literature and one of the first-ever cases of hepatitis C treatment by direct antiviral agents in lung transplant recipients are presented. Combined therapy by asunaprevir and daclatasvir for 24 weeks resulted in sustained virologic response. No significant adverse effects on drug to drug interactions, except for mild and controllable alteration of tacrolimus blood level, were noted. Conclusion. Daclatasvir and asunaprevir combination is effective and safe treatment mode for hepatitis C in donor lung recipients

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The authors declare that there are no conflicts of interest present.