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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2017-27-6-14-19</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-189</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Язвенная болезнь: изменила ли она свое «лицо»?</article-title><trans-title-group xml:lang="en"><trans-title>Peptic ulcer: does it changed identity?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пятенко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pyatenko</surname><given-names>Ye. A.</given-names></name></name-alternatives><email xlink:type="simple">piatenkoe@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шептулин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheptulin</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">arkalshep@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>12</day><month>08</month><year>2018</year></pub-date><volume>27</volume><issue>6</issue><fpage>14</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пятенко Е.А., Шептулин А.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Пятенко Е.А., Шептулин А.А.</copyright-holder><copyright-holder xml:lang="en">Pyatenko Y.A., Sheptulin A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/189">https://www.gastro-j.ru/jour/article/view/189</self-uri><abstract><p>Цель исследования. Оценить возможные изменения эпидемиологических показателей язвенной болезни (ЯБ): пол и возраст больных, возраст больных к моменту начала заболевания, соотношение язв желудка (ЯЖ) и язв двенадцатиперстной кишки (ЯДПК), особенности клинической картины обострений ЯБ, частоту сопутствующих изменений органов пищеварения.  Материал и методы. Методом сплошной выборки были обработаны и проанализированы 79 историй болезни пациентов с ЯБ желудка (ЯБЖ) (16 мужчин и 33 женщины), ЯБ двенадцатиперстной кишки (ЯБДПК) (15 мужчин и 9 женщин) и ЯБ сочетанной локализации (1 мужчина и 5 женщин). Раздельно в группах мужчин и женщин оценивали частоту выявления клинических симптомов обострения ЯБ и сопутствующих изменений.  Результаты. В настоящее время отмечаются сдвиг соотношения ЯЖ и ЯДПК в сторону язв желудочной локализации, увеличение доли женщин среди больных с ЯБ, а также среднего возраста пациентов к моменту начала заболевания. Боли в подложечной области, возникающие натощак или после приема пищи, остаются ведущим симптомом обострения ЯБ, который наблюдается у 87,5% мужчин и 95,7% женщин. Значительный процент пациентов, у которых возникают изжога и отрыжка, объясняется высокой частотой сочетания ЯБ с гастроэзофагеальной  рефлюксной   болезнью   (ГЭРБ) (у 93,8% мужчин и 83,0% женщин). Положительные результаты теста на наличие инфекции Helicobacter pylori (H. pylori) были получены у 94,9% больных. Идиопатическиe H. pylori-отрицательные язвы были выявлены лишь у 5,1% пациентов.  Выводы. Современное течение ЯБ характеризуется изменением привычного соотношения мужчин и женщин среди больных, а также ЯЖ и ЯДПК, высокой частотой сочетания ЯБ с ГЭРБ. У большинства больных с ЯБ в период обострения выявляют инфекцию H. pylori.</p></abstract><trans-abstract xml:lang="en"><p>Aim of investigation. To estimate possible changes of peptic ulcer (PU) epidemiology: gender and age of patients, age at disease onset, ratio of the stomach ulcers (SU) to duodenal ulcers (DU), clinical features at relapse of PU, frequency of concomitant digestive diseases. Material and methods. Overall 79 case records of patients with PUD of the stomach (PUS) (16 men, 33 women), PUD of duodenum (PUD) (15 men, 9 women) and PUD of combined localization (1 man and 5 women) were included in the study by continuous sampling method. Symptom frequency at PUD relapse and accompanying changes was estimated independently for male and female groups. Results. At the present time there is a shift of PUS to PUD ratio towards more common stomach ulcer location, increase in female proportion of PU patients and mean patient age at the onset of disease. Epigastric pain that develop in fasting state or after food intake remains to be the leading symptom of PU relapse and is observed at 87.5% of male and 95.7% of female patients. Significant number of patients present with heartburn and belching, that is explained by high frequency of PU to gastroesophageal reflux disease (GERD) combination (in 93.8% of men and 83.0% of women). Positive test for Helicobacter pylori (H. pylori) infection were received in 94.9% of patients. Idiopathic H. pylori-negative ulcers were detected only in 5.1% of patients. Conclusions. The modern trend in the PU clinical course is characterized by shift of typical male to female ratio, as well as PUD to PUS ratio, the high frequency of PU to GERD combination. Most patients were admitted for relapse of PU were positive for H. pylori infection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>язвенная болезнь желудка</kwd><kwd>язвенная болезнь двенадцатиперстной кишки</kwd><kwd>Helicobacter pylori</kwd><kwd>язвенная болезнь желудка</kwd><kwd>язвенная болезнь двенадцатиперстной кишки</kwd><kwd>Helicobacter pylori</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Шептулин А.А., Маев И.В. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению язвенной болезни. Рос журн гастроэнтерол гепатол колопроктол 2016; 26(6):40-54 [Ivashkin V.T., Sheptulin A.A., Mayev I.V. et al. Diagnosis and treatment of peptic ulcer disease: clinical guidelines of the Russian gastroenterological association. 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