<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2017-27-6-96-108</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-197</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФОРМАЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFORMATION</subject></subj-group></article-categories><title-group><article-title>Резолюция Экспертного совета «Современный взгляд на проблему постхолецистэктомического синдрома»</article-title><trans-title-group xml:lang="en"><trans-title>Postcholecystectomy syndrome: the modern approach: resolution of Advisory council</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Охлобыстин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Okhlobystin</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">pancreat_guidelines@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бордин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bordin</surname><given-names>D. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селезнева</surname><given-names>Э. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Seleznyova</surname><given-names>E. Ya.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кучерявый</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kucheryavy</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быстровская</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bystrovskaya</surname><given-names>Ye. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васнев</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasnev</surname><given-names>O. C.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипенко</surname><given-names>М. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipenko</surname><given-names>M. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мусаев</surname><given-names>Г. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Musayev</surname><given-names>G. H.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шульпекова</surname><given-names>Ю. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Shulpekova</surname><given-names>Yu. O.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Московский клинический научный центр им. А.С. Логинова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State government-financed healthcare institution of the Moscow Health Department «Loginov Moscow Clinical Scientific Center»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Московский государственный медико-стоматологический университет им.А.И. Евдокимова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Novosibirsk state medical university»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>12</day><month>08</month><year>2018</year></pub-date><volume>27</volume><issue>6</issue><fpage>96</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Охлобыстин А.В., Бордин Д.С., Селезнева Э.Я., Кучерявый Ю.А., Быстровская Е.В., Васнев О.С., Осипенко М.Ф., Мусаев Г.Х., Шульпекова Ю.О., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Охлобыстин А.В., Бордин Д.С., Селезнева Э.Я., Кучерявый Ю.А., Быстровская Е.В., Васнев О.С., Осипенко М.Ф., Мусаев Г.Х., Шульпекова Ю.О.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Okhlobystin A.V., Bordin D.S., Seleznyova E.Y., Kucheryavy Y.A., Bystrovskaya Y.V., Vasnev O.C., Osipenko M.F., Musayev G.H., Shulpekova Y.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/197">https://www.gastro-j.ru/jour/article/view/197</self-uri><abstract><p>Цель публикации. Представить материалы Экспертного совета, который состоялся 25 августа 2017 г. в Праге (Чехия) при поддержке компании «Adamed Group». Основные положения. В ходе работы Экспертного совета был предложен алгоритм обследования и лечения пациентов с постхолецистэктомическим синдромом (ПХЭС). Желчнокаменную болезнь (ЖБК) выявляют у 10-25% населения различного возраста, в настоящее время отмечается четкая тенденция к расширению возрастного диапазона в сторону «омоложения». Количество больных с ЖКБ каждое десятилетие увеличивается как минимум вдвое. Основным методом хирургического лечения ЖКБ, протекающей с клинической симптоматикой, остается холецистэктомия. В последние два десятилетия повсеместное распространение и статус «стандарта» хирургического лечения получила лапароскопическая холецистэктомия. В то же время при бессимптомном течении наиболее целесообразно придерживаться тактики наблюдения за пациентом без активного лечения. Билиарный сладж и микролитиаз, в том числе не диагностированный при рутинном обследовании, могут быть одними из важных факторов развития ПХЭС. Медикаментозная коррекция расстройств функции сфинктера Одди на фоне ЖКБ/ПХЭС должная включать соблюдение диеты, прием селективных спазмолитиков, пищеварительных ферментов, препаратов урсодезоксихолевой кислоты. Выводы. После холецистэктомии показано динамическое наблюдение за пациентами, при появлении/усилении клинической симптоматики - комплексное обследование для исключения хирургического генеза ПХЭС и сопутствующих заболеваний. Лечение должно включать курсовую терапию селективными спазмолитическими препаратами, по показаниям - назначение препаратов желчных кислот, в отдельных случаях - применение методов эндоскопической хирургии.</p></abstract><trans-abstract xml:lang="en"><p>Aim of publication. To present proceedings of Advisory council on postcholecystectomy syndrome (August 25, 2017; Prague, Czech Republic) with support of the Adamed Group company. Summary. The Advisory council proposed algorithm for investigation and management of patients with postcholecystectomy syndrome (PCS). Gallstone disease (GSD) is diagnosed in 10-25% of the population of various age, with obvious trend to involvement of the younger patient categories in the last decades. The total number of GSD patients increases every decade no less than twice. Cholecystectomy remains the basic method of surgical treatment of symptomatic GSD. Nowadays laparoscopic cholecystectomy became universally popular and earned the status of the «gold standard» of surgical treatment. At the same time at asymptomatic GSD the watchful waiting approach avoiding active treatment is considered to be the most expedient. Biliary sludge and microlithiasis including cases undiagnosed at routine investigation can be one of important factors for development of the PCS. Pharmacological treatment of sphincter of Oddi dysfunction that develop at GSD/PCS include following of dietary recommendations, intake of selective spasmolytics, digestive enzymes and ursodeoxycholic acid.  Conclusions. Follow-up program for the patient of the cholecystectomy should include regular assessment of clinical symptoms for duly diagnostics of acute and/or severe complications and associated diseases, that may require surgical treatment. Treatment has to include regular courses of selective antispasmodics, the presence of indications - prescription of bile acid supplements, when required - methods of endoscopic surgery.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>постхолецистэктомический синдром</kwd><kwd>желчнокаменная болезнь</kwd><kwd>селективные спазмолитики</kwd><kwd>препараты желчных кислот</kwd><kwd>эндоскопическая хирургия</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Лапина Т.Л., Баранская Е.К., Буеверов А.О., Буклис Э.Р., Гуревич К.Г. Рациональная фармакотерапия органов пищеварения: Руководство для практикующих врачей. М.: Литтерра; 2003. 1046 с.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В.Т., Лапина Т.Л., Баранская Е.К., Буеверов А.О., Буклис Э.Р., Гуревич К.Г. Рациональная фармакотерапия органов пищеварения: Руководство для практикующих врачей. М.: Литтерра; 2003. 1046 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Slattery S.A., Niaz O., Aziz Q., Ford A.C., Farmer A.D. Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther 2015;42(1):3-11. DOI:10.1111/apt.13227.</mixed-citation><mixed-citation xml:lang="en">Slattery S.A., Niaz O., Aziz Q., Ford A.C., Farmer A.D. Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther 2015;42(1):3-11. DOI:10.1111/apt.13227.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Abeysuriya V., Deen K.I., Navarathne N.M. Biliary microlithiasis, sludge, crystals, microcrystallization, and usefulness of assessment of nucleation time. Hepatobiliary Pancreat Dis Int 2010;9(3):248-53. http://www.ncbi. nlm.nih.gov/pubmed/20525550.</mixed-citation><mixed-citation xml:lang="en">Abeysuriya V., Deen K.I., Navarathne N.M. Biliary microlithiasis, sludge, crystals, microcrystallization, and usefulness of assessment of nucleation time. Hepatobiliary Pancreat Dis Int 2010;9(3):248-53. http://www.ncbi. nlm.nih.gov/pubmed/20525550.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Takeda S., Aburada M. The choleretic mechanism of coumarin compounds and phenolic compounds. J pharmacobio-dynamics 1981;4(9):724-34. http://www. ncbi.nlm.nih.gov/pubmed/7334456.</mixed-citation><mixed-citation xml:lang="en">Takeda S., Aburada M. The choleretic mechanism of coumarin compounds and phenolic compounds. J pharmacobio-dynamics 1981;4(9):724-34. http://www. ncbi.nlm.nih.gov/pubmed/7334456.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pickuth D., Spielmann R.P. Detection of choledocholithiasis: comparison of unenhanced spiral CT, US, and ERCP. Hepato-gastroenterology 2000;47(36):1514-7. http://www.ncbi.nlm.nih.gov/ pubmed/11148990.</mixed-citation><mixed-citation xml:lang="en">Pickuth D., Spielmann R.P. Detection of choledocholithiasis: comparison of unenhanced spiral CT, US, and ERCP. Hepato-gastroenterology 2000;47(36):1514-7. http://www.ncbi.nlm.nih.gov/ pubmed/11148990.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Шевченко В.П. Питание при болезнях органов пищеварения. Военно-мед журн 2006;327(1):54.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В.Т., Шевченко В.П. Питание при болезнях органов пищеварения. Военно-мед журн 2006;327(1):54.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Stiehl A., Raedsch R., Czygan P., Gotz R., Manner C., Walker S. et al. Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 1980;79(6):1192-8. http://www.ncbi. nlm.nih.gov/pubmed/7439628.</mixed-citation><mixed-citation xml:lang="en">Stiehl A., Raedsch R., Czygan P., Gotz R., Manner C., Walker S. et al. Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 1980;79(6):1192-8. http://www.ncbi. nlm.nih.gov/pubmed/7439628.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sandblom G., Videhult P., Crona Guterstam Y., Svenner A., Sadr-Azodi O. Mortality after a cholecystectomy: a population-based study. HPB: the official journal of the International Hepato Pancreato Biliary Association 2015;17(3):239-43. DOI:10.1111/ hpb.12356.</mixed-citation><mixed-citation xml:lang="en">Sandblom G., Videhult P., Crona Guterstam Y., Svenner A., Sadr-Azodi O. Mortality after a cholecystectomy: a population-based study. HPB: the official journal of the International Hepato Pancreato Biliary Association 2015;17(3):239-43. DOI:10.1111/ hpb.12356.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Agresta F., Campanile F.C., Vettoretto N., Silecchia G., Bergamini C., Maida P. et al. Laparoscopic cholecystectomy: consensus conference-based guidelines. Langenbeck’s archives of surgery. Dtsch Gesellschaft Chir 2015;400(4):429-53. DOI:10.1007/s00423-015-1300-4.</mixed-citation><mixed-citation xml:lang="en">Agresta F., Campanile F.C., Vettoretto N., Silecchia G., Bergamini C., Maida P. et al. Laparoscopic cholecystectomy: consensus conference-based guidelines. Langenbeck’s archives of surgery. Dtsch Gesellschaft Chir 2015;400(4):429-53. DOI:10.1007/s00423-015-1300-4.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Finan K.R., Leeth R.R., Whitley B.M., Klapow J.C., Hawn M.T. Improvement in gastrointestinal symptoms and quality of life after cholecystectomy. Am J Surg 2006; 192(2):196-202. DOI:10.1016/j.amjsurg.2006.01.020.</mixed-citation><mixed-citation xml:lang="en">Finan K.R., Leeth R.R., Whitley B.M., Klapow J.C., Hawn M.T. Improvement in gastrointestinal symptoms and quality of life after cholecystectomy. Am J Surg 2006; 192(2):196-202. DOI:10.1016/j.amjsurg.2006.01.020.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lien H.H., Huang C.C., Wang P.C., Huang C.S., Chen Y.H., Lin T.L. et al. Changes in quality-of-life following laparoscopic cholecystectomy in adult patients with cholelithiasis. J Gastrointestinal Surg: official journal of the Society for Surgery of the Alimentary Tract 2010;14(1):126-30. DOI:10.1007/s11605-009-1062-9.</mixed-citation><mixed-citation xml:lang="en">Lien H.H., Huang C.C., Wang P.C., Huang C.S., Chen Y.H., Lin T.L. et al. Changes in quality-of-life following laparoscopic cholecystectomy in adult patients with cholelithiasis. J Gastrointestinal Surg: official journal of the Society for Surgery of the Alimentary Tract 2010;14(1):126-30. DOI:10.1007/s11605-009-1062-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shi H.Y., Lee H.H., Tsai M.H., Chiu C.C., Uen Y.H., Lee K.T. Long-term outcomes of laparoscopic cholecystectomy: a prospective piecewise linear regression analysis. Surg Endosc 2011;25(7):2132-40. DOI:10.1007/ s00464-010-1508-x.</mixed-citation><mixed-citation xml:lang="en">Shi H.Y., Lee H.H., Tsai M.H., Chiu C.C., Uen Y.H., Lee K.T. Long-term outcomes of laparoscopic cholecystectomy: a prospective piecewise linear regression analysis. Surg Endosc 2011;25(7):2132-40. DOI:10.1007/ s00464-010-1508-x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Moazeni-Bistgani M., Imani R. Bile bacteria of patients with cholelithiasis and theirs antibiogram. Acta medica Iranica 2013;51(11):779-83. http://www.ncbi.nlm.nih. gov/pubmed/24390947.</mixed-citation><mixed-citation xml:lang="en">Moazeni-Bistgani M., Imani R. Bile bacteria of patients with cholelithiasis and theirs antibiogram. Acta medica Iranica 2013;51(11):779-83. http://www.ncbi.nlm.nih. gov/pubmed/24390947.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ito K., Ito H., Whang E.E. Timing of cholecystectomy for biliary pancreatitis: do the data support current guidelines? J Gastrointestinal Surg: official journal of the Society for Surgery of the Alimentary Tract 2008;12(12):2164-70. DOI:10.1007/s11605-008-0603-y.</mixed-citation><mixed-citation xml:lang="en">Ito K., Ito H., Whang E.E. Timing of cholecystectomy for biliary pancreatitis: do the data support current guidelines? J Gastrointestinal Surg: official journal of the Society for Surgery of the Alimentary Tract 2008;12(12):2164-70. DOI:10.1007/s11605-008-0603-y.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher M., Spilias D.C., Tong L.K. Diarrhoea after laparoscopic cholecystectomy: incidence and main determinants. ANZ J Surg 2008;78(6):482-6. DOI:10.1111/j.1445-2197.2008.04539.x.</mixed-citation><mixed-citation xml:lang="en">Fisher M., Spilias D.C., Tong L.K. Diarrhoea after laparoscopic cholecystectomy: incidence and main determinants. ANZ J Surg 2008;78(6):482-6. DOI:10.1111/j.1445-2197.2008.04539.x.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Venneman N.G., Besselink M.G., Keulemans Y.C., Vanberge-Henegouwen G.P., Boermeester M.A., Broeders I.A. et al. Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy. Hepatology 2006;43(6):127683. DOI:10.1002/hep.21182.</mixed-citation><mixed-citation xml:lang="en">Venneman N.G., Besselink M.G., Keulemans Y.C., Vanberge-Henegouwen G.P., Boermeester M.A., Broeders I.A. et al. Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy. Hepatology 2006;43(6):127683. DOI:10.1002/hep.21182.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cotton P.B., Elta G.H., Carter C.R., Pasricha P.J., Corazziari E.S. Rome I.V. Gallbladder and Sphincter of Oddi Disorders. Gastroenterology 2016. DOI:10.1053/j. gastro.2016.02.033.</mixed-citation><mixed-citation xml:lang="en">Cotton P.B., Elta G.H., Carter C.R., Pasricha P.J., Corazziari E.S. Rome I.V. Gallbladder and Sphincter of Oddi Disorders. Gastroenterology 2016. DOI:10.1053/j. gastro.2016.02.033.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Yap L., Wycherley A.G., Morphett A.D., Toouli J. Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology 1991;101(3):786-93. http://www.ncbi. nlm.nih.gov/pubmed/1860640.</mixed-citation><mixed-citation xml:lang="en">Yap L., Wycherley A.G., Morphett A.D., Toouli J. Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology 1991;101(3):786-93. http://www.ncbi. nlm.nih.gov/pubmed/1860640.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cotton P.B., Pauls Q., Keith J., Thornhill A., Drossman D., Williams A. et al. The EPISOD study: long-term outcomes. Gastrointestinal Endoscopy 2017. DOI:10.1016/j.gie.2017.04.015.</mixed-citation><mixed-citation xml:lang="en">Cotton P.B., Pauls Q., Keith J., Thornhill A., Drossman D., Williams A. et al. The EPISOD study: long-term outcomes. Gastrointestinal Endoscopy 2017. DOI:10.1016/j.gie.2017.04.015.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bagaria D., Kaman L., Roger E., Dahyia D., Singh R., Bhattacharya A. Effect of laparoscopic cholecystectomy on gastric emptying and dyspepsia. Surg Endoscopy 2013;27(9):3116-20. DOI:10.1007/s00464-013-2838-2.</mixed-citation><mixed-citation xml:lang="en">Bagaria D., Kaman L., Roger E., Dahyia D., Singh R., Bhattacharya A. Effect of laparoscopic cholecystectomy on gastric emptying and dyspepsia. Surg Endoscopy 2013;27(9):3116-20. DOI:10.1007/s00464-013-2838-2.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Shah Gilani S.N., Bass G.A., Kharytaniuk N., Downes M.R., Caffrey E.F., Tobbia I. et al. Gastroesophageal Mucosal Injury after Cholecystectomy: An Indication for Surveillance? J Am College Surg 2017;224(3):319-26. DOI:10.1016/j. jamcollsurg.2016.12.003.</mixed-citation><mixed-citation xml:lang="en">Shah Gilani S.N., Bass G.A., Kharytaniuk N., Downes M.R., Caffrey E.F., Tobbia I. et al. Gastroesophageal Mucosal Injury after Cholecystectomy: An Indication for Surveillance? J Am College Surg 2017;224(3):319-26. DOI:10.1016/j. jamcollsurg.2016.12.003.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J., Lu Q., Ren Y.F., Dong J., Mu Y.P., Lv Y. et al. Factors relevant to persistent upper abdominal pain after cholecystectomy. HPB: the official journal of the International Hepato Pancreato Biliary Association 2017;19(7):629-37. DOI:10.1016/j.hpb.2017.04.003.</mixed-citation><mixed-citation xml:lang="en">Zhang J., Lu Q., Ren Y.F., Dong J., Mu Y.P., Lv Y. et al. Factors relevant to persistent upper abdominal pain after cholecystectomy. HPB: the official journal of the International Hepato Pancreato Biliary Association 2017;19(7):629-37. DOI:10.1016/j.hpb.2017.04.003.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kirk G., Kennedy R., McKie L., Diamond T., Clements B. Preoperative symptoms of irritable bowel syndrome predict poor outcome after laparoscopic cholecystectomy. Surg Endosc 2011;25(10):3379-84. DOI:10.1007/s00464-011-1729-7.</mixed-citation><mixed-citation xml:lang="en">Kirk G., Kennedy R., McKie L., Diamond T., Clements B. Preoperative symptoms of irritable bowel syndrome predict poor outcome after laparoscopic cholecystectomy. Surg Endosc 2011;25(10):3379-84. DOI:10.1007/s00464-011-1729-7.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mertens M.C., De Vries J., Scholtes V.P., Jansen P., Roukema J.A. Prospective 6 weeks follow-up postcholecystectomy: the predictive value of pre-operative symptoms. J Gastrointestinal Surg: official journal of the Society for Surgery of the Alimentary Tract 2009;13(2):304-11. DOI:10.1007/s11605-008-0718-1.</mixed-citation><mixed-citation xml:lang="en">Mertens M.C., De Vries J., Scholtes V.P., Jansen P., Roukema J.A. Prospective 6 weeks follow-up postcholecystectomy: the predictive value of pre-operative symptoms. J Gastrointestinal Surg: official journal of the Society for Surgery of the Alimentary Tract 2009;13(2):304-11. DOI:10.1007/s11605-008-0718-1.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Thistle J.L., Longstreth G.F., Romero Y., Arora A.S., Simonson J.A., Diehl N.N., et al. Factors that predict relief from upper abdominal pain after cholecystectomy. Clin gastroenterol hepatol: the official clinical practice journal of the American Gastroenterological Association 2011;9(10):891-6. DOI:10.1016/j.cgh.2011.05.014.</mixed-citation><mixed-citation xml:lang="en">Thistle J.L., Longstreth G.F., Romero Y., Arora A.S., Simonson J.A., Diehl N.N., et al. Factors that predict relief from upper abdominal pain after cholecystectomy. Clin gastroenterol hepatol: the official clinical practice journal of the American Gastroenterological Association 2011;9(10):891-6. DOI:10.1016/j.cgh.2011.05.014.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Roumm A.R., Pizzi L., Goldfarb N.I., Cohn H. Minimally invasive: minimally reimbursed? An examination of six laparoscopic surgical procedures. Surg Innovation 2005;12(3):261-87. DOI:10.1177/155335060501200313.</mixed-citation><mixed-citation xml:lang="en">Roumm A.R., Pizzi L., Goldfarb N.I., Cohn H. Minimally invasive: minimally reimbursed? An examination of six laparoscopic surgical procedures. Surg Innovation 2005;12(3):261-87. DOI:10.1177/155335060501200313.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman L.S., Kaneva P., Demyttenaere S., Carli F., Fried G.M., Mayo N.E. Validation of a physical activity questionnaire (CHAMPS) as an indicator of postoperative recovery after laparoscopic cholecystectomy. Surgery 2009;146(1):31-9. DOI:10.1016/j.surg.2009.02.019.</mixed-citation><mixed-citation xml:lang="en">Feldman L.S., Kaneva P., Demyttenaere S., Carli F., Fried G.M., Mayo N.E. Validation of a physical activity questionnaire (CHAMPS) as an indicator of postoperative recovery after laparoscopic cholecystectomy. Surgery 2009;146(1):31-9. DOI:10.1016/j.surg.2009.02.019.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wedlake L., A’Hern R., Russell D., Thomas K., Walters J.R., Andreyev H.J. Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2009;30(7):707-17. DOI:10.1111/j.13652036.2009.04081.x.</mixed-citation><mixed-citation xml:lang="en">Wedlake L., A’Hern R., Russell D., Thomas K., Walters J.R., Andreyev H.J. Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2009;30(7):707-17. DOI:10.1111/j.13652036.2009.04081.x.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Sung H.J., Paik C.N., Chung W.C., Lee K.M., Yang J.M., Choi M.G. Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients. J Neurogastroenterol Motil 2015;21(4):545-51. DOI:10.5056/jnm15020.</mixed-citation><mixed-citation xml:lang="en">Sung H.J., Paik C.N., Chung W.C., Lee K.M., Yang J.M., Choi M.G. Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients. J Neurogastroenterol Motil 2015;21(4):545-51. DOI:10.5056/jnm15020.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Wanjura V., Sandblom G. How Do Quality-of-Life and Gastrointestinal Symptoms Differ Between Postcholecystectomy Patients and the Background Population? World J Surg 2016;40(1):81-8. DOI:10.1007/s00268-0153240-0.</mixed-citation><mixed-citation xml:lang="en">Wanjura V., Sandblom G. How Do Quality-of-Life and Gastrointestinal Symptoms Differ Between Postcholecystectomy Patients and the Background Population? World J Surg 2016;40(1):81-8. DOI:10.1007/s00268-0153240-0.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wei J.G., Wang Y.C., Liang G.M., Wang W., Chen B.Y., Xu J.K. et al. The study between the dynamics and the X-ray anatomy and regularizing effect of gallb.ladder on bile duct sphincter of the dog. World J Gastroenterol: WJG 2003;9(5):1014-9. http://www.ncbi. nlm.nih.gov/pubmed/12717848.</mixed-citation><mixed-citation xml:lang="en">Wei J.G., Wang Y.C., Liang G.M., Wang W., Chen B.Y., Xu J.K. et al. The study between the dynamics and the X-ray anatomy and regularizing effect of gallb.ladder on bile duct sphincter of the dog. World J Gastroenterol: WJG 2003;9(5):1014-9. http://www.ncbi. nlm.nih.gov/pubmed/12717848.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
