gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1976Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSВозможное участие бактерий рода Helicobacter в патогенезе гепатобилиарных заболеванийPossible involvement of Helicobacter spp. bacteria in pathogenesis of hepatobiliary diseasesИсаеваГ. Ш.IsayevaG. Sh.2008250820081841422Copyright © Исаева Г.Ш., 20082008Исаева Г.Ш.Isayeva G.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1976

Цель обзора. Представить анализ данных литературы о возможном участии бактерий рода Helicobacter в патогенезе заболеваний гепатобилиарной системы.Последние данные литературы. В ходе научных исследований, проведенных в последнее время, бактерии выявлены в желчи, тканях печени, слизистой оболочке желчного пузыря и желчных протоков, что свидетельствует о их способности колонизировать органы гепатобилиарной системы. На существование возможной связи бактерий рода Helicobacter с развитием хронического холецистита, желчнокаменной болезни, холангио-­ и гепатокарциномы указывают многочисленные исследования с использованием молекулярных, гистологических, микроскопических, бактериологических, иммунологических методов, опыты на биологических моделях. Расшифровка патогенетических механизмов с участием этих микроорганизмов открывает перспективу применения антигеликобактерной терапии для лечения и профилактики заболеваний гепатобилиарной системы.Заключение. Накопленные сведения о роли H. pylori и других видов рода Helicobacter в развитии патологии печени, желчного пузыря и желчевыводящих путей позволяют сделать первоначальные выводы о их возможном участии в этих процессах. Несмотря на противоречивость мнений, это новое быстро развивающееся направление можно отнести к весьма перспективному и требующему продолжения исследований в данной области.

The aim of review

The aim of review. To present analysis of literature data on possible participation of Helicobacter species in pathogenesis of diseases of hepatobiliary system.

Recent literature data

Recent literature data. During recent studies, bacteria were revealed in bile, liver tissue, mucosa of the gallbladder and bile ducts that proves ability of Helicobacters to colonize hepatobiliary organs. Multiple investigations with application of molecular, histological, microscopic, bacteriological, immunologic methods, biological models experiments indicate the possible relation of Helicobacter spp. to development of chronic cholecystitis, cholelithiasis, cholangio- and hepatocarcinoma. Decoding of pathogenic mechanisms involving these microorganisms opens prospects for application of antihelicobacter therapy in treatment and prophylaxes of hepatobiliary diseases.

Conclusion

Conclusion. Cumulative data on the role of H. pylori and other species of Helicobacter genus in development of liver, gallbladder and biliary diseases allow to draw initial conclusions on their probable involvement in these processes. Despite equivocal opinions, this new rapidly educing trend may be rather perspective and require further studies in this area.

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The authors declare that there are no conflicts of interest present.