gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLCgastro-j-1990Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSАллельный полиморфизм интерлейкина-1β при геликобактериозеInterleukin-1b allelic polymorphism at H. pylori infectionМаевИ. В.MayevI. V.КучерявыйЮ. А.KucheryavyYu. A.ОганесянТ. С.OganesyanT. S.200826092008185411Copyright © Маев И.В., Кучерявый Ю.А., Оганесян Т.С., 20082008Маев И.В., Кучерявый Ю.А., Оганесян Т.С.Mayev I.V., Kucheryavy Y.A., Oganesyan T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/1990

Цель обзора. Проанализировать данные литературы о роли, оказываемой полиморфизмом генов интерлейкина­-1β на развитие и течение геликобактериоза.Последние данные литературы. В настоящее время ключевым вопросом геликобактериоза является возможность инфекции H. pylori индуцировать такие разные заболевания, как язвенная болезнь двенадцатиперстной кишки и рак желудка. Основой патогенеза геликобактериоза является воспаление слизистой оболочки желудка. В развитии любого воспалительного процесса, а также в его исходе важную (если не главную) роль играет равновесие продукции, экспрессии и ингибиции синтеза белков семейства интерлейкина­-1. Сегодня доказано, что различный уровень выработки интерлейкина-­1 связан с наличием определенных аллелей.Заключение. Полиморфизм генов семейства интерлейкина-­1 оказывает существенное влияние на течение, исход и в конечном итоге на лечение инфекции Helicobacter pylori.

The aim of review

The aim of review. To analyze literature data on the role of genetic polymorphism of interleukin-1b in development and course of H. pylori infection.

Recent literature data

Recent literature data. Now a key question of H. pylori infection is the potential of the microorganism to induce such diverse diseases, as duodenal peptic ulcer and stomach cancer. A basis of H. pylori infection pathogenesis is inflammation of the stomach mucosa. In development of any inflammatory process, and also in its outcome the balance of production, expression and inhibition of synthesis of interleukin-1 protein family plays important (if not the main) role. Today it is proved, that the various levels of interleukin-1 production are related to the presence of certain alleles.

Conclusion

Conclusion. Genetic polymorphism of interleukin-1 family has essential effect on course, outcomes and finally on the treatment of Helicobacter pylori infection.

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The authors declare that there are no conflicts of interest present.