gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2018-28-2-4-10gastro-j-224Research ArticleОБЗОРЫREVIEWSМетаболизм желчных кислот, заболевания печени и микробиомMetabolism of bile acids, liver diseases and microbiomeЕвсютинаЮ. В.YevsyutinaYu. V.noemail@neicon.ruИвашкинВ. Т.IvashkinV. T.noemail@neicon.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет); ФГБУ «Национальный медицинский исследовательский центр профилактической медицины»РоссияNational Research Center for Preventive MedicineRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation201812082018282410Copyright © Евсютина Ю.В., Ивашкин В.Т., 20182018Евсютина Ю.В., Ивашкин В.Т.Yevsyutina Y.V., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/224

Цель обзора. Представить современные данные о взаимосвязи метаболизма желчных кислот (ЖК), микробиома и заболеваний печени. Основные положения. ЖК - важные сигнальные молекулы, регулирующие метаболизм липидов и глюкозы. Энтерогепатическая циркуляция ЖК занимает центральное место в абсорбции нутриентов и их метаболической регуляции. Результаты исследований свидетельствуют о взаимосвязи ЖК, кишечного микробиома и заболеваний печени. В частности, хорошо изучена роль нарушения метаболизма ЖК в развитии неалкогольной жировой болезни печени. Практический интерес представляют секвестранты ЖК, которые продолжают изучать как регуляторы метаболизма ЖК и глюкозы. Заключение. ЖК выполняют разнообразные функции в организме. Результаты многочисленных работ демонстрируют тесную связь между метаболизмом ЖК, патологией печени и кишечным микробиомом.

Aim of review. To present the modern data on interrelation of bile acid (BA) metabolism, microbiome and liver diseases. Summary. Bile acids are important signaling molecules that regulate lipid and glucose metabolism. Enterohepatic circulation of BA plays the central role in nutrient absorption and metabolic regulation. Data of investigations demonstrate interrelation of BA, intestinal microbiome and liver diseases. In particular, the role of BA metabolism disorders in development of non-alcoholic fatty liver disease is extensively studied. Sequestrants of BA are under study as putative BA and glucose metabolism regulators then draws interest from practical point of view. Conclusion. Bile acids carry out multiple physiological functions. The link between BA metabolism, liver disease and intestinal microbiome is demonstrated by numerous investigations.

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The authors declare that there are no conflicts of interest present.