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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2016-26-2-19-23</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-30</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГЕПАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEPATOLOGY</subject></subj-group></article-categories><title-group><article-title>К вопросу о клиническом применении неинвазивной диагностики фиброза печени при хроническом гепатите В</article-title><trans-title-group xml:lang="en"><trans-title>The issue of clinical application of non-invasive evaluation of liver fibrosis at chronic hepatitis B</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>Чавдар Савов</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>Chavdar S.</given-names></name></name-alternatives><email xlink:type="simple">chpavlov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Екатерина Алевтиновна</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>Ye. A.</given-names></name></name-alternatives><email xlink:type="simple">fraokat@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенистая</surname><given-names>Марианна Чавдаровна</given-names></name><name name-style="western" xml:lang="en"><surname>Semenistaya</surname><given-names>M. Ch.</given-names></name></name-alternatives><email xlink:type="simple">marianna.pavlova@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маевская</surname><given-names>Марина Викторовна</given-names></name><name name-style="western" xml:lang="en"><surname>Mayevskaya</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">mvmaevskaya@me.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>Владимир Трофимович</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><email xlink:type="simple">vladimirivashkin@rsls.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ЦИОП «Медицина будущего»; ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>«Meditsina buduschego»; State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>12</day><month>08</month><year>2016</year></pub-date><volume>26</volume><issue>2</issue><fpage>19</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Павлов Ч.С., Кузнецова Е.А., Семенистая М.Ч., Маевская М.В., Ивашкин В.Т., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Павлов Ч.С., Кузнецова Е.А., Семенистая М.Ч., Маевская М.В., Ивашкин В.Т.</copyright-holder><copyright-holder xml:lang="en">Pavlov C.S., Kuznetsova Y.A., Semenistaya M.C., Mayevskaya M.V., Ivashkin V.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/30">https://www.gastro-j.ru/jour/article/view/30</self-uri><kwd-group xml:lang="ru"><kwd>хронический гепатит В</kwd><kwd>неинвазивная диагностика</kwd><kwd>биопсия</kwd><kwd>показания к лечению</kwd><kwd>фиброз печени</kwd><kwd>цирроз</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Павлов Ч.С., Золотаревский В.Б., Шульпекова Ю.О. и др. Современные методы ранней диагностики фиброза печени. Клин мед 2005; 83(12):58-60.</mixed-citation><mixed-citation xml:lang="en">Павлов Ч.С., Золотаревский В.Б., Шульпекова Ю.О. и др. Современные методы ранней диагностики фиброза печени. Клин мед 2005; 83(12):58-60.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Павлов Ч.С., Глушенков Д.В., Ивашкин В.Т. Современные возможности эластометрии, фибро- и акти- теста в диагностике фиброза печени. Рос журн гастроэнтерол гепатол колопроктол 2008; 18(4):43-52.</mixed-citation><mixed-citation xml:lang="en">Павлов Ч.С., Глушенков Д.В., Ивашкин В.Т. Современные возможности эластометрии, фибро- и акти- теста в диагностике фиброза печени. Рос журн гастроэнтерол гепатол колопроктол 2008; 18(4):43-52.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Павлов Ч.С. Ивашкин В.Т. Как оценить и уменьшить риск фиброза, цирроза и гепатоцеллюлярной карциномы (ГЦК) у пациентов с хронической инфекцией вирусами гепатита В (HBV) и С (HCV). Росс журн гастроэнтерол гепатол колопроктол 2007; 17(5):16-23.</mixed-citation><mixed-citation xml:lang="en">Павлов Ч.С. Ивашкин В.Т. Как оценить и уменьшить риск фиброза, цирроза и гепатоцеллюлярной карциномы (ГЦК) у пациентов с хронической инфекцией вирусами гепатита В (HBV) и С (HCV). Росс журн гастроэнтерол гепатол колопроктол 2007; 17(5):16-23.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Павлов Ч.С., Золотаревский В.Б., Ивашкин В.Т. и др. Возможность обратимости цирроза печени (клинические и патогенетические предпосылки). Росс журн гастроэнтерол гепатол колопроктол 2006; 16(1):20-9.</mixed-citation><mixed-citation xml:lang="en">Павлов Ч.С., Золотаревский В.Б., Ивашкин В.Т. и др. Возможность обратимости цирроза печени (клинические и патогенетические предпосылки). Росс журн гастроэнтерол гепатол колопроктол 2006; 16(1):20-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Павлов Ч.С., Бакулин И.Г. Вирус гепатита В - основной этиологический фактор хронического вирусного гепатита, цирроза печени и гепатоцеллюлярной карциномы. Рус мед журн 2008; 4:157-60.</mixed-citation><mixed-citation xml:lang="en">Павлов Ч.С., Бакулин И.Г. Вирус гепатита В - основной этиологический фактор хронического вирусного гепатита, цирроза печени и гепатоцеллюлярной карциномы. Рус мед журн 2008; 4:157-60.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wong G.L., Chan H.L., Choi P.C., Chan A.W., Yu Z., Lai J.W., et al. Non-invasive algorithm of enhanced liver fibrosis and liver stiffness measurement with transient elastography for advanced liver fibrosis in chronic hepatitis B. Aliment Pharmacol Ther 2014; 39:197-208.</mixed-citation><mixed-citation xml:lang="en">Wong G.L., Chan H.L., Choi P.C., Chan A.W., Yu Z., Lai J.W., et al. Non-invasive algorithm of enhanced liver fibrosis and liver stiffness measurement with transient elastography for advanced liver fibrosis in chronic hepatitis B. Aliment Pharmacol Ther 2014; 39:197-208.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Papatheodoridis G.V., Manolakopoulos S., Liaw Y.F., Lok A. Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: a systematic review. J Hepatol 2012; 57:196-202.</mixed-citation><mixed-citation xml:lang="en">Papatheodoridis G.V., Manolakopoulos S., Liaw Y.F., Lok A. Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: a systematic review. J Hepatol 2012; 57:196-202.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">EASL Clinical Practice Guidelines: management of chronic hepatitis B virus infection. J Hepatol 2012; 57:167-85.</mixed-citation><mixed-citation xml:lang="en">EASL Clinical Practice Guidelines: management of chronic hepatitis B virus infection. J Hepatol 2012; 57:167-85.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Liaw Y.F., Kao J.H., Piratvisuth T, Chan H.L., Chien R.N., Liu C.J., et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int 2012; 6:531-61.</mixed-citation><mixed-citation xml:lang="en">Liaw Y.F., Kao J.H., Piratvisuth T, Chan H.L., Chien R.N., Liu C.J., et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int 2012; 6:531-61.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Marcellin P., Gane E., Buti M., Afdhal N., Sievert W., Jacobson I.M., et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet 2013; 381:468-475.</mixed-citation><mixed-citation xml:lang="en">Marcellin P., Gane E., Buti M., Afdhal N., Sievert W., Jacobson I.M., et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet 2013; 381:468-475.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kuo Y.H., Lu S.N., Chen C.H., Chang K.C., Hung C.H., Tai W.C., et al. The changes of liver stiffness and its associated factors for chronic hepatitis B patients with entecavir therapy. PLoS One 2014; 9:e93160.</mixed-citation><mixed-citation xml:lang="en">Kuo Y.H., Lu S.N., Chen C.H., Chang K.C., Hung C.H., Tai W.C., et al. The changes of liver stiffness and its associated factors for chronic hepatitis B patients with entecavir therapy. PLoS One 2014; 9:e93160.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Poynard T., Vergniol J., Ngo Y., Foucher J., Thibault V., Munteanu M., et al. Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest(R)) and elastography (FibroScan(R)). J Hepatol 2014; 61:994-1003.</mixed-citation><mixed-citation xml:lang="en">Poynard T., Vergniol J., Ngo Y., Foucher J., Thibault V., Munteanu M., et al. Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest(R)) and elastography (FibroScan(R)). J Hepatol 2014; 61:994-1003.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">de Ledinghen V., Vergniol J., Barthe C., Foucher J., ChermakF., Le Bail B., et al. Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus. Aliment Pharmacol Ther 2013; 37:979-88.</mixed-citation><mixed-citation xml:lang="en">de Ledinghen V., Vergniol J., Barthe C., Foucher J., ChermakF., Le Bail B., et al. Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus. Aliment Pharmacol Ther 2013; 37:979-88.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kim M.N., Kim S.U., Kim B.K., Park J.Y., Kim D.Y., Ahn S.H., et al. Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with transient elastography- defined subclinical cirrhosis. Hepatology 2015. http:// dx.doi.org/10.1002/hep.27735.</mixed-citation><mixed-citation xml:lang="en">Kim M.N., Kim S.U., Kim B.K., Park J.Y., Kim D.Y., Ahn S.H., et al. Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with transient elastography- defined subclinical cirrhosis. Hepatology 2015. http:// dx.doi.org/10.1002/hep.27735.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Journal of Hepatology 2015; 63:237-64</mixed-citation><mixed-citation xml:lang="en">EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Journal of Hepatology 2015; 63:237-64</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
