<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2019-29-4-22-29</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-394</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Гастроэзофагеальная рефлюксная болезнь и эрозивно-язвенные поражения гастродуоденальной зоны у школьников Сибири различного возраста</article-title><trans-title-group xml:lang="en"><trans-title>Gastroesophageal Reflux Disease and Erosive-Ulcerative Lesions of the Gastroduodenal Zone in Schoolchildren of Various Ages in Siberia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каспаров</surname><given-names>Э. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasparov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, директор 660022, г. Красноярск, ул. Партизана Железняка, д. 3г</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Director 660022, Krasnoyarsk, Partizana Zheleznyaka str., 3g</p></bio><email xlink:type="simple">impn@impn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поливанова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polivanova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, главный научный сотрудник клинического отделения патологии пищеварительной системы у взрослых и детей660022, г. Красноярск, ул. Партизана Железняка, д. 3г</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Principal Researcher, Clinical Department of Digestive System Pathology in Adults and Children660022, Krasnoyarsk, Partizana Zheleznyaka str., 3</p></bio><email xlink:type="simple">tamara-polivanova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вшивков</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vshivkov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, старший научный сотрудник клинического отделения патологии пищеварительной системы у взрослых и детей660022, г. Красноярск, ул. Партизана Железняка, д. 3г</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Senoir Researcher, Clinical Department of Digestive System Pathology in Adults and Children660022, Krasnoyarsk, Partizana Zheleznyaka str., 3g.</p></bio><email xlink:type="simple">vitali1983@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр “Красноярский научный центр Сибирского отделения Российской академии наук”» — Научно-исследовательский институт медицинских проблем Севера</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences” – Scientific Research Institute of Medical Problems of the North</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>22</day><month>09</month><year>2019</year></pub-date><volume>29</volume><issue>4</issue><fpage>22</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каспаров Э.В., Поливанова Т.В., Вшивков В.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Каспаров Э.В., Поливанова Т.В., Вшивков В.А.</copyright-holder><copyright-holder xml:lang="en">Kasparov E.V., Polivanova T.V., Vshivkov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/394">https://www.gastro-j.ru/jour/article/view/394</self-uri><abstract><p>Цель исследования: изучить распространенность гастроэзофагеальной рефлюксной болезни (ГЭРБ) и эрозивно-язвенных поражений гастродуоденальной зоны и их ассоциацию в возрастных группах школьников Сибири.Материал и методы. Проведено поперечное обследование школьников в населенных пунктах Республики Тыва, Эвенкии и Бурятии в возрасте 7–17 лет методом анкетирования для выявления у них гастроинтестинальных жалоб. Обследовано 1535 школьников (7–11 лет — 855 и 12–17 лет — 680 чел.) в Тыве, 790 (7–11 лет — 333 и 12–17 лет — 457 чел.) в Бурятии и 1369 (7–11 лет — 633 и 12–17 лет — 736 чел.) в Эвенкии. Диагностика ГЭРБ у школьников базировалась на наличии жалоб на изжогу на основании всемирного консенсуса определения ГЭРБ в педиатрической популяции. Методом случайного отбора в возрастных группах школьников с гастроинтестинальными жалобами каждого региона проведена эзофагогастродуоденоскопия (283 детям в Тыве, 110 в Бурятии и 205 — в Эвенкии).Результаты. Распространенность ГЭРБ среди школьников Сибири составила 6,4 %. При этом клинические признаки ГЭРБ преимущественно отмечали школьники старшей возрастной группы: в возрасте 12–17 лет в 9,4 % случаев, в возрасте 7–11 лет в 3,2 % (p = 0,01). Показатели в Республике Тыва были 9,5 %, что выше, чем у школьников Бурятии (4,1 %; p = 0,01) и Эвенкии (4,2 %; p = 0,01). Заболевание было представлено преимущественно неэрозивной формой. У младших школьников неэрозивная форма ГЭРБ диагностирована значительно реже и только в Тыве (14,0 %). Эрозивный эзофагит диагностирован в 4 случаях (0,7 %), 3 из которых у школьников старшего возраста в Тыве. Эрозивно-язвенные заболевания желудка и ДПК регистрировались в большей степени у старших детей и также наиболее часто в Тыве. Более частое сочетание ГЭРБ и эрозивно-язвенного поражения гастродуоденальной зоны отмечено в Тыве, особенно в старшей возрастной группе.Заключение. У школьников Сибири установлена ассоциация эрозивно-язвенного поражения слизистой гастродуоденальной зоны с ГЭРБ, выраженность которой имеет возрастные особенности и тесным образом связана с регионом проживания.</p></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the prevalence of gastroesophageal reflux disease (GERD) and erosive-ulcerative lesions of the gastroduodenal zone and their association among various age groups of Siberian schoolchildren.</p></sec><sec><title>Material and methods</title><p>Material and methods. In order to identify gastrointestinal complaints, a cross-sectional survey of schoolchildren at the age of 7–17 years in the settlements of the Republic of Tyva, Evenkia and Buryatia was conducted. In total, 1535 schoolchildren were examined (7–11 years old — 855 and 12–17 years old — 680 people) in Tyva, 790 (7–11 years old — 333 and 12–17 years old — 457 people) in Buryatia and 1369 (7–11 years old — 633 and 12–17 years old — 736 people) in Evenkia. GERD diagnosis in schoolchildren was based on the presence of heartburn complaints following the worldwide consensus on the GERD definition among the pediatric population. An esophagogastroduodenoscopy (283 children in Tyva, 110 in Buryatia and 205 in Evenkia) was performed by random selection in the age groups of schoolchildren with gastrointestinal complaints in each region.</p></sec><sec><title>Results</title><p>Results. The GERD prevalence among schoolchildren in Siberia was 6.4 %. At the same time, the clinical signs of GERD were mainly noted in schoolchildren of the older age group: at the age of 12–17 years old in 9.4 % of cases, at the age of 7–11 years old in 3.2 % (p = 0.01) of cases. The indicators in the Republic of Tyva were 9.5 %, which is higher than those for schoolchildren in Buryatia (4.1 %; p = 0.01) and Evenkia (4.2 %; p = 0.01). The disease was represented mainly by a non-erosive form. In younger schoolchildren, the non-erosive form of GERD is diagnosed much less frequently and only in Tyva (14.0 %). Erosive esophagitis was diagnosed in 4 cases (0.7 %), 3 of which were in older schoolchildren in Tyva. Erosive-ulcerative diseases of the stomach and duodenum were recorded, to a greater extent, in older children, and largely in Tyva. A more frequent combination of GERD and erosive-ulcerative lesions of the gastroduodenal zone was noted in Tyva, particularly in the older age group.</p></sec><sec><title>Conclusion</title><p>Conclusion. In Siberian schoolchildren, an association of erosive and ulcerative lesions of the mucosa of the gastroduodenal zone with GERD was established, the severity of which has age-related features and is closely related to the region of residence.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>популяция</kwd><kwd>распространенность</kwd><kwd>гастрит с эрозиями</kwd><kwd>язвенная болезнь</kwd><kwd>ГЭРБ</kwd><kwd>эрозивный эзофагит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>population</kwd><kwd>prevalence</kwd><kwd>erosive gastritis</kwd><kwd>peptic ulcer</kwd><kwd>GERD</kwd><kwd>erosive esophagitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Запруднов А.М., Григорьев К.И., Харитонова Л.А., Богомаз Л.В., Юдина Т.М. Проблемы и перспективы современной детской гастроэнтерологии. Педиатрия. Журнал им. Г.Н. Сперанского. 2016;6:10–8</mixed-citation><mixed-citation xml:lang="en">Zaprudnov A.M., Grigoriev K.I., Haritonova L.A., Bogomaz L.V., Yudina T.M. Problems and perspectives of modern pediatric gastroenterology. Pediatrics. Journal them. G.N. Speransky. 2016;6:10–8 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Турдыева Ш.Т. Выявление групп риска хронической гастродуоденальной патологии среди детей и подростков. Вопросы детской диетологии. 2015;13(6):18–22</mixed-citation><mixed-citation xml:lang="en">Turdyeva Sh.T. Detection of risk groups of chronic gastroduodenal pathology among children and adolescents. Questions of Children’s Dietology. 2015;13(6):18–22 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Клименко А.А. Гастродуоденальная патология у детей дошкольного и школьного возраста. Medicus. 2015;5(5):52–4</mixed-citation><mixed-citation xml:lang="en">Klimenko A.A. Gastro-duodenal abnormity at preschool and schoolchildren Medicus. 2015;5(5):52–4 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Reveiz L., Guerrero-Lozano R., Camacho A., Yara L., Mosquera P.A. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr. Crit. Care Med. 2010;11(1):124–32. DOI: 10.1097 / PCC.0b013e3181b80e70</mixed-citation><mixed-citation xml:lang="en">Klimenko A.A. Gastro-duodenal abnormity at preschool and schoolchildren Medicus. 2015;5(5):52–4 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tang Z., Shi J., Ji M., Shi P., Huang Z., Huang Y. The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up. Saudi J Gastroenterol. 2018;24(6):360–4. DOI: 10.4103/sjg.SJG_147_18</mixed-citation><mixed-citation xml:lang="en">Klimenko A.A. Gastro-duodenal abnormity at preschool and schoolchildren Medicus. 2015;5(5):52–4 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mousa H., Hassan M. Gastroesophageal Reflux Disease. Pediatr. Clin. North Am. 2017;64(3):487–505. DOI: 10.1016 / j.pcl.2017.01.003</mixed-citation><mixed-citation xml:lang="en">Reveiz L., Guerrero-Lozano R., Camacho A., Yara L., Mosquera P.A. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr. Crit. Care Med. 2010;11(1):124–32. DOI: 10.1097 / PCC.0b013e3181b80e70</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ristic N., Milovanovic I., Radusinovic M., Stevic M., et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One. 2017;12(11):e0187081. DOI: 10.1371/ journal.pone.0187081</mixed-citation><mixed-citation xml:lang="en">Reveiz L., Guerrero-Lozano R., Camacho A., Yara L., Mosquera P.A. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr. Crit. Care Med. 2010;11(1):124–32. DOI: 10.1097 / PCC.0b013e3181b80e70</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Шептулин А.А., Маев И.В., Баранская Е.К., Трухманов А.С., Лапина Т.Л., Бурков С.Г., Калинин А.В., Ткачев А.В. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению язвенной болезни. Рос журн гастроэнтерол гепатол колопроктол 2016;26(6):40–54</mixed-citation><mixed-citation xml:lang="en">Reveiz L., Guerrero-Lozano R., Camacho A., Yara L., Mosquera P.A. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr. Crit. Care Med. 2010;11(1):124–32. DOI: 10.1097 / PCC.0b013e3181b80e70</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation><mixed-citation xml:lang="en">Reveiz L., Guerrero-Lozano R., Camacho A., Yara L., Mosquera P.A. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr. Crit. Care Med. 2010;11(1):124–32. DOI: 10.1097 / PCC.0b013e3181b80e70</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Маев И.В., Трухманов А.С., Баранская Е.К., Дронова О.Б., Зайратьянц О.В., Сайфутдинов Р.Г., Шептулин А.А., Лапина Т.Л., Пирогов С.С., Кучерявый Ю.А., Сторонова О.А., Андреев Д.Н. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению гастроэзофагеальной рефлюксной болезни. Рос журн гастроэнтерол гепатол колопроктол 2017;27(4):75–95. DOI: 10.22416/1382437620172747595</mixed-citation><mixed-citation xml:lang="en">Tang Z., Shi J., Ji M., Shi P., Huang Z., Huang Y. The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up. Saudi J Gastroenterol. 2018;24(6):360–4. DOI: 10.4103/sjg.SJG_147_18</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation><mixed-citation xml:lang="en">Tang Z., Shi J., Ji M., Shi P., Huang Z., Huang Y. The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up. Saudi J Gastroenterol. 2018;24(6):360–4. DOI: 10.4103/sjg.SJG_147_18</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation><mixed-citation xml:lang="en">Tang Z., Shi J., Ji M., Shi P., Huang Z., Huang Y. The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up. Saudi J Gastroenterol. 2018;24(6):360–4. DOI: 10.4103/sjg.SJG_147_18</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation><mixed-citation xml:lang="en">Tang Z., Shi J., Ji M., Shi P., Huang Z., Huang Y. The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up. Saudi J Gastroenterol. 2018;24(6):360–4. DOI: 10.4103/sjg.SJG_147_18</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation><mixed-citation xml:lang="en">Mousa H., Hassan M. Gastroesophageal Reflux Disease. Pediatr. Clin. North Am. 2017;64(3):487–505. DOI: 10.1016 / j.pcl.2017.01.003</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Броева М.И., Сурков А.Н., Черников В.В. Современные проблемы диагностики и лечения функциональных заболеваний желудочно-кишечного тракта у детей. Педиатрическая фармакология. 2017;14(6):527–34</mixed-citation><mixed-citation xml:lang="en">Mousa H., Hassan M. Gastroesophageal Reflux Disease. Pediatr. Clin. North Am. 2017;64(3):487–505. DOI: 10.1016 / j.pcl.2017.01.003</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation><mixed-citation xml:lang="en">Mousa H., Hassan M. Gastroesophageal Reflux Disease. Pediatr. Clin. North Am. 2017;64(3):487–505. DOI: 10.1016 / j.pcl.2017.01.003</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation><mixed-citation xml:lang="en">Mousa H., Hassan M. Gastroesophageal Reflux Disease. Pediatr. Clin. North Am. 2017;64(3):487–505. DOI: 10.1016 / j.pcl.2017.01.003</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Реброва О.Ю. Описание статистического анализа данных в оригинальных статьях. Типичные ошибки. Медицинские технологии. Оценка и выбор. 2011;4:36–40</mixed-citation><mixed-citation xml:lang="en">Ristic N., Milovanovic I., Radusinovic M., Stevic M., et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One. 2017;12(11):e0187081. DOI: 10.1371/ journal.pone.0187081</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation><mixed-citation xml:lang="en">Ristic N., Milovanovic I., Radusinovic M., Stevic M., et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One. 2017;12(11):e0187081. DOI: 10.1371/ journal.pone.0187081</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation><mixed-citation xml:lang="en">Ristic N., Milovanovic I., Radusinovic M., Stevic M., et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One. 2017;12(11):e0187081. DOI: 10.1371/ journal.pone.0187081</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ristic N., Milovanovic I., Radusinovic M., Stevic M., et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One. 2017;12(11):e0187081. DOI: 10.1371/ journal.pone.0187081</mixed-citation><mixed-citation xml:lang="en">Ristic N., Milovanovic I., Radusinovic M., Stevic M., et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One. 2017;12(11):e0187081. DOI: 10.1371/ journal.pone.0187081</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Sheptulin A.A., Mayev I.V., Baranskaya Ye.K., Trukhmanov A.S., Lapina T.L., Burkov S.G., Kalinin A.V., Tkachev A.V. Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2016;26(6):40–54 (In Russ.) DOI: 10.22416/1382-4376-2016-6-32-39</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Mayev I.V., Trukhmanov A.S., Baranskaya Ye.K., Dronova О.B., Zayratyants О.V., Sayfutdinov R.G., Sheptulin A.A., Lapina T.L., Pirogov S.S., Kucheryavy Yu.A., Storonova O.A., Andreyev D.N. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological Association. Ross z gastroenterol gepatol koloproktol 2017;27(4):75–95 (In Russ.) DOI: 10.22416/1382437620172747595</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation><mixed-citation xml:lang="en">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation><mixed-citation xml:lang="en">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation><mixed-citation xml:lang="en">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation><mixed-citation xml:lang="en">Jonaitis L., Kiudelis G., Kupcinskas L. Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study. Medicina (Kaunas). 2008;44(3):211–5.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation><mixed-citation xml:lang="en">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation><mixed-citation xml:lang="en">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation><mixed-citation xml:lang="en">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation><mixed-citation xml:lang="en">Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014;20(18):5191–204. DOI: 10.3748/wjg.v20.i18.5191</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation><mixed-citation xml:lang="en">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation><mixed-citation xml:lang="en">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation><mixed-citation xml:lang="en">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation><mixed-citation xml:lang="en">Shimozato A., Sasaki M., Ogasawara N. Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms. J. Gastrointestin. Liver Dis. 2017;26(4):363–8. DOI: 10.15403 / jgld.2014.1121.264.kas</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation><mixed-citation xml:lang="en">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation><mixed-citation xml:lang="en">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation><mixed-citation xml:lang="en">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation><mixed-citation xml:lang="en">Tack J., Pandolfino J.E. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):277–88. DOI: 10.1053/j.gastro.2017.09.047</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Broeva M.I., Surkov A.N., Chernikov V.V. Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children. Pediatric Pharmacology. 2017;14(6):527–34 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation><mixed-citation xml:lang="en">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation><mixed-citation xml:lang="en">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation><mixed-citation xml:lang="en">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation><mixed-citation xml:lang="en">Bontems P., Aksoy E., Burette A., Segers V., et al. NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults. Helicobacter. 2014;19(3):157–67. DOI: 10.1111/hel.12118</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation><mixed-citation xml:lang="en">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation><mixed-citation xml:lang="en">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation><mixed-citation xml:lang="en">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation><mixed-citation xml:lang="en">Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol. 2009;104(5):1278–95. DOI: 10.1038/ajg.2009.129</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Rebrova O.Yu. Description of Statistical Analysis of Data in Original Articles. Typical Errors. Medical technology. Evaluation and selection. 2011;4:36–40 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation><mixed-citation xml:lang="en">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation><mixed-citation xml:lang="en">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation><mixed-citation xml:lang="en">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation><mixed-citation xml:lang="en">Bor S., Kitapcioglu G., Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol. 2017;23(3):525–32. DOI: 10.3748/wjg.v23.i3.525</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation><mixed-citation xml:lang="en">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation><mixed-citation xml:lang="en">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation><mixed-citation xml:lang="en">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation><mixed-citation xml:lang="en">Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267–76. DOI: 10.1053/j.gastro.2017.07.045</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
