<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2019-29-6-15-21</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-448</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Возможности применения низкотемпературной аргоновой плазмы в лечении послеоперационных и длительно незаживающих ран</article-title><trans-title-group xml:lang="en"><trans-title>Possibilities for the Application of Low-Temperature Argon Plasma in the Treatment of Postoperative and Long-Term Non-Healing Wounds</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4697-2839</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Deputy Director, Research Consultation Clinic</p><p>123423, Moscow, Salyama Adilya str., 2 </p></bio><email xlink:type="simple">info@gnck.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7544-4752</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьминов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzminov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Departmental Head, Department of General Coloproctology combined with a group for studying the Familial Adenomatous Polyposis</p><p>123423, Moscow, Salyama Adilya str., 2 </p></bio><email xlink:type="simple">9249591@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вышегородцев</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vyshegorodtsev</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">info@gnck.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королик</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Korolik</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, научный сотрудник отдела общей проктологии с группой изучения семейного аденоматоза </p><p>123423, г. Москва, ул. Саляма Адиля, д. 2 </p></bio><bio xml:lang="en"/><email xlink:type="simple">v.korolik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Туктагулов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tuktagulov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический аспирант кафедры колопроктологии </p><p>123423, г. Москва, ул. Саляма Адиля, д. 2 </p></bio><bio xml:lang="en"/><email xlink:type="simple">Dr.tuktagulov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4795-0751</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухина</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhina</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук, руководитель отдела изучения микробиологических и иммунологических исследований </p><p>123423, г. Москва, ул. Саляма Адиля, д. 2.</p></bio><bio xml:lang="en"/><email xlink:type="simple">marinamari272015@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9219-6976</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">docmukhin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Государственный научный центр колопроктологии им. А.Н. Рыжих» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Center of Coloproctology named after A.N. Ryzhykh</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>31</day><month>01</month><year>2020</year></pub-date><volume>29</volume><issue>6</issue><fpage>15</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фролов С.А., Кузьминов А.М., Вышегородцев Д.В., Королик В.Ю., Туктагулов Н.В., Сухина М.А., Мухин И.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Фролов С.А., Кузьминов А.М., Вышегородцев Д.В., Королик В.Ю., Туктагулов Н.В., Сухина М.А., Мухин И.А.</copyright-holder><copyright-holder xml:lang="en">Frolov S.A., Kuzminov A.M., Vyshegorodtsev D.V., Korolik V.Y., Tuktagulov N.V., Sukhina M.A., Mukhin I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/448">https://www.gastro-j.ru/jour/article/view/448</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>заживление раны</kwd><kwd>низкотемпературная аргоновая плазма</kwd><kwd>хронические раны</kwd><kwd>длительно незаживающие раны</kwd><kwd>аргон</kwd><kwd>плазменный поток</kwd></kwd-group><kwd-group xml:lang="en"><kwd>wound healing</kwd><kwd>low-temperature argon plasma</kwd><kwd>chronic wounds</kwd><kwd>long-term non-healing wounds</kwd><kwd>argon</kwd><kwd>plasma flow</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Завражнов А.А., Гвоздев М. Ю., Крутова В.А., Ордокова А. А. Раны и раневой процесс. Учебно-методическое пособие для интернов, ординаторов и практических врачей. 2016:29.</mixed-citation><mixed-citation xml:lang="en">Zavrazhnov A.A., Gvozdev M.Yu., Krutova V.A., Ordokova A.A. Wound healing process. Teaching guidebook for interns, ordinators and practitioners. 2016:29 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кузин М.И. Рекомендации XXX съезда хирургов по проблеме «Гнойная инфекция в хирургии». Хирургия. 1981;12:38–9.</mixed-citation><mixed-citation xml:lang="en">Kuzin M.I. Recommendations of the XXX Congress of Surgeons on the problem of “Purulent infection in surgery”. Surgery. 1981;12:38–9 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кузин М.И. Раны и раневая инфекция: Руководство для врачей. М.: Медицина,1990:592.</mixed-citation><mixed-citation xml:lang="en">Kuzin M.I. Wounds and Wound Infection: A Guide for Physicians. Moscow: Meditsina; 1990:592 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Leaper D.J., van Goor H., Reilly J., Petrosillo N., Geiss H.K., Torres A.J., Berger A. Surgical site infection — a European perspective of incidence and economic burden. Int Wound J. 2004;1(4):247–73.</mixed-citation><mixed-citation xml:lang="en">Leaper D.J., van Goor H., Reilly J., Petrosillo N., Geiss H.K., Torres A.J., Berger A. Surgical site infection — a European perspective of incidence and economic burden. Int Wound J. 2004;1(4):247–73.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Гостищев В.К. Инфекции в хирургии. Руководство для врачей. М.: ГЭОТАР-Медиа; 2007:65–70.</mixed-citation><mixed-citation xml:lang="en">Gostishchev V.K. Infections in surgery. A guide for doctors. Moscow: GEOTAR-Media; 2007:65–70 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Петров С.В. Общая хирургия: учебник. 3-е изд. М.: ГЭОТАР-Медиа; 2010:768.</mixed-citation><mixed-citation xml:lang="en">Petrov S.V. General surgery: a textbook. 3rd ed. Moscow: GEOTAR-Media; 2010:768 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kirketerp-Møller K., Jensen P., Fazli M., G. Madsen K., Pedersen J., Moser C., Tolker-Nielsen T., Høiby N., Givskov M., Bjarnsholt T. Distribution, organization, and</mixed-citation><mixed-citation xml:lang="en">Kirketerp-Møller K., Jensen P., Fazli M., G. Madsen K., Pedersen J., Moser C., Tolker-Nielsen T., Høiby N., Givskov M., Bjarnsholt T. Distribution, organization, and ecology of bacteria in chronic wounds. J Clin Microbiol. 2008;46(8):2717–22. doi: 10.1128/JCM.00501-08.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">ecology of bacteria in chronic wounds. J Clin Microbiol. 2008;46(8):2717–22. doi: 10.1128/JCM.00501-08.</mixed-citation><mixed-citation xml:lang="en">Brekhov E.I., Kozlov N.P., Rebizov V.Yu. Experimental and clinical studies and prospects for the use of plasma flows. Surgery. 1989;(7):94–6 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Брехов Е.И., Козлов Н.П., Ребизов В.Ю. Экспериментальное и клиническое изучение и перспективы применения плазменных потоков. Хирургия. 1989;(7):94–6.</mixed-citation><mixed-citation xml:lang="en">Savelyev V.S., Stupin I.V., Volkoedov V.S., Beresnev V.S. Plasma scalpel. Surgery. 1987;(4):147–8 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Савельев В.С., Ступин И.В., Волкоедов В.С., Береснев В.С. Плазменный скальпель. Хирургия. 1987;(4):147–8.</mixed-citation><mixed-citation xml:lang="en">Friedman G., Gutsol A., Shekhter AV., Vasilets VN., Fridman A. Applied plasma medicine. Plasma Process Polymers. 2008;(5):503–33.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Friedman G., Gutsol A., Shekhter AV., Vasilets VN., Fridman A. Applied plasma medicine. Plasma Process Polymers. 2008;(5):503–33.</mixed-citation><mixed-citation xml:lang="en">Pleshkov V.G., Afanas’ev V.N., Babichev A.V. Use of plasma scalpel and one-layer suture in resection of the stomach. Khirurgiia. 1998;(11):27–9 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Плешков В.Г., Афанасьев В.Н., Бабичев А.В. Использование плазменного скальпеля и однорядного шва при резекции желудка. Хирургия.1998;11:27–29.</mixed-citation><mixed-citation xml:lang="en">Guild G.N. Runner R.P., Castilleja G.M., Smith M.J., Vu C.L. Efficacy of Hybrid Plasma Scalpel in Reducing Blood Loss and Transfusions in Direct Anterior Total Hip Arthroplasty. J Arthroplasty. 2017;32(2):458–462. doi: 10.1016/j.arth.2016.07.038.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Guild G.N. Runner R.P., Castilleja G.M., Smith M.J., Vu C.L. Efficacy of Hybrid Plasma Scalpel in Reducing Blood Loss and Transfusions in Direct Anterior Total Hip Arthroplasty. J Arthroplasty. 2017;32(2):458–462. doi: 10.1016/j.arth.2016.07.038.</mixed-citation><mixed-citation xml:lang="en">Somani S.K., Ghosh A., Avasthi G., Goyal R., Gupta P. Healing of solitary rectal ulcers with multiple sessions of argon plasma coagulation. Dig Endosc. 2010;22(2):107–11. doi: 10.1111/j.1443-1661.2010.00941.x.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Somani S.K., Ghosh A., Avasthi G., Goyal R., Gupta P. Healing of solitary rectal ulcers with multiple sessions of argon plasma coagulation. Dig Endosc. 2010;22(2):107–11. doi: 10.1111/j.1443-1661.2010.00941.x.</mixed-citation><mixed-citation xml:lang="en">Yu Y., Tan M., Chen H., Wu Z., Xu L., Li J., Cao J., Yang Y., Xiao X., Lian X., Lu X., Tu Y. Non-thermal plasma suppresses bacterial colonization on skin wound and promotes wound healing in mice. J Huazhong Univ Sci Technolog Med Sci. 2011;31(3):390–394. doi: 10.1007/s11596-011-0387-2.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yu Y., Tan M., Chen H., Wu Z., Xu L., Li J., Cao J., Yang Y., Xiao X., Lian X., Lu X., Tu Y. Non-thermal plasma suppresses bacterial colonization on skin wound and promotes wound healing in mice. J Huazhong Univ Sci Technolog Med Sci. 2011;31(3):390–394. doi: 10.1007/s11596-011-0387-2.</mixed-citation><mixed-citation xml:lang="en">Arndt S., Unger P., Wacker E., Shimizu T., Heinlin J., Li Y., Thomas H.M., Morfill G.E., Zimmermann J.L., Bosserhoff A., Karrer S. Cold Atmospheric Plasma (CAP) Changes Gene Expression of Key Molecules of the Wound Healing Machinery and Improves Wound Healing In Vitro and In Vivo. PLoS One. 2013;8(11):e79325. doi: 10.1371/journal.pone.0079325.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Arndt S., Unger P., Wacker E., Shimizu T., Heinlin J., Li Y., Thomas H.M., Morfill G.E., Zimmermann J.L., Bosserhoff A., Karrer S. Cold Atmospheric Plasma (CAP) Changes Gene Expression of Key Molecules of the Wound Healing Machinery and Improves Wound Healing In Vitro and In Vivo. PLoS One. 2013;8(11):e79325. doi: 10.1371/journal.pone.0079325.</mixed-citation><mixed-citation xml:lang="en">Gurtner G.C., Werner S., Barrandon Y., Longaker M.T. Wound repair and regeneration. Nature. 2008;453(7193):314–21.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Gurtner G.C., Werner S., Barrandon Y., Longaker M.T. Wound repair and regeneration. Nature. 2008;453(7193):314–21.</mixed-citation><mixed-citation xml:lang="en">Reinke J.M., Sorg H. Wound repair and regeneration. European surgical research. Europaische chirurgische Forschung. Eur Surg Res. 2012;49(1):35–43. doi: 10.1159/000339613.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Reinke J.M., Sorg H. Wound repair and regeneration. European surgical research. Europaische chirurgische Forschung. Eur Surg Res. 2012;49(1):35–43. doi: 10.1159/000339613.</mixed-citation><mixed-citation xml:lang="en">Haertel B., Wende K., von Woedtke T., Weltmann K.D., Lindequist U. Non-thermal atmospheric-pressure plasma can influence cell adhesion molecules on  HaCaTkeratinocytes. Exp Dermatol. 2011;20(3):282–4. doi: 10.1111/j.1600-0625.2010.01159.x.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Haertel B., Wende K., von Woedtke T., Weltmann K.D., Lindequist U. Non-thermal atmospheric-pressure plasma can influence cell adhesion molecules on HaCaTkeratinocytes. Exp Dermatol. 2011;20(3):282–4. doi: 10.1111/j.1600-0625.2010.01159.x.</mixed-citation><mixed-citation xml:lang="en">Watt F.M. Role of integrins in regulating epidermal adhesion, growth and  differentiation. EMBO J. 2002;21(15):3919–26.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Watt F.M. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 2002;21(15):3919–26.</mixed-citation><mixed-citation xml:lang="en">Heinlin J., Morfill G., Landthaler M., Stolz W., IsbaryG., Zimmermann J.L. Plasma medicine: possible applications in dermatology. J Dtsch Dermatol Ges. 2010;8(12):968–76. doi: 10.1111/j.1610-0387.2010.07495.x.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Heinlin J., Morfill G., Landthaler M., Stolz W., IsbaryG., Zimmermann J.L. Plasma medicine: possible applications in dermatology. J Dtsch Dermatol Ges. 2010;8(12):968–76. doi: 10.1111/j.1610-0387.2010.07495.x.</mixed-citation><mixed-citation xml:lang="en">Maisch T., Bosserhoff A. K., Unger P., Heider, J., Shimizu T., Zimmermann J.L., Morfill G.E., Landthaler M., Karrer S. Investigation of toxicity and mutagenicity of cold atmospheric argon plasma. Environ Mol Mutagen. 2017 ;58(3):172–177. doi: 10.1002/em.22086.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Maisch T., Bosserhoff A. K., Unger P., Heider, J., Shimizu T., Zimmermann J.L., Morfill G.E., Landthaler M., Karrer S. Investigation of toxicity and mutagenicity of cold atmospheric argon plasma. Environ Mol Mutagen. 2017 ;58(3):172–177. doi: 10.1002/em.22086.</mixed-citation><mixed-citation xml:lang="en">Wende K., Bekeschus S., Schmidt A., Jatsch L., Hasse S., Weltmann K.D, Masur K., von Woedtke T. Risk assessment of a cold argon plasma jet in respect to its mutagenicity. Mutat Res Genet Toxicol Environ Mutagen. 2016;798–799:48–54. doi: 10.1016/j.mrgentox.2016.02.003.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Wende K., Bekeschus S., Schmidt A., Jatsch L., Hasse S., Weltmann K.D, Masur K., von Woedtke T. Risk assessment of a cold argon plasma jet in respect to its mutagenicity. Mutat Res Genet Toxicol Environ Mutagen. 2016;798–799:48–54. doi: 10.1016/j.mrgentox.2016.02.003.</mixed-citation><mixed-citation xml:lang="en">Brehmer F., Haenssle H. A., Daeschlein G., Ahmed R., Pfeiffer S., Görlitz A., Simon D., Schön M.P., Wandke D., Emmert S. Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm® VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). J Eur Acad Dermatol Venereol. 2015;29(1):148–55. doi: 10.1111/jdv.12490.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Brehmer F., Haenssle H. A., Daeschlein G., Ahmed R., Pfeiffer S., Görlitz A., Simon D., Schön M.P., Wandke D., Emmert S. Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm® VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). J Eur Acad Dermatol Venereol. 2015;29(1):148–55. doi: 10.1111/jdv.12490.</mixed-citation><mixed-citation xml:lang="en">Moisan M., Barbeau J., Moreau S., Pelletier J., Tabrizian M., Yahia L.H. Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms. Int J Pharm. 2001;226(1–2):1–21.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Moisan M., Barbeau J., Moreau S., Pelletier J., Tabrizian M., Yahia L.H. Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms. Int J Pharm. 2001;226(1–2):1–21.</mixed-citation><mixed-citation xml:lang="en">Vatansever F., de Melo W.C., Avci P., Vecchio D., Sadasivam M., Gupta A., Chandran R., Karimi M., Parizotto N.A., Yin R., Tegos G.P., Hamblin M.R. Antimicrobial strategies centered around reactive oxygen species-bactericidal antibiotics, photodynamic therapy, and beyond. FEMS Microbiol Rev. 2013;37(6):955–89. doi: 10.1111/1574-6976.12026.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Vatansever F., de Melo W.C., Avci P., Vecchio D., Sadasivam M., Gupta A., Chandran R., Karimi M., Parizotto N.A., Yin R., Tegos G.P., Hamblin M.R. Antimicrobial strategies centered around reactive oxygen species-bactericidal antibiotics, photodynamic therapy, and beyond. FEMS Microbiol Rev. 2013;37(6):955–89. doi: 10.1111/1574-6976.12026.</mixed-citation><mixed-citation xml:lang="en">Mai-Prochnow A., Murphy A.B., McLean K.M., Kong M.G., Ostrikov K. Atmospheric pressure plasmas: Infection control and bacterial responses. Int J Antimicrob Agents. 2014;43(6):508–17. doi: 10.1016/j.ijantimicag.2014.01.025.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mai-Prochnow A., Murphy A.B., McLean K.M., Kong M.G., Ostrikov K. Atmospheric pressure plasmas: Infection control and bacterial responses. Int J Antimicrob Agents. 2014;43(6):508–17. doi: 10.1016/j.ijantimicag.2014.01.025.</mixed-citation><mixed-citation xml:lang="en">Ermolaeva S.A., Sysoliatina E.V., Kolkova N.I., Drobiashchenko M.A., Vasil’ev M.M., Tukhvatulin A.I., Petrov O.F., Naroditskiĭ B.S., Morfill G.E., Fortov V.F., Grigor’ev A.I., Zigangirova N.A., Gintsburg A.L. New approaches to therapy of persistent infections: elimination of intracellular Chlamydai trachomatis by exposure to low temperature argon plasma. Zhurnal mikrobiologii, epidemiologii, i immunobiologii. 2012;(4):33–7 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ермолаева С.А., Сысолятина Е.В., Колкова Н.И., Дробященко М.А., Васильев М.М., Тухватулин А.И., Петров О.Ф., Народицкий Б.С., Морфил Дж.Е., Фортов В.Е., Григорьев А.И., Зигангирова Н.А., Гинцбург А.Л. Новые подходы к терапии</mixed-citation><mixed-citation xml:lang="en">Joshi S.G., Cooper M., Yost A., Paff M., Ercan U.K., Fridman G., Friedman G., Fridman A., Brooks A.D. Nonthermal dielectric-barrier discharge plasma-induced inactivation involves oxidative DNA damage and membrane lipid peroxidation in Escherichia coli. Antimicrob Agents Chemother. 2011;55(3):1053–62. doi: 10.1128/AAC.01002-10.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">перистирующих инфекций: элиминация внутриклеточных Chlamydia trachomatis путем воздействия низкотемпературной аргоновой плазмой. Журнал микробиологии, эпидемиологии и иммунологии. 2012;(4):33–7.</mixed-citation><mixed-citation xml:lang="en">Yusupov M. Plasma-Induced Destruction of Bacterial Cell Wall Components: A Reactive Molecular Dynamics Simulation. J. Phys. Chem. 2013:5993–8. doi:10.1021/jp3128516</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Joshi S.G., Cooper M., Yost A., Paff M., Ercan U.K., Fridman G., Friedman G., Fridman A., Brooks A.D. Nonthermal dielectric-barrier discharge plasma-induced inactivation involves oxidative DNA damage and membrane lipid peroxidation in Escherichia coli. Antimicrob Agents Chemother. 2011;55(3):1053–62. doi: 10.1128/AAC.01002-10.</mixed-citation><mixed-citation xml:lang="en">Yusupov M. Plasma-Induced Destruction of Bacterial Cell Wall Components: A Reactive Molecular Dynamics Simulation. J. Phys. Chem. 2013:5993–8. doi:10.1021/jp3128516</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Yusupov M. Plasma-Induced Destruction of Bacterial Cell Wall Components: A Reactive Molecular Dynamics Simulation. J. Phys. Chem. 2013:5993–8. doi:10.1021/jp3128516</mixed-citation><mixed-citation xml:lang="en">Mai-Prochnow A., Clauson M., Hong J., Murphy A.B. Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma. Scientific Reports. 2016;6(1):38610.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Mai-Prochnow A., Clauson M., Hong J., Murphy A.B. Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma. Scientific Reports. 2016;6(1):38610.</mixed-citation><mixed-citation xml:lang="en">Mai-Prochnow A., Clauson M., Hong J., Murphy A.B. Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma. Scientific Reports. 2016;6(1):38610.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Wiegand C., Beier O., Horn K., Pfuch. A., Tölke T., Hipler U.-C., Schimanski A. Antimicrobial Impact of Cold Atmospheric Pressure Plasma on Medical Critical Yeasts and Bacteria Cultures. Skin Pharmacol Physiol. 2014;27(1):25–35. doi: 10.1159/000351353.</mixed-citation><mixed-citation xml:lang="en">Wiegand C., Beier O., Horn K., Pfuch. A., Tölke T., Hipler U.-C., Schimanski A. Antimicrobial Impact of Cold Atmospheric Pressure Plasma on Medical Critical Yeasts and Bacteria Cultures. Skin Pharmacol Physiol. 2014;27(1):25–35. doi: 10.1159/000351353.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ermolaeva S.A., Rakovskaya I.V., Miller G.G., Sysolyatina E.V., Mukhachev A.Y., Vasiliev M.M., Adgamov R.R., Levina G.A., Petrov O.F., Morfill G.E., Grigoriev A.I., Fortov V.E., Gintsburg A.L. Nonthermal plasma affects viability and morphology of Mycoplasma hominis and Acholeplasma laidlawii. J Appl Microbiol. 2014;116(5):1129–36. doi: 10.1111/jam.12445.</mixed-citation><mixed-citation xml:lang="en">Wiegand C., Beier O., Horn K., Pfuch. A., Tölke T., Hipler U.-C., Schimanski A. Antimicrobial Impact of Cold Atmospheric Pressure Plasma on Medical Critical Yeasts and Bacteria Cultures. Skin Pharmacol Physiol. 2014;27(1):25–35. doi: 10.1159/000351353.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Милешкин Н.С. Биопленка как форма существования микроорганизмов. Действие факторов иммунной системы. Международный студенческий научный вестник. 2017;(2):32.</mixed-citation><mixed-citation xml:lang="en">Ermolaeva S.A., Rakovskaya I.V., Miller G.G., Sysolyatina E.V., Mukhachev A.Y., Vasiliev M.M., Adgamov R.R., Levina G.A., Petrov O.F., Morfill G.E., Grigoriev A.I., Fortov V.E., Gintsburg A.L. Nonthermal plasma affects viability and morphology of Mycoplasma hominis and Acholeplasma laidlawii. J Appl Microbiol. 2014;116(5):1129–36. doi: 10.1111/jam.12445.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Traba C., Liang Traba J.F. The inactivation of Staphylococcus aureus biofilms using low-power argon plasma in a layer-by-layer approach. Biofouling. 2015;31(1):39–48. doi: 10.1080/08927014.2014.995643.</mixed-citation><mixed-citation xml:lang="en">Ermolaeva S.A., Rakovskaya I.V., Miller G.G., Sysolyatina E.V., Mukhachev A.Y., Vasiliev M.M., Adgamov R.R., Levina G.A., Petrov O.F., Morfill G.E., Grigoriev A.I., Fortov V.E., Gintsburg A.L. Nonthermal plasma affects viability and morphology of Mycoplasma hominis and Acholeplasma laidlawii. J Appl Microbiol. 2014;116(5):1129–36. doi: 10.1111/jam.12445.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Chuangsuwanich A., Assadamongkol T., Boonyawan D. The Healing Effect of Low-Temperature Atmospheric-Pressure Plasma in Pressure Ulcer: A Randomized Controlled Trial. Int J Low Extrem Wounds. 2016;15(4):313–9. doi: 10.1177/1534734616665046</mixed-citation><mixed-citation xml:lang="en">Mileshkin N.S. Biofilm as a form of microorganism existence. The action of factors of the immune system. International Student Scientific Herald. 2017;(2):32 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Османов Э.Г.-о. Инновационные плазменно-хирургические технологии в комплексном лечении воспалительно-гнойных поражений мягких тканей: автореф. дис. …докт. мед. наук. 2009:290.</mixed-citation><mixed-citation xml:lang="en">Mileshkin N.S. Biofilm as a form of microorganism existence. The action of factors of the immune system. International Student Scientific Herald. 2017;(2):32 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Traba C., Liang Traba J.F. The inactivation of Staphylococcus aureus biofilms using low-power argon plasma in a layer-by-layer approach. Biofouling. 2015;31(1):39–48. doi: 10.1080/08927014.2014.995643.</mixed-citation><mixed-citation xml:lang="en">Traba C., Liang Traba J.F. The inactivation of Staphylococcus aureus biofilms using low-power argon plasma in a layer-by-layer approach. Biofouling. 2015;31(1):39–48. doi: 10.1080/08927014.2014.995643.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Traba C., Liang Traba J.F. The inactivation of Staphylococcus aureus biofilms using low-power argon plasma in a layer-by-layer approach. Biofouling. 2015;31(1):39–48. doi: 10.1080/08927014.2014.995643.</mixed-citation><mixed-citation xml:lang="en">Traba C., Liang Traba J.F. The inactivation of Staphylococcus aureus biofilms using low-power argon plasma in a layer-by-layer approach. Biofouling. 2015;31(1):39–48. doi: 10.1080/08927014.2014.995643.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Chuangsuwanich A., Assadamongkol T., Boonyawan D. The Healing Effect of Low-Temperature Atmospheric-Pressure Plasma in Pressure Ulcer: A Randomized Controlled Trial. Int J Low Extrem Wounds. 2016;15(4):313–9. doi: 10.1177/1534734616665046</mixed-citation><mixed-citation xml:lang="en">Chuangsuwanich A., Assadamongkol T., Boonyawan D. The Healing Effect of Low-Temperature Atmospheric-Pressure Plasma in Pressure Ulcer: A Randomized Controlled Trial. Int J Low Extrem Wounds. 2016;15(4):313–9. doi: 10.1177/1534734616665046</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Chuangsuwanich A., Assadamongkol T., Boonyawan D. The Healing Effect of Low-Temperature Atmospheric-Pressure Plasma in Pressure Ulcer: A Randomized Controlled Trial. Int J Low Extrem Wounds. 2016;15(4):313–9. doi: 10.1177/1534734616665046</mixed-citation><mixed-citation xml:lang="en">Chuangsuwanich A., Assadamongkol T., Boonyawan D. The Healing Effect of Low-Temperature Atmospheric-Pressure Plasma in Pressure Ulcer: A Randomized Controlled Trial. Int J Low Extrem Wounds. 2016;15(4):313–9. doi: 10.1177/1534734616665046</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Osmanov E.G.-o. Innovative plasma-surgical technologies in the complex treatment of inflammatory-purulent lesions of soft tissues: abstract. diss. … Dr. Sci. (Med.). 2009:290 (In Rus.)</mixed-citation><mixed-citation xml:lang="en">Osmanov E.G.-o. Innovative plasma-surgical technologies in the complex treatment of inflammatory-purulent lesions of soft tissues: abstract. diss. … Dr. Sci. (Med.). 2009:290 (In Rus.)</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Osmanov E.G.-o. Innovative plasma-surgical technologies in the complex treatment of inflammatory-purulent lesions of soft tissues: abstract. diss. … Dr. Sci. (Med.). 2009:290 (In Rus.)</mixed-citation><mixed-citation xml:lang="en">Osmanov E.G.-o. Innovative plasma-surgical technologies in the complex treatment of inflammatory-purulent lesions of soft tissues: abstract. diss. … Dr. Sci. (Med.). 2009:290 (In Rus.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
