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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2020-30-5-58-62</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-460</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Беременность и благополучный исход родов у пациентки 37 лет с дивертикулярной болезнью ободочной кишки</article-title><trans-title-group xml:lang="en"><trans-title>Pregnancy and Healthy Childbirth in a 37 Year-Old Patient with Diverticular Disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0264-7305</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreev</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андреев Павел Сергеевич - кандидат медицинских наук, врач-колопроктолог, доцент кафедры госпитальной хирургии</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p></bio><bio xml:lang="en"><p>Pavel S. Andreev - Cand. Sci. (Med.), Physician (coloproctology), Assoc. Prof., Chair of Hospital Surgery</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p></bio><email xlink:type="simple">pashaandreev@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7473-6692</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каторкин</surname><given-names>С. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Katorkin</surname><given-names>S. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каторкин Сергей Евгеньевич - доктор медицинских наук, врач-колопроктолог, заведующий кафедрой и клиникой госпитальной хирургии</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p></bio><bio xml:lang="en"><p>Sergey E. Katorkin - Dr. Sci. (Med.), Physician (coloproctology), Head of the Chair and Clinic of Hospital Surgery</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p></bio><email xlink:type="simple">katorkinse@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2403-1990</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдова</surname><given-names>О. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydova</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давыдова Ольга Евгеньевна — кандидат медицинских наук, врач-колопроктолог Клиники</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p></bio><bio xml:lang="en"><p>Olga E. Davydova - Cand. Sci. (Med.), Physician (coloproctology), Clinic of Hospital Surgery</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p></bio><email xlink:type="simple">davidolga77@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2020</year></pub-date><volume>30</volume><issue>5</issue><fpage>58</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Андреев П.С., Каторкин С.Е., Давыдова О.Е., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Андреев П.С., Каторкин С.Е., Давыдова О.Е.</copyright-holder><copyright-holder xml:lang="en">Andreev P.S., Katorkin S.E., Davydova O.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/460">https://www.gastro-j.ru/jour/article/view/460</self-uri><abstract><sec><title>Цель</title><p>Цель: представить клиническое наблюдение беременности и успешного родоразрешения у молодой пациентки с неосложненной формой дивертикулярной болезни (ДБ).</p></sec><sec><title>Основные положения</title><p>Основные положения. В последние годы отмечается тенденция к снижению возраста начала ДБ. У женщины 37 лет симптомы ДБ манифестировали периодическими интенсивными болями в животе и постоянным ощущением дискомфорта в животе. По результатам ирригоскопии диагностирована ДБ ободочной кишки. Назначены высокошлаковая диета, рифаксимин-α по 400 мг 2 раза в день в течение 1 недели 1 раз в месяц в течение полугода, местная противовоспалительная терапия. Благодаря проводимому лечению достигнута ликвидация клинической симптоматики. Не зная о наступившей беременности, пациентка на второй неделе беременности приняла очередной курс рифаксимина-α. Медикаментозная терапия ДБ была остановлена. Рифаксимин-α, который практически не всасывается в кишечнике, не повлиял на развитие плода. Родоразрешение прошло благополучно посредством кесарева сечения, ребенок родился в срок без осложнений (оценка по шкале Апгар - 8 баллов).</p></sec><sec><title>Заключение</title><p>Заключение. ДБ следует включать в круг дифференциального диагноза у пациентов с неспецифическими симптомами (боль, вздутие и дискомфорт в животе), несмотря на молодой возраст. В настоящее время отсутствуют протоколы по ведению дивертикулярной болезни во время беременности. В представленном клиническом наблюдении беременность у пациентки, страдающей дивертикулярной болезнью и принимавшей на ранних ее сроках рифаксимин-α, протекала без осложнений со стороны матери и плода.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To describe a clinical case of pregnancy and healthy labour in a young female patient with uncomplicated diverticular disease (DD).</p></sec><sec><title>Key points</title><p>Key points. In recent years, DD is more frequently observed in younger patients. A 37-yo woman manifested the symptoms of periodic intense abdominal pain and constant abdominal discomfort. Colonic DD was diagnosed with irrigoscopy. A high-fibre diet, rifaximin-α at 400 mg twice a day for one week, once a month for six months, and topical anti-inflammatory therapy were prescribed. Clinical symptoms were eradicated upon the treatment. Unaware of pregnancy, the patient had another course of rifaximin-α at the second week of gestation, after which the therapy was stopped. Rifaximin-α, which has a poor intestinal absorption, did not affect the foetal development. A caesarean childbirth was healthy, the newborn was delivered on term with no complications (Apgar score 8).</p></sec><sec><title>Conclusion</title><p>Conclusion. DD should be included in differential diagnosis for patients with non-specific symptoms (abdominal pain, bloating and discomfort), regardless of young age. No protocols are currently accepted for the DD management during gestation. In the clinical case reported, a patient having diverticular disease and a rifaximin-α therapy at an early term of gestation proceeded without complications for herself and the foetus.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дивертикулярная болезнь</kwd><kwd>рифаксимин-α</kwd><kwd>беременность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diverticular disease</kwd><kwd>rifaximin-α</kwd><kwd>pregnancy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация при поддержке ООО «Альфасигма Рус».</funding-statement><funding-statement xml:lang="en">The work was supported by “Alfasigma Rus” LLC.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Шелыгин Ю.А., Ачкасов С.И., Васильев С.В., Григорьев Е.Г., Дудка В.В. и др. Рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению взрослых больных дивертикулярной болезнью ободочной кишки. Рос журн гастроэнтерол гепатол колопроктол. 2016;26(1):65–80.</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Shelygin Yu.A., Achkasov S.I., Vasilyev S.V., Grigoryev Ye.G., Dudka V.V., et al. Diagnostics and treatment of diverticular disease of the colon: guidelines of the Russian gastroenterological Association and Russian Association of Coloproctology. Russ J Gastroenterol Hepatol Coloproctol. 2016;26(1):65–80 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tursi A. A critical appraisal of advances in the diagnosis of diverticular disease. Expert Rev Gastroenterol Hepatol. 2018;12(8):791–96 DOI: 10.1080/17474124.2018.1487288</mixed-citation><mixed-citation xml:lang="en">Tursi A. A critical appraisal of advances in the diagnosis of diverticular disease. Expert Rev Gastroenterol Hepatol. 2018;12(8):791–96 DOI: 10.1080/17474124.2018.1487288</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tursi A. Diverticulosis today: unfashionable and still under-researched. Therap Adv Gastroenterol. 2016;9(2):213–28. DOI: 10.1177/1756283X15621228</mixed-citation><mixed-citation xml:lang="en">Tursi A. Diverticulosis today: unfashionable and still under-researched. Therap Adv Gastroenterol. 2016;9(2):213–28. DOI: 10.1177/1756283X15621228</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zaidi E., Daly B. CT and clinical features of acute diverticulitis in an urban US population: rising frequency in young, obese adults. Am J Roentgenology. 2006;187(3):689–94. DOI: 10.2214/AJR.05.0033. PMID: 16928931</mixed-citation><mixed-citation xml:lang="en">Zaidi E., Daly B. CT and clinical features of acute diverticulitis in an urban US population: rising frequency in young, obese adults. Am J Roentgenology. 2006;187(3):689–94. DOI: 10.2214/AJR.05.0033. PMID: 16928931</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Schweitzer J., Casillas R.A., Collins J.C. Acute diverticulitis in the young adult is not “virulent”. Am Surg. 2002;68(12):1044–7.</mixed-citation><mixed-citation xml:lang="en">Schweitzer J., Casillas R.A., Collins J.C. Acute diverticulitis in the young adult is not “virulent”. Am Surg. 2002;68(12):1044–7.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Guzzo J., Hyman N. Diverticulitis in young patients: is resection after a single attack always warranted? Dis Colon Rectum. 2004;47(7):1187–90; discussion 1190–1. DOI: 10.1007/s10350-004-0546-7</mixed-citation><mixed-citation xml:lang="en">Guzzo J., Hyman N. Diverticulitis in young patients: is resection after a single attack always warranted? Dis Colon Rectum. 2004;47(7):1187–90; discussion 1190–1. DOI: 10.1007/s10350-004-0546-7</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen G.C., Sam J., Anand N. Epidemiological trends and geographic variation in hospital admissions for diverticulitis in the United States. World J Gastroenterol. 2011;17(12):1600–5. DOI: 10.3748/wjg.v17.i12.1600</mixed-citation><mixed-citation xml:lang="en">Nguyen G.C., Sam J., Anand N. Epidemiological trends and geographic variation in hospital admissions for diverticulitis in the United States. World J Gastroenterol. 2011;17(12):1600–5. DOI: 10.3748/wjg.v17.i12.1600</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Etzioni D.A., Mack T.M., Beart R.W., Kaiser A.M. Diverticulitis in the United States: 1998–2005: changing patterns of disease and treatment. Ann Surg. 2009;249(2):210–7. DOI: 10.1097/SLA.0b013e3181952888</mixed-citation><mixed-citation xml:lang="en">Etzioni D.A., Mack T.M., Beart R.W., Kaiser A.M. Diverticulitis in the United States: 1998–2005: changing patterns of disease and treatment. Ann Surg. 2009;249(2):210–7. DOI: 10.1097/SLA.0b013e3181952888</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cuomo R., Barbara G., Andreozzi P., Bassotti G., Casetti T., Grassini M., et al. Symptom patterns can distinguish diverticular disease from irritable bowel syndrome. Eur J Clin Invest. 2013;43(11):1147–55. DOI: 10.1111/eci.12152</mixed-citation><mixed-citation xml:lang="en">Cuomo R., Barbara G., Andreozzi P., Bassotti G., Casetti T., Grassini M., et al. Symptom patterns can distinguish diverticular disease from irritable bowel syndrome. Eur J Clin Invest. 2013;43(11):1147–55. DOI: 10.1111/eci.12152</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Шифрин О.С., Полуэктова Е.А., Королев А.В., Семенова Т.И., Шеин М.В., Лексикова Г.Н. и др. Российское неинтервенционное исследование эффективности и переносимости терапии рифаксимином-α у пациентов с неосложненной формой дивертикулярной болезни в условиях амбулаторной практики. Рос журн гастроэнтерол гепатол колопроктол. 2020;30(1):14–25.</mixed-citation><mixed-citation xml:lang="en">Shifrin O.S., Poluektova E.A., Korolev A.V., Semenova T.I., Shein M.V., Leksikova G.N., et al. Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Practice. Russ J Gastroenterol Hepatol Coloproctol. 2020;30(1):14–25 (In Russ.)]. DOI: 10.22416/1382-4376-2020-30-1-14-25</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bianchi M., Festa V., Moretti A., Ciaco A., Mangone M., Tornatore V., et al. Meta-analysis: long-term therapy with rifaximin in the management of uncomplicated diverticular disease. Aliment Pharmacol Ther. 2011;33(8):902–10.DOI: 10.1111/j.1365-2036.2011.04606.x</mixed-citation><mixed-citation xml:lang="en">Bianchi M., Festa V., Moretti A., Ciaco A., Mangone M., Tornatore V., et al. Meta-analysis: long-term therapy with rifaximin in the management of uncomplicated diverticular disease. Aliment Pharmacol Ther. 2011;33(8):902–10.DOI: 10.1111/j.1365-2036.2011.04606.x</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Stallinger S., Eller N., Högenauer C. Non-interventional study evaluating efficacy and tolerability of rifaximin for treatment of uncomplicated diverticular disease. Wien Klin Wochenschr. 2014;126(1–2):9–14. DOI: 10.1007/s00508-013-0447-7</mixed-citation><mixed-citation xml:lang="en">Stallinger S., Eller N., Högenauer C. Non-interventional study evaluating efficacy and tolerability of rifaximin for treatment of uncomplicated diverticular disease. Wien Klin Wochenschr. 2014;126(1–2):9–14. DOI: 10.1007/s00508-013-0447-7</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Strate L.L., Morris A.M. Epidemiology, Pathophysiology, and Treatment of Diverticulitis. Gastroenterology. 2019;156(5):1282–98. DOI: 10.1053/j.gastro.2018.12.033</mixed-citation><mixed-citation xml:lang="en">Strate L.L., Morris A.M. Epidemiology, Pathophysiology, and Treatment of Diverticulitis. Gastroenterology. 2019;156(5):1282–98. DOI: 10.1053/j.gastro.2018.12.033</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang Z.D., Ke S., Palazzini E., Riopel L., Dupont H. In vitro activity and fecal concentration of rifaximin after oral administration. Antimicrob Agents Chemother. 2000;44(8):2205–06. DOI: 10.1128/aac.44.8.2205-2206.2000</mixed-citation><mixed-citation xml:lang="en">Jiang Z.D., Ke S., Palazzini E., Riopel L., Dupont H. In vitro activity and fecal concentration of rifaximin after oral administration. Antimicrob Agents Chemother. 2000;44(8):2205–06. DOI: 10.1128/aac.44.8.2205-2206.2000</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Maccaferri S., Vitali B., Klinder A., Kolida S., Ndagijimana M., Laghi L., et al. Rifaximin modulates the colonic microbiota of patients with Crohn’s disease: an in vitro approach using a continuous culture colonic model system. J Antimicrob Chemother. 2010;65(12):2556–65. DOI: 10.1093/jac/dkq345</mixed-citation><mixed-citation xml:lang="en">Maccaferri S., Vitali B., Klinder A., Kolida S., Ndagijimana M., Laghi L., et al. Rifaximin modulates the colonic microbiota of patients with Crohn’s disease: an in vitro approach using a continuous culture colonic model system. J Antimicrob Chemother. 2010;65(12):2556–65. DOI: 10.1093/jac/dkq345</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Longo S.A., Moore R.C., Canzoneri B.J., Robichaux A. Gastrointestinal Conditions during Pregnancy. Clinics in Colon and Rectal Surgery. 2010;23(2):80–9. DOI: 10.1055/s-0030-1254294</mixed-citation><mixed-citation xml:lang="en">Longo S.A., Moore R.C., Canzoneri B.J., Robichaux A. Gastrointestinal Conditions during Pregnancy. Clinics in Colon and Rectal Surgery. 2010;23(2):80–9. DOI: 10.1055/s-0030-1254294</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
