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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2020-30-1-49-70</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-465</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Диагностика и лечение язвенной болезни у взрослых (Клинические рекомендации Российской гастроэнтерологической ассоциации, Российского общества колоректальных хирургов и Российского эндоскопического общества)</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and Treatment of Peptic Ulcer in Adults (Clinical Guidelines of the Russian Gastroenterological Association, Russian Society of Colorectal Surgeons and the Russian Endoscopic Society)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6815-6015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">kont07@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>RAS Academician, Dr. Sci. (Med.), Prof., Departmental Head, Department of Internal Disease Propaedeutics and Gastroenterology</p><p>127473, Moscow, Delegatskaya str., 20, building 1 </p></bio><email xlink:type="simple">igormaev@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Царьков</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsar’kov</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Director, Clinic for Coloproctology and Minimally Invasive Surgery, University Clinical Hospital No. 2</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><email xlink:type="simple">tsarkovpetr@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королев</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Korolev</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, заведующий кафедрой общей хирургии с курсом эндоскопии </p><p>119014, г. Санкт-Петербург, Литейный проспект, д. 56 </p></bio><bio xml:lang="en"/><email xlink:type="simple">korolevmp@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreev</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Cand. Sci. (Med.), Research Assistant, Department of Internal Disease Propedeutics and Gastroenterology</p><p>127473, Moscow, Delegatskaya str., 20, building 1 </p></bio><email xlink:type="simple">dna-mit8@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранская</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranskaya</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Department of Internal Disease Propaedeutics</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><email xlink:type="simple">ebaranskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурков</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Burkov</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">bourk@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деринов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Derinov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">alexandr.derinov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефетов</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Efetov</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Cand. Sci. (Med.), Ass. Prof., Department of Surgery, Institute of Clinical Medicine</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><email xlink:type="simple">efetov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4456-8725</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапина</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapina</surname><given-names>T. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, кафедра пропедевтики внутренних болезней лечебного факультета </p><p>119991, г. Москва, ул. Погодинская, д. 1, стр. 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Department of Internal Disease Propaedeutics</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><email xlink:type="simple">tatlapina@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, заведующий отделением диагностической и лечебной эндоскопии Университетской клинической больницы № 2 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Министерства здравоохранения Российской Федерации</p><p>119991, г. Москва, ул. Погодинская, д. 1, стр. 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Departmental Head, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><email xlink:type="simple">pvpavlov@yandex.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8101-2155</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирогов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pirogov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Dr. Sci. (Med.), Departmental Head, Endoscopy Department</p><p>125284, Moscow, 2nd Botkinsky pr., 3 </p></bio><email xlink:type="simple">pirogov@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Doc. Sci. (Med.), Prof., Departmental Head, Department of Internal Diseases Propaedeutics</p><p>344022, Rostov-on-Don, Nakhichevansky per., 29 </p></bio><email xlink:type="simple">tkachev@aaanet.ru</email><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3362-2968</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трухманов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhmanov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Department of Internal Disease Propaedeutics</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><email xlink:type="simple">alexander.trukhmanov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федоров</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorov</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">efedo@mail.ru</email><xref ref-type="aff" rid="aff-9"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1395-9566</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шептулин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheptulin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней лечебного факультета </p><p>119991, г. Москва, ул. Погодинская, д. 1, стр. 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., Department of Internal Disease Propaedeutics</p><p>119991, Moscow, Pogodinskaya str., 1, building 1 </p></bio><xref ref-type="aff" rid="aff-10"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State Paediatric Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Поликлиника № 3 Управления делами при Президенте Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Polyclinic No. 3 of the Administrative Department of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff xml:lang="en" id="aff-6"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр радиологии им. П.А. Герцена — филиала ФГБУ «Московский научно-исследовательский онкологический институт» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.A. Gertsen National Medical Research Centre for Radiology, branch of the Moscow Research Institute of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>ФГАOУ ВО «Российский национальный исследовательский университет им. Н.И. Пирогова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov National Research University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-10"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет&#13;
им. И.М. Сеченова» (Сеченовский университет) Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>08</day><month>04</month><year>2020</year></pub-date><volume>30</volume><issue>1</issue><fpage>49</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Маев И.В., Царьков П.В., Королев М.П., Андреев Д.Н., Баранская Е.К., Бурков С.Г., Деринов А.А., Ефетов С.К., Лапина Т.Л., Павлов П.В., Пирогов С.С., Ткачев А.В., Трухманов А.С., Федоров Е.Д., Шептулин А.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Маев И.В., Царьков П.В., Королев М.П., Андреев Д.Н., Баранская Е.К., Бурков С.Г., Деринов А.А., Ефетов С.К., Лапина Т.Л., Павлов П.В., Пирогов С.С., Ткачев А.В., Трухманов А.С., Федоров Е.Д., Шептулин А.А.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Maev I.V., Tsar’kov P.V., Korolev M.P., Andreev D.N., Baranskaya E.K., Burkov S.G., Derinov A.A., Efetov S.K., Lapina T.L., Pavlov P.V., Pirogov S.S., Tkachev A.V., Trukhmanov A.S., Fedorov E.D., Sheptulin A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/465">https://www.gastro-j.ru/jour/article/view/465</self-uri><abstract><p>Цель представления клинических рекомендаций, предназначенных для врачей-гастроэнтерологов, врачей общей практики (семейных врачей), врачей-терапевтов, заключается в изложении современных методов диагностики и лечения язвенной болезни.</p><sec><title>Основное содержание</title><p>Основное содержание. Язвенная болезнь (ЯБ) представляет собой хроническое рецидивирующее  заболевание, протекающее с чередованием периодов обострения и ремиссии, ведущим проявлением которого служит образование дефекта (язвы) в стенке желудка и двенадцатиперстной кишки. Большинство случаев ЯБ патогенетически связано с инфекцией Н. pylori. Различают ЯБ как самостоятельное заболевание и симптоматические язвы желудка и двенадцатиперстной кишки (лекарственные, «стрессовые», при эндокринной патологии, при других хронических заболеваниях внутренних органов). Всем пациентам с подозрением на ЯБ, при отсутствии противопоказаний, с целью подтверждения диагноза рекомендуется проведение эзофагогастродуоденоскопии. Всем пациентам с ЯБ с целью определения показаний к эрадикационной терапии рекомендуется проведение тестирования на наличие инфекции Н. рylori с помощью 13С-дыхательного теста или определения антигена H. pylori в кале, а при одновременном проведении ЭГДС — с помощью быстрого уреазного теста. Всем пациентам с ЯБ с положительными результатами тестирования на инфекцию H. рylori с целью профилактики последующих рецидивов ЯБ рекомендуется проведение эрадикационной терапии, с целью достижения заживления язв рекомендуется проведение антисекреторной терапии ингибиторами протонного насоса в течение 4–6 недель. Клинические рекомендации содержат критерии оценки качества оказания медицинской помощи, алгоритм действия врача, а также информацию для пациента.</p></sec><sec><title>Заключение</title><p>Заключение. В клинических рекомендациях даются современные представления об этиологии и патогенезе язвенной болезни, ее клинических проявлениях, методах лабораторной и инструментальной диагностики, основных подходах к консервативному и хирургическому лечению.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. These clinical recommendations present up-to-date methods for the diagnosis and treatment of peptic ulcer. The recommendations are intended for gastroenterologists and general practitioners.</p></sec><sec><title>General provisions</title><p>General provisions. Peptic ulcer (PU) represents a chronic relapsing disease occurring with alternating periods of exacerbation and remission. The main manifestation of the disease is the formation of a defect (ulcer) in the wall of the stomach and duodenum. Most cases of peptic ulcer are pathogenetically associated with the infection of H. pylori. PU can be an independent disease or represent symptomatic ulcers of the stomach and duodenum (medicinal, as a result of stress or endocrine pathologies, associated with chronic diseases of internal organs). In the absence of contraindications, esophagogastroduodenoscopy is recommended for all patients with suspected ulcer with the purpose of confirming the diagnosis. In order to determine indications for eradication therapy, all ulcer patients should be tested for the presence of H. pylori using a 13C-breath test or a stool antigen test. In the case of simultaneous endoscopy, rapid urease test can be used. For the prevention of subsequent relapses of ulcer, all PU patients with confirmed H. pylori should undergo eradication therapy. In addition, in order to achieve ulcer healing, 4–6 week antisecretory therapy with proton pump inhibitors is recommended. Clinical recommendations contain criteria for assessing the quality of medical care, an algorithm of the doctor’s actions, as well as information for patients.</p></sec><sec><title>Conclusions</title><p>Conclusions. These clinical recommendations present modern ideas about the etiology and pathogenesis of peptic ulcer disease, its clinical manifestations, methods of laboratory and instrumental diagnostics and basic approaches to conservative and surgical treatment. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>язвенная болезнь</kwd><kwd>язвенное кровотечение</kwd><kwd>перфорация</kwd><kwd>стеноз</kwd><kwd>H. pylori</kwd><kwd>эрадикационная терапия H. pylori</kwd><kwd>ингибиторы протонной помпы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>peptic ulcer</kwd><kwd>peptic ulcer bleeding</kwd><kwd>perforation</kwd><kwd>stenosis</kwd><kwd>H. pylori</kwd><kwd>H. pylori eradication therapy</kwd><kwd>proton pump inhibitors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shay H., Sun D.C.H. Etiology and pathology of gastric and duodenal ulcer. In: Bockus H.L. 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