gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2020-30-6-40-44gastro-j-506Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL ARTICLESРоль совместного влияния полиморфизма rs1799930 гена NAT2-590 G>A и употребления алкоголя в развитии острого панкреатитаMutual Effect of NAT2 rs1799930 (590G>A) Polymorphism and Alcohol Abuse on Risk of Acute Pancreatitishttps://orcid.org/0000-0002-7781-3793СамгинаТ. А.SamginaT. A.

Самгина Татьяна Александровна — кандидат медицинских наук, доцент кафедры хирургических болезней № 2

305000, г. Курск, ул. Карла Маркса, д. 3

Tatyana A. Samgina — Cand. Sci. (Med.), Assoc. Prof., Department of Surgical Diseases No. 2

305000, Kursk, Karla Marksa str., 3

tass@list.ruФГБОУ ВО «Курский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKursk State Medical UniversityRussian Federation2020311220203064044Copyright © Самгина Т.А., 20202020Самгина Т.А.Samgina T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/506

Цель: определить вклад полиморфизма rs1799930 гена NAT2-590 G>A в развитие острого алкогольного панкреатита.Материалы и методы. Образцы ДНК получены от 547 неродственных больных острым алкогольным панкреатитом и 573 неродственных индивидов без заболеваний желудочно-кишечного тракта. По результатам анкетирования выявлены лица, употреблявшие алкоголь более 200 мл в пересчете на этанол в неделю; 2 раза в неделю и более; с длительностью употребления алкоголя 10 лет и более. Генотипирование выполнено с помощью метода ПЦР с дискриминацией аллелей с помощью TaqMan-зондов.Результаты. Ассоциаций изучаемого полиморфизма гена с риском развития острого алкогольного панкреатита не обнаружено, ассоциации полиморфизма rs1799930 гена NAT2-590 G>A с длительностью и частотой употребления алкоголя не обнаружено. Генотип G>A полиморфизма rs1799930 гена NAT2-590 G>A при употреблении алкоголя более 200 г в пересчете на этанол в неделю обладал повышенным риском развития острого алкогольного панкреатита (отношение шансов 2,16; 95 % доверительный интервал 1,13–4,12).Заключение. Полиморфизм G/Ars1799930 гена NAT2-590 повышал риск развития ОП при употреблении алкогольных напитков более 200 г этанола в неделю.

Aim. Estimation of the contribution of rs1799930 (590G>A) polymorphism of gene NAT2 to the development of acute alcoholic pancreatitis.Materials and methods. DNA samples were obtained from 547 unrelated patients with acute alcoholic pancreatitis and 573 unrelated individuals without gastrointestinal diseases. A survey selected individuals with the alcohol consumption of >200 g/week pure ethanol two times a week or more during 10 or more years. Genotyping was performed with PCR using TaqMan allelic discrimination assays.Results. No association was observed between the NAT2 allelic rs1799930 (590G>A) polymorphism, risk of acute alcoholic pancreatitis, duration and rate of alcohol consumption. The 590G>A variant of rs1799930 in gene NAT2 correlated with an increased risk of acute alcoholic pancreatitis (odds ratio 2.16; 95% confidence interval 1.13–4.12) under alcohol consumption >200 g/week pure ethanol.Conclusion. The rs1799930 G/A polymorphism of gene NAT2 increases the risk of acute pancreatitis under alcohol consumption >200 g/week pure ethanol.

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The authors declare that there are no conflicts of interest present.