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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2022-32-1-7-14</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-655</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Воспаление, нарушение моторной функции и висцеральная гиперчувствительность: основные механизмы функциональных расстройств желудочно-кишечного тракта (обзор литературы и резолюция Совета Экспертов)</article-title><trans-title-group xml:lang="en"><trans-title>Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6815-6015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивашкин Владимир Трофимович — доктор медицинских наук, академик РАН, профессор, заведующий кафедрой пропедевтики внутренних болезней; директор клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологиии.</p><p>119435, Москва, ул. Погодинская, д. 1, стр. 1.</p></bio><bio xml:lang="en"><p>Vladimir T. Ivashkin — Dr. Sci. (Med.), RAS Academician, Prof., Head of the Department of the Propedeutics of Internal Diseases, Head of the V.H. Vasilenko Clinic of the Propedeutis of Internal Diseases, Gastroenterology and Hepatology, I.V. Sechenov First Moscow State Medical University (Sechenov University).</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1.</p></bio><email xlink:type="simple">ivashkin_v_t@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6114-564X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маев Игорь Вениаминович — доктор медицинских наук, академик РАН, профессор, заведующий кафедрой пропедевтики внутренних болезней и гастроэнтерологии.</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1.</p></bio><bio xml:lang="en"><p>Igor V. Maev — Dr.  Sci.  (Med.),  RAS  Academician.  Professor, Head of the Department of Propedeutics of Internal Disease and Gastroenterology, A.E. Yevdokimov Moscow State University of Medicine and Dentistry.</p><p>127473, Moscow, Delegatskaya str., 20, build. 1.</p></bio><email xlink:type="simple">igormaev@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3362-2968</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трухманов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhmanov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трухманов Александр Сергеевич — доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии.</p><p>119435, Москва, ул. Погодинская, д. 1, стр. 1.</p></bio><bio xml:lang="en"><p>Alexander S. Trukhmanov — Dr. Sci. (Med.), Professor, Department of Internal Disease Propedeutics, I.M. Sechenov First Moscow State Medical University (Sechenov University).</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1.</p></bio><email xlink:type="simple">trukhmanov_a_s@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1395-9566</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шептулин</surname><given-names>А. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheptulin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шептулин Аркадий Александрович — доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии.</p><p>119435, Москва, ул. Погодинская, д. 1, стр. 1.</p></bio><bio xml:lang="en"><p>Arkadiy A. Sheptulin — Dr. Sci. (Med.), Professor, Department of Internal Disease Propedeutics, I.M. Sechenov First Moscow State Medical University (Sechenov University).</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1.</p></bio><email xlink:type="simple">arkalshep@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4456-8725</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапина</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapina</surname><given-names>T. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лапина Татьяна Львовна — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии.</p><p>119435, Москва, ул. Погодинская, д. 1, стр. 1.</p></bio><bio xml:lang="en"><p>Tatyana L. Lapina —  Cand.  Sci.  (Med.),  Assoc.  Prof.  Chair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University).</p><p>119435, Moscow, Pogodinskaya str., 1, bld. 1.</p></bio><email xlink:type="simple">lapina_t_l@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1956-0070</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симаненков</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Simanenkov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симаненков Владимир Ильич — доктор медицинских наук, профессор кафедры внутренних болезней, клинической фармакологии и нефрологии.</p><p>191015, Санкт-Петербург, ул. Кирочная, д. 41.</p></bio><bio xml:lang="en"><p>Vladimir I. Simanenkov — Dr. Sci. (Med.), Prof., Departament of Internal Diseases, Clinical Pharmacology and Nephrology, I.I. Mechnikov North-West State Medical University.</p><p>191015, St.-Petersburg, Kirochnaya str., 41.</p></bio><email xlink:type="simple">visimanenkov@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8358-3963</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколов</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolov</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколов Кирилл Александрович — врач — акушер-гинеколог, менеджер медицинских организаций, руководитель Медицинского и клинического отдела России, Украины и стран СНГ, «Байер Консьюмер Хэлс».</p><p>107113, Москва, 3-я Рыбинская ул., д. 18, корп. 2.</p></bio><bio xml:lang="en"><p>Kirill A. Sokolov — obstetrician-gynecologist, manager of medical organizations, Head of the Medical and Clinical Department in Russia, Ukraine and the CIS countries, Bayer Consumer Health.</p><p>107113, Moscow, 3rd Rybinskaya str., 18, build. 2.</p></bio><email xlink:type="simple">kirill.sokolov@bayer.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный университет им. И.М. Сеченова (Сеченовский Университет) Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Северо-Западный государственный медицинский университет имени И.И. Мечникова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mechnikov North-Western State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>АО «Байер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>“Bayer” JSC</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>07</day><month>03</month><year>2022</year></pub-date><volume>32</volume><issue>1</issue><fpage>7</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Маев И.В., Трухманов А.С., Шептулин А.A., Лапина Т.Л., Симаненков В.И., Соколов К.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Маев И.В., Трухманов А.С., Шептулин А.A., Лапина Т.Л., Симаненков В.И., Соколов К.А.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Maev I.V., Trukhmanov A.S., Sheptulin A.A., Lapina T.L., Simanenkov V.I., Sokolov K.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/655">https://www.gastro-j.ru/jour/article/view/655</self-uri><abstract><sec><title>Цель публикации</title><p>Цель публикации. Рассмотреть основные механизмы функциональных расстройств желудочно-кишечного тракта и представить материалы Совета Экспертов, который состоялся 10 декабря 2021 г. в Москве.</p></sec><sec><title>Основные положения</title><p>Основные положения. Патогенез наиболее частых функциональных заболеваний желудочно-кишечного</p><p>тракта (ЖКТ) — функциональной диспепсии (ФД) и синдрома раздраженного кишечника (СРК) — является многофакторным и включает в себя нарушения моторики различных отделов ЖКТ, висцеральную гиперчувствительность, изменения кишечного микробиома, нарушения проницаемости защитного барьера, воспаление слизистой оболочки ЖКТ низкой степени активности и др. Нередко это приводит к назначению таким больным комплекса различных лекарственных препаратов, что повышает риск возникновения нежелательного лекарственного взаимодействия и побочных эффектов. Мультитаргетная терапия предполагает применение препаратов, одновременно влияющих на разные патогенетические звенья. Одним из таких препаратов является Иберогаст®, нормализующий моторику ЖКТ и висцеральную чувствительность, обладающий противовоспалительным действием и оказывающийся высокоэффективным в лечении ФД и СРК.</p></sec><sec><title>Выводы</title><p>Выводы. В лечении функциональных заболеваний ЖКТ, характеризующихся многофакторностью патогенеза, следует отдавать предпочтение мультитаргетной терапии с назначением препаратов, влияющих на его разные звенья.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To review the main mechanisms of functional disorders of the gastrointestinal tract and to present the materials of an Expert Council, which was held on 10 December 2021 in Moscow.</p></sec><sec><title>Key points</title><p>Key points. The pathogenesis of the most common functional diseases of the gastrointestinal tract — functional dyspepsia (FD) and irritable bowel syndrome (IBS) is multifactorial and includes motor disorders of various parts of the gastrointestinal tract, visceral hypersensitivity, changes in the intestinal microbiome, impairment of the permeability of the protective barrier, low-grade inflammation of the gastrointestinal mucosa, etc. This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. One of these drugs is Iberogast®, which normalizes gastrointestinal motility and visceral sensitivity, has an anti-inflammatory action and is highly effective in treatment of FD and IBS.</p></sec><sec><title>Conclusion</title><p>Conclusion. In the treatment of functional gastrointestinal diseases characterized by multifactorial pathogenesis, preference should be given to multi-targeted therapy with the use of drugs that have an effect on its various links.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>желудочно-кишечный тракт</kwd><kwd>моторика</kwd><kwd>висцеральная гиперчувствительность</kwd><kwd>воспаление</kwd><kwd>Иберогаст®</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastrointestinal tract</kwd><kwd>motility</kwd><kwd>visceral hypersensitivity</kwd><kwd>inflammation</kwd><kwd>Iberogast®</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Экспертный совет состоялся при организационной поддержке фармацевтической компании «Байер».</funding-statement><funding-statement xml:lang="en">The Expert Council was held under the technical support of the «Bayer» pharmaceutical company.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Маев И.В., Шептулин А.А., Лапина Т.Л., Трухманов А.С., Картавенко И.М. и др. 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