gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2022-32-5-75-88gastro-j-711Research ArticleНАЦИОНАЛЬНАЯ ШКОЛА ГАСТРОЭНТЕРОЛОГИИ, ГЕПАТОЛОГИИNATIONAL COLLEGE OF GASTROENTEROLOGY, HEPATOLOGYРоль кишечной микробиоты и ее метаболитов в патогенезе неалкогольной жировой болезни печениGut Microbiota and its Metabolites in Pathogenesis of NAFLDhttps://orcid.org/0000-0001-9276-6924РешетоваМ. С.ReshetovaM. S.

Решетова Мария Сергеевна — аспирант кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии лечебного факультета

119435, г. Москва, ул. Погодинская, д. 1, стр. 1

Maria S. Reshetova — graduate student, Deprtament of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, bld. 1

maria.reshetova@icloud.comhttps://orcid.org/0000-0002-6701-789XЗольниковаО. Ю.ZolnikovaO. Yu.

Зольникова Оксана Юрьевна — доктор медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии лечебного факультета

119435, г. Москва, ул. Погодинская, д. 1, стр. 1

Oxana Yu. Zolnikova — Dr. Sci. (Med.), Associate Prof., Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, bld. 1

ks.med@mail.ruhttps://orcid.org/0000-0002-6815-6015ИвашкинВ. Т.IvashkinV. T.

Ивашкин Владимир Трофимович — доктор медицинских наук, профессор, академик РАН, заведующий кафедрой пропедевтики внутренних болезней, гастроэнтерологии и гепатологии лечебного факультета

119435, г. Москва, ул. Погодинская, д. 1, стр. 1

Vladimir T. Ivashkin — Dr. Sci. (Med.), RAS Academician, Prof., Department Head, Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, bld. 1

kont07@yandex.ruhttps://orcid.org/0000-0002-5699-541XИвашкинК. В.IvashkinK. V.

Ивашкин Константин Владимирович — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии лечебного факультета

119435, г. Москва, ул. Погодинская, д. 1, стр. 1

Konstantin V. Ivashkin — Cand. Sci. (Med.), Associate Prof., Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, bld. 1

2135833@mail.ruhttps://orcid.org/0000-0002-9032-1558АпполоноваС. А.AppolonovaS. A.

Апполонова Светлана Александровна — кандидат химических наук, доцент кафедры фармакологии Института фармации им. А.П. Нелюбина ; заведующая лабораторией фармакокинетики и метаболомного анализа Института трансляционной медицины и биотехнологии 

119435, г. Москва, ул. Погодинская, д. 1, стр. 1

Svetlana A. Appolonova — Cand. Sci. (Chemistry), Associate Prof., Department of Pharmacology, Institute of Pharmacy named after A.P. Nelyubina, Head of the Laboratory of Pharmacokinetics and Metabolomic Analysis of the Institute of Translational Medicine and Biotechnology

119435, Moscow, Pogodinskaya str., 1, bld. 1

appolonova_s_a@staff.sechenov.ruhttps://orcid.org/0000-0003-4456-8725ЛапинаТ. Л.LapinaT. L.

Лапина Татьяна Львовна — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии лечебного факультета

119435, г. Москва, ул. Погодинская, д. 1, стр. 1

Tatiana L. Lapina — Cand. Sci. (Med.), Associate Prof., Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, bld. 1

tatlapina@gmail.comФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский Университет) Министерства здравоохранения Российской ФедерацииSechenov First Moscow State Medical University (Sechenov University)2022080120233257588Copyright © Решетова М.С., Зольникова О.Ю., Ивашкин В.Т., Ивашкин К.В., Апполонова С.А., Лапина Т.Л., 20232023Решетова М.С., Зольникова О.Ю., Ивашкин В.Т., Ивашкин К.В., Апполонова С.А., Лапина Т.Л.Reshetova M.S., Zolnikova O.Y., Ivashkin V.T., Ivashkin K.V., Appolonova S.A., Lapina T.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/711Цель обзора

Цель обзора: представить информацию о результатах последних научных исследований в области метаболомного профилирования при неалкогольной жировой болезни печени (НАЖБП).

Основные положения

Основные положения. Метаболиты микробного происхождения являются важными биологическими молекулами, участвующими во многих специфических реакциях организма человека. В данном обзоре литературы представлены результаты последних исследований в области метаболомики у пациентов с НАЖБП. Более детальное понимание роли отдельно взятых метаболитов или же их совокупности в патогенезе НАЖБП позволит определить вектор дальнейших диагностических и терапевтических подходов для этой нозологии.

Обсуждаются результаты исследований влияния пробиотиков на уровень тех или иных метаболитов.

Заключение

Заключение. Представлены новые данные исследований в области изучения метаболомного профиля человека. Результаты позволяют суммировать эффекты микробных агентов и их метаболитов в процессе формирования изменений паренхимы печени в рамках НАЖБП. Описаны изменения уровня эндогенного этанола, вторичных желчных кислот, ароматических аминокислот, аминокислот с разветвленной цепью и пр. Выявлена корреляция метаболитов с определенными штаммами бактерий. На фоне приема пробиотиков отмечена корреляция соотношения типов бактерий и клинико-лабораторных показателей у пациентов.

Aim

Aim: to provide information on the results of recent scientific research in the field of non-alcoholic fatty liver disease (NAFLD) metabolomic profiling.

Key points

Key points. Metabolites of microbial origin are important biological molecules involved in many specific reactions of the human body. This literature review presents the results of recent studies in the field of metabolomics in patients with NAFLD. A more detailed understanding of the role of individual metabolites or their combinations in the NAFLD pathogenesis will allow us to determine the vector of further diagnostic and therapeutic approaches for this nosology. The research results of the probiotics effect on the levels of certain metabolites are currently being discussed.

Conclusion

Conclusion. New research data in the field of studying the human metabolomic profile are presented. The results allow us to summarize the effects of microbial agents and their metabolites in the formation of changes in the liver parenchyma in the context of NAFLD. Changes in the level of endogenous ethanol, secondary bile acids, aromatic amino acids, branched chain amino acids, etc. have been described. Correlation between metabolites and certain bacterial strains has been established. A correlation between the ratio of bacteria types and clinical/laboratory parameters was noted in patients taking prebiotics.

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The authors declare that there are no conflicts of interest present.