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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2024-34-1-58-69</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-831</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАЦИОНАЛЬНАЯ ШКОЛА ГАСТРОЭНТЕРОЛОГИИ, ГЕПАТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NATIONAL COLLEGE OF GASTROENTEROLOGY, HEPATOLOGY</subject></subj-group></article-categories><title-group><article-title>Аутоиммунный гастрит: в фокусе эндоскопические и морфологические характеристики</article-title><trans-title-group xml:lang="en"><trans-title>Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5685-8784</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирюхин</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiryukhin</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кирюхин Андрей Павлович — кандидат медицинских наук, врач-эндоскопист отделения диагностической и лечебной эндоскопии Университетской клинической больницы № 2 </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Andrey P. Kiryukhin — Cand. Sci. (Med.), Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">a.p.kiryukhin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5635-6100</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тертычный</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tertychnyy</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тертычный Александр Семенович — доктор медицинских наук, профессор, заведующий лабораторией электронной микроскопии и иммуногистохимии Института клинической морфологии и цифровой патологии </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Alexander S. Tertychnyy — Dr.   Sci.   (Med.),   Professor, Head of the Laboratory of Electron Microscopy and Immunohistochemistry, Institute of Clinical Morphology and Digital Pathology</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">atertychnyy@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4391-5441</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павлов Павел Владимирович — кандидат медицинских наук, заведующий отделением диагностической и лечебной эндоскопии Университетской клинической больницы № 2 </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Pavel V. Pavlov — Cand. Sci. (Med.), Head of the Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">pvpavlov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1792-5638</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федоренко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Федоренко Александр Алексеевич — врач-эндоскопист отделения диагностической и лечебной эндоскопии Университетской клинической больницы № 2 </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Alexandr    A.    Fedorenko    —   Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">shyra10@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5907-6195</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нагорная</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nagornaya</surname><given-names>D. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нагорная Дарина Павловна — аспирант Института клинической морфологии и цифровой патологии </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Darina P. Nagornaya — Postgraduate, Institute of Clinical Morphology and Digital Pathology</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">ndp.msk@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4391-9776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маренич</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Marenich</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маренич Наталья Сергеевна — врач-эндоскопист эндоскопического отделения </p><p>119049, г. Москва, 4-й Добрынинский пер., 1/9</p></bio><bio xml:lang="en"><p>Natalia S. Marenich — Endoscopist of the Endoscopy Department</p><p>119049, Moscow, 4th Dobryninskiy lane, 1/9</p></bio><email xlink:type="simple">nataliamarenich@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3528-7983</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лосик</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Losik</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лосик Екатерина Александровна — кандидат медицинских наук, врач-кардиолог Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Ekaterina A. Losik — Cand. Sci. (Med.), Cardiologist, Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology named after V.Kh. Vasilenko</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">kollezion@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0131-3063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрьева</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Yuryeva</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрьева Елена Юрьевна — заведующая отделением гастроэнтерологии Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Elena Yu. Yuryeva — Head of the Department of Gastroenterology, Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology named after V.Kh. Vasilenko</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">doctorlena97@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4456-8725</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапина</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapina</surname><given-names>T. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лапина Татьяна Львовна — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии </p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Tatiana L. Lapina — Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">tatlapina@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский  университет  им.  И.М.  Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ города Москвы «Морозовская детская городская клиническая больница Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Morozov Children's City Clinical Hospital of the Moscow Health Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>22</day><month>02</month><year>2024</year></pub-date><volume>34</volume><issue>1</issue><fpage>58</fpage><lpage>69</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кирюхин А.П., Тертычный А.С., Павлов П.В., Федоренко А.А., Нагорная Д.П., Маренич Н.С., Лосик Е.А., Юрьева Е.Ю., Лапина Т.Л., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кирюхин А.П., Тертычный А.С., Павлов П.В., Федоренко А.А., Нагорная Д.П., Маренич Н.С., Лосик Е.А., Юрьева Е.Ю., Лапина Т.Л.</copyright-holder><copyright-holder xml:lang="en">Kiryukhin A.P., Tertychnyy A.S., Pavlov P.V., Fedorenko A.A., Nagornaya D.P., Marenich N.S., Losik E.A., Yuryeva E.Y., Lapina T.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/831">https://www.gastro-j.ru/jour/article/view/831</self-uri><abstract><sec><title>Цель</title><p>Цель: систематизировать литературные данные об эндоскопической семиотике и морфологических изменениях слизистой оболочки желудка при аутоиммунном гастрите.</p></sec><sec><title>Основные положения</title><p>Основные положения. Аутоиммунный гастрит ассоциирован с повышенным риском развития аденокарциномы и нейроэндокринных опухолей желудка. Уточнение диагностических критериев аутоиммунного гастрита имеет существенное значение для гастроэнтерологической практики. Установление диагноза основано на результатах эндоскопического и гистологического исследования, на данных лабораторных тестов. Изолированная атрофия слизистой оболочки тела желудка, наличие трудноотмываемой кремоподобной слизи, изменение слизистой оболочки по типу «сброшенной кожи», наличие белесых глобулоподобных очагов служат типичными эндоскопическими признаками аутоиммунного гастрита. Распространенная псевдопилорическая метаплазия, очаговая кишечная и псевдопанкреатическая метаплазия, гиперплазия валиков слизистой оболочки тела желудка и их соотношение к железистому слою как в антральном отделе позволяют при морфологическом исследовании с учетом клинических данных заподозрить и верифицировать аутоиммунный гастрит.</p></sec><sec><title>Заключение</title><p>Заключение. При инструментальном обследовании знание эндоскопических симптомов и патогномоничных морфологических изменений является важным для своевременного диагноза аутоиммунного гастрита. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: tosystematize the literature data on endoscopic semiotics and morphological changes in the gastric mucosa in autoimmune gastritis.</p></sec><sec><title>Key points</title><p>Key points. Autoimmune gastritis is associated with an increased risk of developing adenocarcinoma and neuroendocrine tumours of the stomach. Clarification of diagnostic criteria for autoimmune gastritis is essential for gastroenterological practice. The diagnosis is based on the results of endoscopic and histological examination, and on data from laboratory tests. Isolated atrophy of the mucous membrane of the body of the stomach, the presence of difficult-to-wash creamy mucus, changes in the mucous membrane like “shed skin”, and the presence of whitish globule-like foci are typical endoscopic signs of autoimmune gastritis. Widespread pseudopyloric metaplasia, focal intestinal and pseudopancreatic metaplasia, hyperplasia of the ridges of the mucous membrane of the body of the stomach and their relationship to the glandular layer as in the antrum allow during a morphological study considering clinical data to suspect and verify autoimmune gastritis.</p></sec><sec><title>Conclusion</title><p>Conclusion. During instrumental examination, knowledge of endoscopic symptoms and pathognomonic morphological changes is important for the timely diagnosis of autoimmune gastritis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>аутоиммунный гастрит</kwd><kwd>эндоскопия</kwd><kwd>биопсия</kwd><kwd>атрофия</kwd><kwd>Helicobacter pylori</kwd></kwd-group><kwd-group xml:lang="en"><kwd>autoimmune gastritis</kwd><kwd>endoscopy</kwd><kwd>biopsy</kwd><kwd>atrophy</kwd><kwd>Helicobacter pylori</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Uemura N., Okamoto S., Yamamoto S., Matsumura N., Yamaguchi S., Yamakido M., et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345(11):784–9. DOI: 10.1056/NEJMoa001999</mixed-citation><mixed-citation xml:lang="en">Uemura N., Okamoto S., Yamamoto S., Matsumura N., Yamaguchi S., Yamakido M., et al. 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