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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gastro-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гастроэнтерологии, гепатологии, колопроктологии</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Gastroenterology, Hepatology, Coloproctology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1382-4376</issn><issn pub-type="epub">2658-6673</issn><publisher><publisher-name>«Gastro» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22416/1382-4376-2023-33-5-41-53</article-id><article-id custom-type="elpub" pub-id-type="custom">gastro-j-868</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Пандемия COVID-19 и СРК. Результаты Всероссийской наблюдательной неинтервенционной программы изучения эффективности препарата Колофорт® в условиях реальной клинической практики у пациентов с синдромом раздраженного кишечника после перенесенной новой коронавирусной инфекции (ВЕСНА)</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19 Pandemic and IBS. Results of the All-Russian Observational Non-interventional Program to Study the Effectiveness of the Drug Kolofort® in Real Clinical Practice in Patients with Irritable Bowel Syndrome After a New Coronavirus Infection (VESNA)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6815-6015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивашкин Владимир Трофимович — доктор медицинских наук, профессор, академик РАН, заведующий кафедрой пропедевтики внутренних болезней, гастроэнтерологии и гепатологии, директор Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко</p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Vladimir T. Ivashkin — Dr. Sci. (Med.), Professor, Member of the Russian Academy of Sciences, Head of the Department of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Director</p><p>19435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">kont07@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1509-6776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдулхаков</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdulkhakov</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абдулхаков Рустем Аббасович — доктор медицинских наук, профессор, заслуженный врач Республики Татарстан, профессор кафедры госпитальной терапии лечебного факультета</p><p>420012, г. Казань, ул. Бутлерова, 49</p></bio><bio xml:lang="en"><p>Rustam A. Abdulkhakov — Dr. Sci. (Med.), Professor, Honored Doctor of the Republic of Tatarstan, Professor of the Department of Hospital Therapy of the Faculty of Medicine</p><p>420012, Kazan, Butlerova str., 49</p></bio><email xlink:type="simple">rustemabdul@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6151-2021</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бакулин</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakulin</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бакулин Игорь Геннадьевич — доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней, гастроэнтерологии и диетологии</p><p>191015, г. Санкт-Петербург, ул. Кирочная, 41</p></bio><bio xml:lang="en"><p>Igor G. Bakulin — Dr. Sci. (Med.), Professor, Head of the Department of Internal Diseases Propedeutics, Gastroenterology and Dietetics</p><p>191015, Saint-Petersburg, Kirochnaya str., 41</p></bio><email xlink:type="simple">igbakulin@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-1423-8338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaitsev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зайцев Сергей Вячеславович — заведующий Областным гастроэнтерологическим центром</p><p>150062, г. Ярославль, ул. Яковлевская, 7</p></bio><bio xml:lang="en"><p>Sergey V. Zaitsev — Head of the Regional Gastroenterological Center, Yaroslavl Regional Clinical Hospital, Chief Gastroenterologist of Yaroslavl Region</p><p>150062, Yaroslavl, Yakovlevskaya str., 7</p></bio><email xlink:type="simple">svzaytsev203071@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-1222-8048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лучина</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Luchina</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лучина Вероника Игоревна — врач-гастроэнтеролог</p><p>160012, г. Вологда, Советский просп., 94</p></bio><bio xml:lang="en"><p>Veronika I. Luchina — Gastroenterologist</p><p>160012, Vologda, Sovetskiy ave., 94</p></bio><email xlink:type="simple">nika011967@rambler.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7367-9219</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мехтиев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mekhtiyev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мехтиев Сабир Насрединович — доктор медицинских наук, профессор кафедры внутренних болезней</p><p>197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8</p></bio><bio xml:lang="en"><p>Sabir N. Mekhtiyev — Dr. Sci. (Med.), Professor of the Department of Internal Diseases, Academician</p><p>197022, Saint-Petersburg, L’va Tolstogo str., 6–8</p></bio><email xlink:type="simple">kosov_p@me.com</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-1614-8413</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пешехонов</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Peshekhonov</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пешехонов Сергей Георгиевич — кандидат медицинских наук, врач-гастроэнтеролог</p><p>173021, г. Великий Новгород, просп. Мира, 44/20</p></bio><bio xml:lang="en"><p>Sergey G. Peshekhonov —Cand. Sci. (Med.), Gastroenterologist</p><p>173021, Veliki Novgorod, Mira ave., 44/20</p></bio><email xlink:type="simple">sgpesh@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9038-3732</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полуэктова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Poluektova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полуэктова Елена Александровна — доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии, врач-гастроэнтеролог отделения хронических заболеваний кишечника и поджелудочной железы Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко</p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Elena A. Poluektova — Dr. Sci. (Med.), Professor of the Department of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Gastroenterologist, Department of Chronic Intestinal and Pancreatic Diseases of the Clinic of Internal Diseases Propedeutics, Gastroenterology and Hepatology named after V.Kh. Vasilenko</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">luektova_e_a@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-5843-7913</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenova</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семенова Татьяна Ивановна — заведующая гастроэнтерологическим отделением</p><p>180016, г. Псков, ул. Коммунальная, 23</p></bio><bio xml:lang="en"><p>Tatyana I. Semenova — Headof theGastroenterologyDepartment, Pskov City Hospital, Chief Freelance Gastroenterologist of the Pskov Region State Committee for Health and Pharmacy</p><p>180016, Pskov, Kommunalnaya str., 23</p></bio><email xlink:type="simple">doksemenova@yandex.ru</email><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2397-4839</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Серикова</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Serikova</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Серикова Светлана Николаевна — доктор медицинских наук, профессор кафедры хирургии № 3</p><p>350063, г. Краснодар, ул. Митрофана Седина, 4</p></bio><bio xml:lang="en"><p>Svetlana N. Serikova — Dr. Sci. (Med.), Professor of the Department of Surgery No 3 of Faculty of Advanced Training and Professional Retraining of Specialists</p><p>350063, Krasnodar, Mitrofana Sedina str., 4</p></bio><email xlink:type="simple">serikovasn@mail.ru</email><xref ref-type="aff" rid="aff-9"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4054-9180</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тарасова Галина Николаевна — доктор медицинских наук, профессор</p><p>344022, г. Ростов-на-Дону, Нахичеванский пер., 29</p></bio><bio xml:lang="en"><p>Galina N. Tarasova — Dr. Sci. (Med.), Professor</p><p>344022, Rostov-on-Don, Nakhichevanskiy lane, 29</p></bio><email xlink:type="simple">doctor-gastro@yandex.ru</email><xref ref-type="aff" rid="aff-10"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2449-6912</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Труш</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Trush</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Труш Елизавета Александровна — аспирант кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии</p><p>119435, г. Москва, ул. Погодинская, 1, стр. 1</p></bio><bio xml:lang="en"><p>Elizaveta A. Trush — Postgraduate at the Department of of Internal Diseases Propedeutics, Gastroenterology and Hepatology</p><p>119435, Moscow, Pogodinskaya str., 1, build. 1</p></bio><email xlink:type="simple">trush_e_a@student.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6434-1267</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Успенский</surname><given-names>Ю. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Uspenskiy</surname><given-names>Y. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Успенский Юрий Павлович — доктор медицинских наук, профессор, главный гастроэнтеролог Санкт-Петербурга, заведующий кафедрой факультетской терапии им. профессора В.А.  Вальдмана</p><p>194100, г. Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Yury P. Uspenskiy — Dr. Sci. (Med.), Professor, Chief Gastroenterologist of Saint-Peterburg, Head of the Department of Intermediate Level Therapy named after Professor V.A. Valdman</p><p>194100, Saint-Peterburg, Litovskaya str., 2</p></bio><email xlink:type="simple">Uspenskiy65@mail.ru</email><xref ref-type="aff" rid="aff-11"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0944-9811</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хлынов</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Khlynov</surname><given-names>I. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хлынов Игорь Борисович — доктор медицинских наук, доцент кафедры факультетской терапии стоматологического факультета</p><p>620028, г. Екатеринбург, ул. Репина, 3</p></bio><bio xml:lang="en"><p>Igor B. Khlynov — Dr. Sci. (Med.), Associate Professor of the Department of Intermediate Level Therapy, Faculty of Dentistry</p><p>620028, Yekaterinburg, Repina str., 3</p></bio><email xlink:type="simple">hlinov.doc@yandex.ru</email><xref ref-type="aff" rid="aff-12"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9980-2294</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цуканов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsukanov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цуканов Владислав Владимирович — доктор медицинских наук, профессор, заведующий клиническим отделением патологии пищеварительной системы у взрослых и детей</p><p>660022, г. Красноярск, ул. Партизана Железняка, 3г.</p></bio><bio xml:lang="en"><p>Vladislav V. Tsukanov — Dr. Sci.(Med.), Professor, Head of the Clinical Department of Pathology of the Digestive System in Adults and Children, Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”</p><p>660022, Krasnoyarsk, Partizana Zheleznyaka str., 3g</p></bio><email xlink:type="simple">gastro@impn.ru</email><xref ref-type="aff" rid="aff-13"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3272-9600</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернусь</surname><given-names>Н. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernus</surname><given-names>N. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернусь Наталья Павловна — кандидат медицинских наук, ассистент кафедры поликлинической терапии; врач-гастроэнтеролог</p><p>121165, г. Москва, ул. Киевская, 24</p></bio><bio xml:lang="en"><p>Natalia P. Chernus — Cand. Sci. (Med.), Teaching Assistant at the Department of Polyclinic Therapy</p><p>121165, Moscow, Kievskaya str., 24</p></bio><email xlink:type="simple">chernusnp@mail.ru</email><xref ref-type="aff" rid="aff-14"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Министерства здравоохранения  Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University named after I.I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «Ярославская областная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>БУЗ ВО «Вологодская городская больница № 1»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФБГОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician I.P. Pavlov First St. Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>ООО «Лечебно-диагностический центр “Здоровье”»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Diagnostic and Treatment Centre “Zdorov'e”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>ГБУЗ ПО «Псковская городская больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кубанский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-10"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-11"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State Paediatric Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-12"><aff xml:lang="ru"><institution>ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ural State Medial University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-13"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр “Красноярский научный центр” СО РАН», Научно-исследовательский институт медицинских проблем Севера</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, Research Institute of Medical Problems of the North</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-14"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»» Министерства здравоохранения Российской Федерации (Сеченовский Университет); ГБУЗ «Консультативно-диагностический центр № 4» департамента здравоохранения г. Москвы, филиал № 3, поликлиника № 2</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University); Consultative and Diagnostic Center No. 4 of the Moscow Health Department, Branch No. 3, Policlinic No. 2</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>01</day><month>12</month><year>2023</year></pub-date><volume>33</volume><issue>5</issue><fpage>41</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивашкин В.Т., Абдулхаков Р.А., Бакулин И.Г., Зайцев С.В., Лучина В.И., Мехтиев С.Н., Пешехонов С.Г., Полуэктова Е.А., Семенова Т.И., Серикова С.Н., Тарасова Г.Н., Труш Е.А., Успенский Ю.П., Хлынов И.Б., Цуканов В.В., Чернусь Н.П., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ивашкин В.Т., Абдулхаков Р.А., Бакулин И.Г., Зайцев С.В., Лучина В.И., Мехтиев С.Н., Пешехонов С.Г., Полуэктова Е.А., Семенова Т.И., Серикова С.Н., Тарасова Г.Н., Труш Е.А., Успенский Ю.П., Хлынов И.Б., Цуканов В.В., Чернусь Н.П.</copyright-holder><copyright-holder xml:lang="en">Ivashkin V.T., Abdulkhakov R.A., Bakulin I.G., Zaitsev S.V., Luchina V.I., Mekhtiyev S.N., Peshekhonov S.G., Poluektova E.A., Semenova T.I., Serikova S.N., Tarasova G.N., Trush E.A., Uspenskiy Y.P., Khlynov I.B., Tsukanov V.V., Chernus N.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gastro-j.ru/jour/article/view/868">https://www.gastro-j.ru/jour/article/view/868</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: изучение эффективности и безопасности применения препарата Колофорт® у амбулаторных пациентов с синдромом раздраженного кишечника (СРК) после перенесенной новой коронавирусной инфекции.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Наблюдательная неинтервенционная программа проводилась у пациентов с обострением симптомов СРК после перенесенной новой коронавирусной инфекции. В исследовании принял участие 141 пациент. В окончательный анализ эффективности были включены данные 127 участников исследования. Все пациенты предъявляли жалобы на усиление/появление гастроинтестинальных симптомов, появившихся в течение 1–6 месяцев после перенесенной инфекции (у всех пациентов в анамнезе была перенесенная инфекция COVID-19). Для оценки наличия и выраженности симптомов заболевания применялся опросник «7 × 7» до начала лечения и через 3 месяца после начала лечения.</p></sec><sec><title>Результаты</title><p>Результаты. На этапе включения в программу средний суммарный балл по опроснику «7 × 7» составил 17,36, что соответствовало умеренно выраженному расстройству. За период лечения средний суммарный балл снизился до 6,14, что соответствовало пограничному расстройству. Кроме того, значимое улучшение наблюдалось по каждому симптому в отдельности. Через 3 месяца терапии врачи оценивали общее впечатление от проводимого лечения по 5-балльной шкале Ликерта от «очень эффективно» до «неэффективно». Средний балл составил 4,24. Кроме того, серьезных нежелательных явлений во время приема препарата выявлено не было.</p></sec><sec><title>Заключение</title><p>Заключение. В условиях реальной клинической практики препарат Колофорт® продемонстрировал высокую клиническую эффективность в лечении пациентов с СРК после перенесенной инфекции COVID-19.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: to study the effectiveness and safety of using the drug Kolofort® in outpatients with irritable bowel syndrome (IBS) after a new coronavirus infection.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. An observational non-interventional program was conducted in patients with exacerbation of IBS symptoms after a new coronavirus infection. One hundred forty-one patients took part in the study. The final efficacy analysis included data from 127 study participants. All patients complained of increased/appearing gastrointestinal symptoms that appeared within 1–6 months after the infection (all patients had a history of COVID-19 infection). To assess the presence and severity of symptoms of the disease, the “7 × 7” questionnaire was used before the start of treatment and three months after the start of treatment.</p></sec><sec><title>Results</title><p>Results. At the stage of inclusion in the program, the average total score on the “7 × 7” questionnaire was 17.36, which corresponded to a moderately severe disorder. During the treatment period, the average total score decreased to 6.14, which corresponded to borderline disorder. In addition, significant improvement was observed for each symptom separately. After three months of therapy, doctors rated the overall impression of the treatment on a 5-point Likert scale from “very effective” to “ineffective”. The average score was 4.24. In addition, no serious adverse events were identified while taking the drug.</p></sec><sec><title>Conclusion</title><p>Conclusion. In real clinical practice, the drug Kolofort® demonstrated high clinical efficacy in the treatment of patients with IBS after COVID-19 infection.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром раздраженного кишечника</kwd><kwd>постковидный синдром</kwd><kwd>функциональные заболевания желудочно-кишечного тракта</kwd></kwd-group><kwd-group xml:lang="en"><kwd>irritable bowel syndrome</kwd><kwd>post-Covid syndrome</kwd><kwd>functional diseases of the gastrointestinal tract</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">на проведение наблюдательной программы был получен грант от компании ООО «НПФ  “Материа Медика Холдинг”»</funding-statement><funding-statement xml:lang="en">a grant was received from the company “NPF Materia Medica Holding” to conduct the observational program</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Marasco G, Cremon C, Barbaro MR, Salvi D, Cacciari G, Kagramanova A, et al. 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