gastro-jРоссийский журнал гастроэнтерологии, гепатологии, колопроктологииRussian Journal of Gastroenterology, Hepatology, Coloproctology1382-43762658-6673«Gastro» LLC10.22416/1382-4376-2024-34-3-62-77gastro-j-959Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL ARTICLESОднонуклеотидные полиморфизмы, ассоциированные с повышенным риском развития синдрома раздраженного кишечника с преобладанием запора: метаанализSingle Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysishttps://orcid.org/0000-0003-2449-6912ТрушЕ. А.TrushE. A.

Труш Елизавета Александровна — аспирант кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии

119435, г. Москва, ул. Погодинская, 1, стр. 1

Elizaveta A. Trush — Postgraduate, Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1

dr.gon-fly@mail.ruhttps://orcid.org/0000-0001-6647-0572КарчевскаяА. Е.KarchevskayaA. E.

Карчевская Анна Евгеньевна — студентка Института клинической медицины им. Н.В. Склифосовского

119435, г. Москва, ул. Россолимо, 11, стр. 2

Anna E. Karchevskaya — Student, N.V. Sklifosovskiy Institute of Clinical Medicine

119435, Moscow, Rossolimo str., 11, build. 2

karchevskaya_a_e@student.sechenov.ruhttps://orcid.org/0000-0001-7513-1636МасленниковР. В.MaslennikovR. V.

Масленников Роман Вячеславович — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии

119435, г. Москва, ул. Погодинская, 1, стр. 1

Roman V. Maslennikov — Cand. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1

maslennikov_r_v@staff.sechenov.ruhttps://orcid.org/0000-0002-9038-3732ПолуэктоваЕ. А.PoluektovaE. A.

Полуэктова Елена Александровна — доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии; врач-гастроэнтеролог отделения хронических заболеваний кишечника и поджелудочной железы Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко

119435, г. Москва, ул. Погодинская, 1, стр. 1

Elena A. Poluektova — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology, Gastroenterologist of the Department of Chronic Intestinal and Pancreatic Diseases, V.Kh. Vasilenko Clinic of Internal Diseases Propedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1

poluektova_e_a@staff.sechenov.ruhttps://orcid.org/0000-0001-8148-2862ШифринО. С.ShifrinO. S.

Шифрин Олег Самуилович — доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии; заведующий отделением хронических заболеваний кишечника и поджелудочной железы Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко

119435, г. Москва, ул. Погодинская, 1, стр. 1

Oleg S. Shifrin — Dr. Sci. (Med.), Professor f the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology, Head of the Department of Chronic Intestinal and Pancreatic Diseases of V.Kh. Vasilenko Clinic of Internal Diseases Propedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1

shifrin_o_s@staff.sechenov.ruhttps://orcid.org/0000-0002-6815-6015ИвашкинВ. Т.IvashkinV. T.

Ивашкин Владимир Трофимович — доктор медицинских наук, профессор, академик РАН, заведующий кафедрой пропедевтики внутренних болезней, гастроэнтерологии и гепатологии; директор Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В.Х. Василенко

119435, г. Москва, ул. Погодинская, 1, стр. 1

Vladimir T. Ivashkin — Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology, Director of V.Kh. Vasilenko Clinic of Internal Diseases Propedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1

ivashkin_v_t@staff.sechenov.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation2024120820243436277Copyright © Труш Е.А., Карчевская А.Е., Масленников Р.В., Полуэктова Е.А., Шифрин О.С., Ивашкин В.Т., 20242024Труш Е.А., Карчевская А.Е., Масленников Р.В., Полуэктова Е.А., Шифрин О.С., Ивашкин В.Т.Trush E.A., Karchevskaya A.E., Maslennikov R.V., Poluektova E.A., Shifrin O.S., Ivashkin V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gastro-j.ru/jour/article/view/959Введение

Введение. Сочетание генетической предрасположенности с факторами окружающей среды и психоэмоциональным состоянием пациента играет ключевую роль в развитии синдрома раздраженного кишечника (СРК). Изучение ассоциации полиморфизмов генов с СРК может помочь в понимании доминирующих патофизиологических механизмов. На сегодня по данной теме опубликовано 11 метаанализов, однако среди них нет ни одного, который исчерпывающе обобщил бы данные о распространенности генетических полиморфизмов среди пациентов с СРК с преобладанием запора (СРК-З).

Цель

Цель: обобщение опубликованных данных о влиянии полиморфизмов генов на риск развития СРК-З.

Материалы и методы

Материалы и методы. Поиск литературы проводился в электронных базах PubMed и Scopus. На основе найденных исследований проводился метаанализ в соответствии с международными рекомендациями «Предпочитаемые элементы отчетности для систематических обзоров и метаанализов» (Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA). В анализ включались работы, в которых изучалась ассоциация генетических полиморфизмов у пациентов, страдающих СРК-З.

Результаты

Результаты. Критериям включения соответствовали 34 исследования. Полученных данных оказалось достаточно для проведения метаанализа по полиморфизмам трех из перечисленных генов: SLC6A4 (10 статей), GNB3 (5 статей), ADRA2A (4 статьи). Не было выявлено статистически значимой ассоциации полиморфизма 5-HTTLPR гена SLC6A4 и полиморфизма C825T (rs5443) гена GNB3 как с СРК, так и с СРК-З. Была выявлена статистически значимая ассоциация полиморфизма 1291C>G гена ADRA2A как с СРК, так и с СРК-З.

Выводы

Выводы. По данным проведенного нами метаанализа выявлена статистически значимая ассоциация полиморфизма 1291C>G гена ADRA2A как с СРК, так и с СРК-З в смешанной популяции. Ни гомозиготный, ни гетерозиготный варианты полиморфизма 5-HTTLPR гена SLC6A4, а также полиморфизма C825T гена GNB3 не были ассоциированы ни с СРК-З, ни с СРК в целом.

Introduction

Introduction. Genetic predisposition in combination with environmental factors and the patient’s psychological and emotional state play a key role in the development of irritable bowel syndrome (IBS). Studies of association between genetic polymorphisms and IBS can help in understanding the key pathophysiological mechanisms. To date, 11 meta-analyses on this issue have been published, however, none of them comprehensively summarize the data on the prevalence of genetic polymorphisms in IBS with predominant constipation (IBS-C).

Aim

Aim: to summarize the published data on the impact of genetic polymorphisms on the risk of IBS-C.

Materials and methods

Materials and methods. A literature search was performed in the PubMed and Scopus databases. Identified studies were used for a meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Publications investigating genetic polymorphisms in patients with IBS-C were included in this analysis.

Results

Results. A total of 34 studies met the inclusion criteria. The collected data were sufficient to conduct a meta-analysis on polymorphisms of three of the listed genes: SLC6A4 (10 articles), GNB3 (5 articles), ADRA2A (4 articles). No significant association was found between the SLC6A4 (5-HTTLPR) polymorphism, GNB3 c.825C > T (rs5443) polymorphism and either IBS or IBS-C. It was found that ADRA2A 1291C>G polymorphism was significantly associated with both IBS and IBS-C.

Conclusions

Conclusions. Our meta-analysis revealed that ADRA2A 1291C>G polymorphism was significantly associated with both IBS and IBS-C in the mixed population. Neither homozygous nor heterozygous variants of the SLC6A4 (5-HTTLPR) polymorphism and GNB3 C825T polymorphism were associated with either IBS-C or IBS as a whole.

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The authors declare that there are no conflicts of interest present.