The perspectives of autologous hepatocytes generation for the treatment of liver failure
Abstract
The aim of the review. To analyze the main cellbased sources of hepatocyte for artificial liver generation, to describe the key features of each approach, to discuss benefits and shortcomings.
Summary. Artificial liver transplantation could be an alternative for traditional transplantation. For the artificial liver generation specialized cells are required. So far several sources of hepatocyte-like cells generation are known. This review presents alternative approaches for liver failure treatment: inhibition of epithelial-mesenchymal transformation, e.g. by induction of proliferation (gene therapy with HGF), and by influence on immune imbalance (T-regulatory lymphocytes application).
Conclusion. Evaluation of the main sources of autologous hepatocytes would provide insights into priority directions of future studies, and lead to progress in liver failure treatment.
About the Authors
M. N. Evseeva
Lomonosov Moscow State University
Russian Federation
Russian Federation
Evseeva Mariia N. — post-graduate, Biochemistry and Molecular Medicine Department, Faculty of Fundamental Medicine
119192, Moscow, Lomonosovsky av., 27, bld.1.
A. F. Sheptulina
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Sheptulina Anna F. – post-graduate, Chair of internal diseases propedeutics, medical faculty
119991, Moscow, Pogodinskaya street, 1, bld 1.
Yu. P. Rubtsov
Lomonosov Moscow State University
Russian Federation
Russian Federation
Rubtsov Yury P. – assistant professor, senior scientist, Biochemistry and Molecular Medicine Deptment, Faculty of Medicine
119192, Moscow, Lomonosovsky av. 27, bld. 1.
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Review
For citations:
Evseeva M.N., Sheptulina A.F., Rubtsov Yu.P. The perspectives of autologous hepatocytes generation for the treatment of liver failure. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015;25(6):49-57. (In Russ.)
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