The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease
Abstract
The aim of review. To demonstrate that esophageal and stomach motility disorders play one of basic roles in pathogenesis of gastroesophageal reflux disease (GERD).
Key points. Gastroesophageal reflux disease is related to the group of acid-related diseases, however esophageal and stomach motility disorders play important role in its development. In patients with GERD disorders of primary and secondary peristalsis of the esophagus, increase of frequency of transient lower esophageal sphincter relaxations and pathologic bile refluxes are common.
Conclusion. Numerous studies are devoted to investigation of gastroesophageal reflux disease. The role of motility disorders of the esophagus and the stomach in its pathogenesis, and origin of symptoms of reflux disease and other gastro-intestinal functional diseases, in particular the functional dyspepsia is actively discussed. At upper gastro-intestinal motility disorders application of prokinetics is effective, e.g. itopride hydrochloride, that reduces frequency of transient lower esophageal sphincter relaxations due to decrease of intragastric pressure, activates propulsive stomach motility and eliminates duodenogastric and duodenogastroesophageal refluxes.
About the Authors
Yu. V. Yevsyutina
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Yevsyutina Yuliya V. — post-graduate student, Chair of internal diseases propedeutics, medical faculty
119991, Moscow, Pogodinskaya street, 1, bld 1
A. S. Trukhmanov
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Trukhmanov Alexander S. — MD, PhD, professor, of chair of propedeutics of internal diseases, head of laboratory of functional diagnostics of gastrointestinal diseases, chair of internal diseases propedeutics, medical faculty
119991, Moscow, Pogodinskaya street, 1, bld 1.
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Review
For citations:
Yevsyutina Yu.V., Trukhmanov A.S. The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015;25(5):10-15. (In Russ.)
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